Genetic And Environmental Factors Of Prostate Cancer

Testicular cancer is very rare it, and prostate cancer it can affect males age 15-35. Risk factors are history of one or both testes fail to descend, family history and is more common in white male than African American men. Treatments for prostate cancer depend on the aggressiveness of cancer and can range from surgery, radiation, and hormonal therapy. BPH treatments depend on the severity of is symptoms although it cannot be cured medications can help to shrink the prostate and surgical removal of the central part of the prostate can relive the symptoms, close monitoring until symptoms become a problem. BPH is caused by increased levels of testosterone at occur normally with increasing age, and is the most common cause of urinary obstruction of men 40 and older. Prostate cancer it is not entirely understood but it is caused by an unregulated growth of prostate cells, and is the most common male cancer. Common risk factors are hereditary; an increase age of 50 and older and is more commonly found in African American men then white. Treatments for testicular cancer depend on type of cancer or malignant or non-malignant, and stage of cancer but may include removal of the testicle and nearby lymph nodes sometimes fallowed by radiation

For example, age is the biggest factor. We all know that as men age and get older they run a higher chance of their prostate enlarging and developing cancer. Family history and race are also the other two big ones. If people in your immediate family have had the cancer, then you run a higher risk of contraction because you’re already genetically predisposed to getting prostate cancer. Also, African American men are more likely to be diagnosed with the cancer, with white and Hispanic men following behind. According to the CDC, from the years 1999-2013, black men had higher mortality and contraction rates than men of other races and ethnicities.1 Hormones are also a risk factor; should the male be producing a lot of testosterone could put him at risk.

In the case for PSA screening, PCa is the leading internal malignancy in US men and the second leading cause of cancer death in American men. Early detection of prostate cancers offers the best chance of cure. The PSA blood test is the best chance of cure. Currently, the PSA blood test is the best currently available way to detect PCa and it is easy, safe and inexpensive. PSA test results is a piece of information, it is what doctors do with the information that becomes the issue. However, the great majority of PSA detected tumors have the histologic characteristics of clinically important cancers. Also, PSA detection has found tumors early advancing the diagnosis by Seeral years (5-13) and prostate cancer mortality rates in U.S have decreased by 4% (patho book) since 1992, which is 5 years after initiation of prostate screenings. The dilemma is over treating the clinically unimportant disease versus under

The prostate is a walnut-sized gland that lies below the urinary bladder and surrounds the urethra. Along with the seminal vesicles, the prostate gland produces a fluid, called prostatic fluid, that contains, protects, nourishes, and supports the sperm. The white, sticky fluid originally from the prostate forms most of the volume of the semen. The prostate has no known function other than reproduction.

Prostate cancer is considered as the most commonly diagnosed cancer in men, in the U. S and most cases of prostate cancer have a good prognosis. Some of these cases can be aggressive and the death-rate is assessed to be 2.8%. The Prostate-specific antigen (PSA) test is used for screening for prostate cancer, to aid early detection and treatment.

Ultimately it is believed that aging is the leading risk factor, and males are at a higher risk to be

Unlike many other cancers and serious health problems, prostate cancer does not usually show its symptoms during the earlier stages of its development. This can make it a lot more dangerous than many other cancers and in the US; it ranks amongst the top four most commonly diagnosed cancers (alongside breast, colorectal and lung).

According to Ferrante, Shaw, and Scott (2011), prostate cancer is the most common cancer and second most common cancer death among men in the United States. Early detection permits appropriate and timely management, which can allow clinicians to treat the cancer effectively. When detected at early or regional stage, prostate cancer has a five-year survival rate of about 100%. Prostate-specific antigen (PSA) is the most widely used tumor marker and was approved by the FDA in 1994 as an aid in the early detection of prostate cancer (Duffy, 2011). PSA screening helps detect prostate cancer earlier, at lower clinical stages, and with a lower Gleason score (Cho et al., 2015).

PCa is a disease that effects only males due to the design of their reproductive anatomy. It has been said that every man would eventually develop PCa if they simply lived long enough; this is because the disease has a distinctive correlation with aging. PCa is the second leading cause of cancer death for men in the US. The American Cancer Society estimates about 180,890 new cases of PCa in the US for 2016, and 26,120

Prostate cancer is one of the major health concerns of the public. Worldwide prostate cancer has affected a big portion of the population and has become an issue for many males all around the world. Prostate cancer refers to the malignant growth of glandular cells located in the prostate. At the age of 85, a man is said to have a 1 in 5 chances of developing prostate cancer sometime in their life. Unfortunately Prostate cancer is a disease that does not give any warning signs when it is growing and so the clinical features of prostate are often nonspecific. Patients with prostate cancer have different types of treatment in which they can accept, there can be various methods such as surgery and theraypy toptions. There are

Men should talk with a doctor if they are 45 and at high risk for prostate cancer. This includes those with a family history, especially African American men.

They found that the solution lied in the saturation, where the maximal growth of the prostate cancer was achieved at a low level of testosterone. This model was produced by Fowler and Whitmore, who concluded “normal endogenous testosterone levels may be sufficient to cause near maximal stimulation of prostatic tumors.” There final conclusion was that “there is not today—nor has there ever been—a scientific basis for the contention that a higher T concentration causes pCA growth, acutely or long-term.” This was a pivotal statement because many other research labs began to do work on this same theory, the only downfall was the majority of them were finding similar results to the Huggins and Hodges, and Fowler and Whitmore. [9]

The same figure in women is 18% higher risk. The study covered 5.5 million Swedish men and women born between 1938 and 1991. Factors such as family history and obesity play a greater role in cancer risk.

There are men who can be in a percentile of having prostate cancer and unaware of what is going on with their body do to the lack of knowledge about prostate cancer. One main reason most men are unaware of the dangers of this illness is because it is not talked about enough amongst their peers. The advertisement is very veg to whom prostate cancer effects and may not be advertised enough. According to cancer.org there are about one in every seven men that will be diagnosed with prostate cancer in the ages of 65 and older, and it is rare before age 40. Prostate cancer is the second leading cause of cancer death in American men, behind only lung cancer. About one in every 36 men diagnosed will die of prostate cancer. Just as all men have a prostate all men should be aware of what the terms and symptoms of prostate cancer are and what can be done to help slow this growing illness.

Hypothesis/Objective: Prostate molecular markers have been first discovered using the cancer genome of individuals other than African American decent. Due to the lack of screening in a large cohort of AA PCa the prevalence of these markers in AA PCa is not known. Given the fundamental differences in the ancestral history of the genome of AA and EA the prevalence of these molecular markers may be markedly different. Conventional systematic sampling approaches may not reveal the true prevalence in AA PCa. Therefore, we propose to undertake an innovative approach using whole-mount radical prostatectomy to understand the racial disparity.