Within a Single Institution
Although there are many methods that help with diagnosing prostate cancer such as biomarkers and needle core biopsy, it is the practice patterns of different pathologists that in the end determine the diagnosis. This article explains how and why interobserver variability can affect the ability to diagnose prostate cancer. Additionally, it determines the outliers for immunohistochemistry work up. Immunohistochemistry is a method that can help aid the diagnosis of prostate needle core biopsy specimens. This procedure looks at the small foci of prostatic adenocarcinomas and limits the over diagnosis of non-neoplastic look-alikes.
This study analyzed immunohistochemistry usage and data as well as practice patterns from many pathologists at a tertiary care center to identify the outlying practice patterns. Prior
…show more content…
The cases were placed into four categories: non-neoplastic, high grade intraepithelial neoplasia, atypical small acinar proliferation, or adenocarcinoma. The findings showed that there were either lower rates of non-neoplastic diagnoses with higher rate of high grade intraepithelial neoplasia, or vice versa. The diagnosis of adenocarcinoma and atypical small acinar proliferation had no significant variability between pathologists. The study suggests that institutions should analyze pathologists practice patterns to determine if the pathologist is an outlier with errors in his/her diagnosis. This would affect clinical management. Along with determining the pathologists’ diagnoses, immunohistochemistry use was also observed. The rate of immunohistochemistry usage was lower than other tertiary care centers. Also, immunohistochemistry was used greatly to determine adenocarcinomas. The articles reports “efficient use of IHC’s in diagnosing prostate biopsy specimens could have important cost-saving
Papanicolaou test fails to detect, on average, 50% of clinically significant pre-cancers and cancers that are present at the time of testing. The interpretation of Papanicolaou smears is subjective, and cellular abnormalities may be missed because of the reader's fatigue and distraction. Another drawback of the Papanicolaou test is the need for highly skilled cytotechnologists, the training of whom takes several years (Louvanto, Chevarie-Davis, Ramanakumar, Franco, & Ferenczy, 2014).
After all the different types of testing if there is any abnormality then a biopsy would be the next step. A prostate biopsy is a procedure in which the doctor uses the Trans rectal ultrasound (TRUS) to view and guide a needle into the prostate to take small samples of tissue. These tissues are then examined under a microscope for the presence of cancer. The biopsy procedure is short and you can usually go home the same day. There may be some
This is a population based retrospective study. It examined the incidence of hospitalization among men who underwent TRUS guided prostates biopsy between January 1, 1996 and December 31, 2005 in Ontario Canada. No independent or dependent variables were identified. TRUS guided biopsies were carried out by relatively small number (437) of specialist physicians (urologists) (Nam et al., 2012). The researchers used Ontario Health Insurance Plan codes, Canadian
Prostate cancer is a kind of cancer that affects the prostate gland in men. It is a common cancer that grows slowly and its treatment can be done successfully if it is detected at an early stage. Sometimes, symptoms are not visible in case of cancer limited to the prostate gland which may result into metastatic cancer. To detect the symptoms, active surveillance can be done. There are various options available
Another method to detect this cancer is with a Prostate Specific Antigen (PSA). Protein in the blood that is produced only by prostate cells is reflected the volume of both benign and malignant prostate tissue in the PSA. The higher the PSA level is the more likely it is that Prostate Cancer present. (“Prostate
Tumour markers are detectable cancer cells that are found in the spinal fluid, urine or blood (Craft, Gordon & Tiziani, 2011). They can include enzymes, hormones, antigens or genes (Craft, Gordon & Tiziani, 2011).Tumour markers are beneficial, in that they are able to identify high risk cancers in individuals (Craft, Gordon & Tiziani, 2011). They also help by diagnosing different cancer types (Craft, Gordon & Tiziani, 2011).There are different markers that are able to identify different cancer types (Craft, Gordon & Tiziani, 2011). For example, Prostrate-specific antigen (PSA) identifies prostate cancer cells and a-fetoprotein (AFP) identifies Hepatic cancer cells (Craft, Gordon & Tiziani, 2011). There is a disadvantage of using tumour markers, and that is that some non-cancerous tissues produce markers (Craft, Gordon & Tiziani, 2011). Therefore, to determine whether a patient has cancer, additional tests are necessary (Craft, Gordon & Tiziani, 2011).
The paper Prostate Cancer Screening is written as an analysis of the controversy on the use of screening for prostate cancer. The paper itself is written between doctors Elie Mulhem, Nikolaus Fulbright, and Norah Duncan. The analysis, while likely directed to those in the medical field, is tailored to be easily understood by laypeople. While the paper itself is a somewhat brief, surface level analysis of the situation, it does support the notion that prostate cancer screening through methods like prostate-specific antigen (PSA) testing and digital-rectal examinations (DRE) have questionable effectiveness. The intention of the paper appears to persuade doctors and the public to the viewpoint that prostate
Today, prostate cancer is usually detected through screening, and there are two methods for early detection. The prostate-specific antigen test (PSA) is used, but there are
Physicians can perform tests on DNA, RNA and cell proteins to determine if cancer is present within the body. After an individual discovers a sign that leads them to believe that cancerous cells are present within their body, an assessment of a biopsy is the most accurate and common procedure to determine the presence and type of cancer. A biopsy is a process in which a small sample of body tissue is removed and examined by an expert. These processes of detection lead to the declaration of cancer type and viable treatment plans.
In the case for PSA screening, PCa is the leading internal malignancy in US men and the second leading cause of cancer death in American men. Early detection of prostate cancers offers the best chance of cure. The PSA blood test is the best chance of cure. Currently, the PSA blood test is the best currently available way to detect PCa and it is easy, safe and inexpensive. PSA test results is a piece of information, it is what doctors do with the information that becomes the issue. However, the great majority of PSA detected tumors have the histologic characteristics of clinically important cancers. Also, PSA detection has found tumors early advancing the diagnosis by Seeral years (5-13) and prostate cancer mortality rates in U.S have decreased by 4% (patho book) since 1992, which is 5 years after initiation of prostate screenings. The dilemma is over treating the clinically unimportant disease versus under
Each year approximately 233,000 men will be diagnosed with prostate cancer (Eggener, Cifu, & Nabhan, 2015). In 2015, prostate cancer was the second most common cancer related cause of death among United States men (Eggener, et. al., 2015). While the majority of prostate cancers are slow growing with a 5-year survival rate of approximately 98%, statistics show that when prostate cancer is identified as metastatic, the 5-year survival rate dramatically drops down to 20-25% (Eggener, et. al., 2015). According to these numbers alone, it appears screening for prostate cancer would be a well-accepted practice. However, current methods of screening for this cancer are controversial and has lead organizations like the U.S Preventative Service Task Force (USPSTF) and the American Cancer Society (ACS) to different guidelines for screening.
Palestine and the Jews God promised the land of Canaan to Abraham and his seed. (Gen. 12-17) Has that promise been fulfilled, or is it yet to be fulfilled by a return of the Jews to Palestine? Paul taught that God’s promise to bless humanity through Abraham’s seed and to make of them a great nation had been fulfilled. (Gal. 3:16) Both, Joshua and Nehemiah answered that question: “So the Lord gave to Israel all the land of which He had sworn to give to their fathers, and they took possession of it and dwelt in it…
Sir Francis Drake was a sailor and was the first to travel around the world. Drake was a Vice Admiral, he was second-in-command of the English fleet. He lived in america where Queen Elizabeth was. Drake and the queen were really close to the point that they had a relationship. Then one day the Spanish Armada said that they were gonna kill the queen. So what she said to get rid of them and to be back in 6 months. Sir Francis Drake went on the voyage to defeat the spanish for the queen.
There are times where specialists require some assistance in discovering the particular issues and states of their patients. At the point when specialists need to be certain about what their patients' conditions are, they take body liquid or tissue tests from them and forward these examples to the pathology advisors.
"Islam" is derived from the Arabic root salaama meaning peace, purity, submission and obedience. Islam stands for making peace by submitting to the will of God and obeying His law. Jews and Christians view Islam as the latest of the world's great religions. However, worldwide Muslims (sometimes written "Moslems") understand their universal religion as the "final religion" and the "primal religion."