How Can a Disease Progress to Become Systemic?

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A systemic disease is a disease that affects multiple organs, organ system, tissues or the body as a whole. In some cases, local diseases can be sever and metastasize to other organs or tissues, or organ system and become systemic disease such as chronic pancreatitis, rheumatic fever, and cirrhosis. Chronic pancreatitis is inflammation of the pancreas, which doesn’t heal and cause complications such as pseudocyst, infection, breathing problems, diabetes, kidney failure, and malnutrition. Rheumatic fever is also inflammation disease but result from a complication of untreated strep throat which can metastasize and affect the heart’s valves, the heart’s muscle, causes atrial fibrillation, and heart failure. Cirrhosis on the other hand is a final result of liver disease turning liver into scar tissue that can affect the proper functioning of the liver that leads to complications such as portal hypertension, swelling in the legs and abdomen, infections, bleeding, malnutrition, high levels of toxins in the blood, jaundice, and increased risk of liver cancer.(VA, 2007)
In the early stage of any liver disease, it may become inflamed, tender and enlarged. If the inflammation continues over time, it can cause permanent damage. If left untreated, the liver normal tissue starts to change into scar tissue which is called fibrosis. Besides, the scar tissue cannot do the job as the healthy tissue does; it is naturally destructive to the normal functioning of the healthy tissue. It can

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