Function Of Defense Responses And Developmental Programs

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Introduction Chorismate mutase (CM) is a central enzyme involved in the shikimate pathway. The shikimate pathway is an aromatic biosynthetic pathway that is responsible for converting primary metabolites phosphoenolpyruvate and erythrose-4-phosphate into chorismate.! This pathway also converts chorismate to prephenate to produce tyrosine and phenylalanine, as well as tryptophan by the conversion of chorismate to anthranilate by anthranilate synthase. These key aromatic amino acids are produced in bacteria, plants, fungi and other apicomplexan parasites. Chorismate mutase is essential for regulating the balance of these key aromatic amino acids, which are then important for the controlling of defense responses and developmental programs within the cel1.2 The rearrangement of chorismate to prephenate is catalyzed by chorismate mutase, which can be formally known as Claisen rearrangement. It provi~rate acceleration to the Claisen rearrangement and this reaction is the only recognized enzymatically catalyzed pericyclic reaction found in primary metabolism. This has prompted a lot of study and interest in the bioorganic circles.3 Chorismate mutase rearranges the chorismate to prephenate by means of an endo-oxabicyclic transition state.4 It exists in an R state and a T state, which is active and inactive respectively, in which there is a sequence homology between these states. The binding of a chorismate mutase to the endo-oxabicyclic transition state analogue inhibitor keeps the
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