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Naphthalene Inhalation Study

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Risk Assessment 1. Naphthalene is a white organic solid compound with a distinctive odor (ATSDR, 2005). Numerous results from the animal studies showed that naphthalene is potentially considered to be a human carcinogen. The studied indicated the fast absorption of naphthalene by inhalation, oral and dermal administration (22-73%; up to 84%; 50% respectively) (Preuss et al., 2003). Distribution of naphthalene occurs at fairly rapid rate without significant accumulation in body tissues (Preuss et al., 2003). Once absorbed, naphthalene undergoes metabolic activation and conjugation (Preuss et al., 2003). Naphthalene metabolites such as naphthoquinones prompt reactive oxygen species production that ultimately leads to DNA damage and carcinogenic transition of cells (Preuss et al., 2003). The US National Toxicology Program (NTP) reports indicate the results from long-term inhalation study conducted on rats that showed notably increased incidence of lung and nasal tumours (Preuss et al., 2003). Despite of the lack of human studies, the findings of the NTP allowed to admit naphthalene as a potential human carcinogen (Preuss et …show more content…

Average weight of an adult female of 66 kg is derived from the table “Average body weights, 1995 National Nutrition Survey”. Thus, daily consumption of naphthalene from tap water for 66 kg female is 700 µg / 66kg = 10.6 µg /kg /day. 3. The IRIS RfD totals 2E-2 mg/kg-day which converts to 0.02 mg/kg/day or 20 µg/kg/day. The value of 10.6 µg/kg/day is far less than acceptable dose of naphthalene established by the US EPA’s IRIS program. Therefore, there should be no health concern about naphthalene adverse effects and the tape water is safe for drinking. 4. According to the US EPA naphthalene was designated to Group C as “possible human carcinogen” (Preuss et al., 2003). This group includes chemicals with insufficient evidence of carcinogenicity in animals and the absence or little human data (EPA,

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