Causative Organism(s): Human papillomavirus known as HPV is a Papovavirus that is transmitted sexually. It is in fact one of the most common sexually transmitted disease in the United States, it comes in hundred different forms and affects the body in different ways. Some forms of it can cause warts while others may cause cervical changes that may lead to cancer (4). HPV can infect both man and woman but only causes cancer in females. Although HPV seems to have a more severe effect on women than men it still places both in danger. Men can unknowingly be carriers of the virus that can affect the woman severely, therefore both men and women have to take responsibility to decrease the spread of HPV (5). HPV is a small unenveloped virus with …show more content…
The E6 and E7 proteins play and important rule in oncogenic property of human papillomavirus that can cause anogenital cancers as their high risk factor and warts as their low risk factor. E6 AND E7 proteins promote cell growth by inactivating the tumor suppressor proteins P53 and PRb (5).
Pathogenesis: Most people who are infected with genital HPV do not develop signs and symptoms from it. HPV is asymptomatic and in most cases the body 's immune system resolve the HPV spontaneously within two years (4). There are several tests that can be done to diagnose the HPV infection, Pap test a sample of cervical cells or vaginal cells are collected and sent to the lab. This test can tell you whether the cell structures have changed and if an abnormal looking cell is present it usually means there is a high risk of developing cancer. The DNA test detects whether high risk HPV are present. The vinegar solution test, a vinegar solution is applied to the genital area, if HPV infection is present the areas will turn white. Unfortunately there are no tests available for men (7). HPV is categorized as "Low risk" and "High risk". The Low risk strands have very few or no symptoms. The most common symptoms are genital warts. Genital warts usually pink or flesh cauliflower type tumor on the genital area. The high risk strands have also few are no visible symptoms due to
What is the Human Papillomavirus? Commonly known as HPV, it is an infection that spreads through sexual contact. There are over one hundred different types of HPV; several types cause genital warts, while other high risk strands can lead to cancer of the cervix, anus, vagina, and penis. Because HPV is often asymptomatic, many people are unaware of their infection status, and thus, their potential for transmitting the virus to a sexual partner. The significance of the Human Papillomavirus is that fifty percent of Americans who are sexually active will contract it within their lives, and at any given point there are twenty million Americans already infected with it (“By the numbers: HPV Vaccine”).
HPV is the number one sexually transmitted infection (STI) in the United States, and anyone who is sexually active is at risk of contracting the virus. HPV is transmitted through intimate skin-to-skin contact with someone who has the virus, and it is so common that most all sexually active men and women encounter a strain without ever knowing they’re infected (CDC). There are many strains of the HPV virus, some of which don’t cause cervical cancer. To help understand and classify the types of HPV, the terms low-risk and high-risk HPV are used. Some
The human papillomavirus remains one of the highest common sexually transmitted infections in the United States. The human papillomavirus dates back to the nineteen hundreds. Scientists during the nineteen hundreds did not comprehend on why people who had sexually transmitted infections also had cancer. It was not until the nineteen-eighties, that a scientist discovered that the human papilloma virus caused cancer (Preventing Cervical Cancer). Moreover the human papillomavirus causes genital warts in both men and women. In the year two thousand and six, a scientist generated two vaccines that protect the human body from contracting the virus. The Food and Drug Administration approved Gardasil and Cervarix since they are clinically tested
Human papilloma virus will cause almost all cases of cervical cancer, and therefore is the highest risk factor. There are many factors that will determine if HPV will lead to cervical cancer, HPV directly affects and transforms either or both the deepest layer of the mucous epithelial cells and more superficial layers. Targeting the receptors found in the layers of the stratified squamous epithelium. This is where the virus will proliferate into more differentiated cells to spawn offspring virus. The virus replication is what causes the skin characteristics of a wart. With the help of a pap smear, we are able to investigate if cervical epithelial cells are healthy and normal or determine which point in dysplasia they are at in transforming to cancerous cells. The HPV virus does not need a host to survive, and can survive in low and high temperatures.
HPV is the most widely recognized sexually transmitted disease, and there are more than 40 sorts of HPV that can contaminate the genital regions of guys and females. This STI is passed through genital contact, and can be transmitted even when the infected person has no signs or symptoms. Most infected individuals do not realize they are infected because signs and symptoms are not always obvious. HPV can cause serious health problems such as genital warts and cervical cancer. About 360,000 persons in the U.S. get genital warts each year, and more than 11,000 women in the U.S. get cervical cancer each year. According to this website “Approximately 79 million Americans are currently infected with HPV. About 14 million people become
Human papillomaviruses (HPVs) are a group of more than 200 related viruses. More than 40 HPV types can be easily spread through direct sexual contact, from the skin and mucous membranes of infected people to the skin and mucous membranes of their partners. They can be spread by vaginal, anal, and oral sex. Other HPV types are responsible for non-genital warts, which are not sexually transmitted. High-risk HPV types cause approximately 5 percent of all cancers worldwide. In the United States, high-risk HPV types cause approximately 3 percent of all cancer cases among women and 2 percent of all cancer cases among men. High-risk HPVs cause several types of cancer: cervical cancer, vaginal cancer, vulvar cancer, anal cancer, penile
Human papilloma virus (HPV) is a name derived from group of viruses that affect the human skin and other moist areas found in the human body, such as the cervix, anus, mouth and throat. There are more than 100 species of HPV, of which only thirty of them affect the genital area. Genital HPV is very contagious and are spread during sexual intercourse and skin to skin of the genital areas. Some HPV can be physically detected, when there are visible genital warts seen around the site. HPV that do not exhibit clinical symptoms are known as sub-clinical HPV, which connotes that they are not visible, neither do they have recognizable symptoms (Women 's health specialist, November, 2009). Most of the time, Sub - clinical HPV is discovered when there is an abnormal results from pap smear. On the other hand, research also shows that men do encounter sub-clinical HPV, but the test does not work for them. Therefore, men may have it without knowing.
Often times these HPV infection goes away over the course of one or two years due to elimination of the infected cells by the body’s immune system, making it hard to know when or from whom a person got the virus. However, sometimes these infected cells are not destroyed, and a persistent infection results and grows, developing mutations in genes, leading to the formation of warts and cancers (“HPV and Cancer”). The term “papilloma” actually refers to warts that results from some HPV types (“Information About the Human Papillomavirus”). HPV is the most common cause of genital and common warts (“HPV Infection”). Genital warts appear as small, flat, cauliflower-like bumps mostly on the vulva for women and penis and scrotum or around the anus for men. (Ibid.) These genital warts rarely cause discomfort or pain, though they may itch (Ibid.). Common warts usually occurs on hands, fingers or elbows with rough, raised bumps (Ibid.). The majority of common warts are unsightly, but they can be also painful and lead to injury or bleeding (Ibid.). Often, warts are confused with other skin problem that are not sexually transmitted and since they are contagious, it is easy to spread it by contact with a wart or with something that touched the wart (Ibid.). Small number of infection with high-risk HPV can cause cancers such as cervical, oropharyngeal, anal or other rarer cancers, and amongst these types of cancers, cervical cancer is the most frequently appeared cancer (Ibid.). HPV is a well-established cause of cervical cancer. About 12,000 women in the US get cervical cancer each year and nearly all of those cases are associated with HPV (Ibid.). Many people have misunderstanding of the relationship between warts and cancer, however, warts are not cancerous and cancers are caused by different HPV
Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections in the United States. HPV belong to a family of viruses that cause cell changes in the epithelia resulting in benign skin lesions called warts and verrucae. Type 6 and 11 cause warts and are included under the low risk HPVs,Types 16,18,31,33,45 cause cervical cancer and are included under high risk HPVs(CDC,2014). The virus affects the skin and mucous membrane especially of the reproductive organs. Cervical Cancer and other Ano-genital cancers are seen in women with persistent genital HPV infection. HPV that affects the skin can be transmitted by skin to skin contact with an affected person and Genital HPV is spread through Kissing and Oral
HPV is not spread via bodily fluids; it is a skin to skin contact virus. It’s caused by having oral, vaginal, or anal sex with an infected person. The throat, genitalia, and mouth in both men and women can be infected. HPV can also be transmitted during child birth causing genital and respiratory system infections. Currently, there is no cure for the HPV virus. Women can be tested for HPV at the time of their pap smear. For men, there is no test available at this time to test for the infection. In most cases, HPV goes away on its own without causing any problems. However, it can remain dormant and later infect a new or existing partner. People with weak immune systems may be less able to fight off HPV and more likely to develop
A good history and clinical examination is sufficient for diagnosis. For women, swabs are taken from the cervix as part of a pap smear. A Pap smear detects any abnormal cells in the cervix, which may be a sign of precancerous change. A pap sample can also be used check the DNA of the virus, to detect its subtype. Women whose Pap tests are abnormal are asked to get Pap smears repeated over time, in order to detect the cancer at an early age. Pap smears are combined with HPV DNA Test for women aged over 30. In men, no specific test is needed - physical examination is sufficient for diagnosis.
There are several strains of the human papillomavirus the highest risk strains for cervical cancer are HPV 16 and 18 those strains cause 70 percent of cervical cancer along with a few other high-risk strains. There are low-risk strains that cause things such as common warts, which are seen on the skin, or genital warts seen on the mucous membranes. For the purpose of this paper, we will only be covering strains that can lead to cervical cancer. Transmission of HPV is fairly easy which may be why it is so prominent in our society today. HPV is transmitted primarily by sexual activity but can also occur due to prolonged exposure to things like skin-to-skin interaction, or wear of clothing that has been chronically exposed to the virus. It is
The human papilloma virus (HPV) is the most common sexually transmitted disease, with a worldwide point prevalence of 11.7%., in the United States over 79 million people are already infected with HPV, and over 14 million new HPV infections occur each year CITE 1,2,5. HPV affecting both men and women, has an estimated lifetime prevalence of 80-90%, it is likely that most sexually active people will become infected with HPV before the age of 45 CITE 1, 3. Although over 100 HPV genotypes have been identified, only 40 infect the genital area. These 40 are further subdivided into high risk oncogenic genotypes, and low risk the genotypes responsible for genital warts and recurrent papillomatosis CITE 8,3. HPV is associated with virtually all cervical cancers, and over 90% of anal cancers CITE 1. The cost of preventing and treating HPV and its associated diseases is estimated at eight billion dollars annually
Symptoms. In most cases, the immune system can defeat the virus before anything happens. When it is not stopped, a person will notice warts appearing. The appearance of the wart depends on the variation of infection (HPV, 2014). There are genital warts, common warts, flat warts and planter warts. Each varies in shape, size and texture. Most of these are likely to
The family of Human Papilloma Virus contains a massive number of genitivally related Viruses. Many can cause warts, including warts that are commonly found on the skin.