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What Are Mutations?

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Mutations are the foundation of evolutionary change, and the primary source of genetic variation. Mutations are changes in the nucleotide sequence that are permanent and can be passed on from mother to daughter cells during cell division. Mutations can also be passed from parent to offspring, which is if they occur in the reproductive cells. If the mutation that creates new genes that are beneficial, and allows an organism to respond to its environment better, then that new gene will have a higher probability of being passed on to future generations. The individuals that carry the beneficial allele will be more likely to survive and reproduce. This is the basis of natural selection, which allows organisms to produce adaptations in response …show more content…

A point mutation is a change in a single base pair within DNA, for example an A to T base pair has been substituted for a G-C base pair. There are many types of base pair mutations that can happen. One is known as a silent change that typically does not alter the amino acids and has no effect on the protein. Another base pair mutation is known as a missense mutation. This mutation is a base substitution where the amino acid is changed. For example, a Thr amino acid with the sequence ACC is now changed to Pro amino acid with the sequence CCC. A missense mutation can also be a functionally neutral mutation, this means that even though the sequence was changed, the amino acid stayed the same. For example, if a DNA sequence is changed from CCG to CCC the amino will stay the same, since both of these sequences code for Pro. Mutations can also occur that involve more than one nucleotide. These are called frameshift mutations. These mutations involve more than one nucleotide, so the amino acid sequence is changed and this usually has an inhibitory effect on the protein. A coding sequence that produced Pro Asp Pro could be changed to Ala Glu Arg. A simple addition or deletion of a series of nucleotides, shifts the reading frame when the mRNA is translated. Another mutation that can occur is an indel mutation which can be created by inserting or deleting a base pair of DNA or involve …show more content…

Chromosomes can cause mutations when they are changed. A mutation that can occur is gene duplication, this occurs when a chromosome has extra genetic material. Even though these gene duplications are rare, if they occur over the course of many generations this can lead to the formation of a gene family, which consists of two or more genes that are similar. An example of a duplication that causes a change in the phenotype is caused by a duplication on chromosome 17 which causes the disease known as Charcot-Marie-Tooth Disease. Another example of a mutation involving the chromosome would be the ploidy change, this occurs when the number of chromosomes an organism has changes. For example it goes from having two sets of chromosomes, then going to three or more sets of chromosomes. Down-syndrome is an example of the ploidy change, where the affected human has three sets of chromosome 21. Mobile elements can cause mutation in a DNA sequence. Mobile elements are strands of DNA floating around the cell that insert themselves in a functional gene and then disrupt its

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