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GH And IGF-I: Role In Growth And Metabolism Throughout Life

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Both GH and IGF-I play important roles in growth and metabolism throughout life. GH is essential for postnatal growth in all species, but does also exert important peripheral effects on energy metabolism, body composition, bone metabolism, immune system, muscle function as well as on the central nervous system (CNS), affecting e.g. appetite, cognition and sleep. IGF-I is a mitogen and stimulator of cell proliferation, and has important functions in tissue repair and regenerative processes. It also mediates some of the anabolic and growth activities of GH. Much information on how and where these hormones are produced in the body and the regulation of their expression, as well as how and where GH and IGF-I exert their biological action has been
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