How Can a Disease Progress to Become Systemic?

The inflammation of the liver is detected by the blood tests taken and can be reduced by drinking lots and lots of fluids, to flush out the toxins. A patient can detect liver inflammation by nausea, vomiting, reduced appetite and jaundice. It is also possible to obtain rash-like symptoms, similar to those of measles or scarlet fever. They can appear all over the body and are very itchy, much like hives. A cortisone cream applied in small amounts to the small bumps can reduce the itch and swelling. Severe scratching of the bumps can leave scars.

If the liver is damaged significantly and a liver transplant is denied or a liver is unavailable the death is prominent. Liver disease can be slowed if the person suffering adapts to change and reaches out to local support groups and organizations for additional information and support.

Cirrhosis is a serious disease of the liver where scar tissue replaces normal healthy tissue, and affects the function and structure of the liver. Liver, which is the largest organ in the body, has a vital roles which are important to keep the body functioning well. Liver makes proteins and enzymes that regulate blood clotting. It also regulates cholesterol and stores the energy. In addition, the liver removes poisons from the blood. 30% of cirrhosis's victims are diagnosed will remain alive for 5 years. Cirrhosis can be defined regarding its causes, symptoms, diagnosis, and treatment.

* Edema: abnormal accumulation of fluid (aka swelling). This is important for cirrhosis because when the tissue starts turning into scar tissue, the kidneys retain more salt. This increase in salt and water causes the visualized swelling. As time progresses, this swelling can affect abdomen area of the body, making edema secondary to hepatocellular failure since it is the tissue cell morphing that causes edema to manifest.

Liver disease resulting from alcohol affects more than two million Americans and is one of the primary causes of illness and death. The liver frees the body of harmful substances, such as alcohol. While the liver breaks down alcohol, it produces toxins that can be even more dangerous than the alcohol consumed (“Beyond Hangovers: Understanding Alcohol's Impact Your Health” 13). “These by-products damage liver cells, promote inflammation, and weaken the body’s natural defenses. Eventually, these problems can disrupt the body’s metabolism and impair the function of other organs” (“Beyond Hangovers: Understanding Alcohol's Impact Your Health” 13). A condition called steatosis is the result of fat build up in the liver and is the

Systemic and can quickly become life-threatening with organ failure, including reduced blood pressure and heart failure 1 2

Cirrhosis is the eighth leading cause of death in the United States and the thirteenth leading cause of death worldwide.1 Cirrhosis is the irreversible fibrosis of the liver characterized by hepatic architectural distortion secondary to fibrous tissue and the formation of regenerative nodules.2 These anatomical changes cause hepatic vascular resistance and an increase in blood flow leading to portal hypertension. Porto-systemic collaterals develop in order to overcome the increased portal pressure gradient.3 Nitric oxide, an endogenous vasodilator is also released in effort to overcome portal pressure with the expense of causing systemic vasodilation and a decrease in blood pressure. As a result, a marked activation of neurohumoral vasoactive factors occurs in an effort to maintain an effective arterial blood pressure. Hypervolemia, increased cardiac index, decreased systemic vascular resistance, and systemic hypotension are manifestations of portal hypertension.3 Chronic hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholism, nonalcoholic steatohepatitis (NASH), and non-alcoholic fatty liver disease (NAFLD) are all major causes of cirrhosis.

In agreement is ………………….which state that “the speed at which inflammation and scarring take place varies between people. Some develop severe liver scarring (cirrhosis) within 20 years. In others, liver disease progresses slowly and does not become a major problem during their lifetime.”

According to the American Liver Foundation, a healthy liver cleans blood, fights infection processes food and stores energy. The liver is able to regenerate itself, but when it becomes too damaged or is prevented from regenerating, it will fail and no longer be able to keep able to keep one alive (2015). Despite its ability to regenerate, chronic liver disease and cirrhosis is the twelfth leading cause of death of death in the United States. My interest in further exploring liver related deaths is the due to the impact that liver disease has had on my family. My young cousin was born with a malignant tumor on her liver and spent the first several years of her life undergoing surgeries and chemotherapy. She survived the treatment and at the age of 4 was free of cancer. At the age of 24 she was told that her liver was beginning the process of failure and she would need to be put on the transplant liver for long-term survival. My grandmother died of cirrhosis of the liver and my father, after 3 years of treatment for melanoma, was diagnosed with liver failure. He had a procedure to prolong the useful life of his liver, but the damage to his liver will not allow his liver to regenerate and it will likely be liver failure which leads to his death.

17. Cirrhosis is a consequence of chronic liver disease where the tissue becomes fibrotic. How could this disease impact the blood

Cirrhosis is a consequence of chronic liver disease characterized by replacement of normal, healthy liver tissue by fibrotic scar tissue, blocking the flow of blood through the organ and preventing it from working as it should, as well as regenerative nodules leading to progressive loss of liver function. The liver, the largest organ in the body, is vital in keeping the body functioning properly. It removes or neutralizes poisons from the blood, produces immune agents to control infection, and removes germs and bacteria from the blood. It

Additionally, many chronic liver diseases can lead to cirrhosis. For example, nonalcoholic fatty liver disease (NAFLD) can lead to cirrhosis and is associated with obesity, hyperlipidemia, metabolic syndrome and type 2 diabetes mellitus. Hereditary metabolic disorders such as hemochromatosis and Wilson disease can also lead to cirrhosis (McCance & Heuther, 2014). It seems the cause of cirrhosis is multifaceted. Additionally, many diseases can lead to cirrhosis and it is understandable why the etiology of cirrhosis has not been parsed out, especially because the cause can differ from a

There are up to more than a billion diseases in the world, and we still have plenty more to discover, and one disease that can be deadly is Chronic Liver Disease. Chronic Liver Disease is a disease that destroys liver cells, and replaces them with “Scare Tissue”, which is a tissue that connects to the organ and creates a scar. In addition, Chronic Liver Disease has multiple stages, the final stage of Chronic Liver Disease is “Cirrhosis” moreover, cirrhosis damages and destroys

Even though the liver has the ability to react to damage and can repair itself, repetitive insults can produce liver failure or deadly diseases, infections, and disorders. A few such diseases are viral hepatitis, yellow fever, and rubella. Some of the disease caused by bacteria are amebic dysentery, leptospirosis, and streptococcal infections. These diseases can fatally damage the liver.

"Many alcoholics exhibit swollen and tender livers. The prolonged use of large amounts of alcoholism without adequate diet may cause serious liver damage, such as