Necrotizing Fasciitis Research Papers

The clinical symptoms that will be seen with these patients are hyperthermia, tachycardia, tachypnea, hypertension, aggression, and agitation. Sometimes, these patients have been in this state for so long they may be acidotic or entering the early stages of rhabdomyolysis. These patients will have “super human” strength, appear as if nothing hurts them and they feel no pain, extremely diaphoretic (and often times naked due to hyperthermia), be extremely combative, and have what appears to be a complete disconnect from the outside world. Being in contact with these patients is extremely dangerous for EMS providers as they are so altered, they have no idea what they are doing and it is reported that they often times have paranoia and think that they are fighting for their lives.

How is it possible for a child to be born looking healthy to then rapidly age and die at an early age? Progeria, a genetic disease, is the answer. This rare disease causes premature aging and is fatal. By looking at the symptoms, the genetic cause, the research for a cure, and what you can do it, is possible to understand progeria.

Progeria, also known as Hutchinson Gilford Progeria Syndrome, and Progeria syndrome, is an extremely rare genetic disease wherein symptoms resembling aspects of aging are manifested at a very early age. The Progeria come from the Greek words “pro” meaning “before” and “gēras” meaning “old age”. The disorder has a very low incident rate, occurring in an estimated 1 per 8 million live births. Those born with Progeria typically live to their mid teens and early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited. Although the term Progeria applies strictly to all diseases characterized by premature aging symptoms, and is often used as

Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder where symptoms resembling aspects of aging are displayed at a very early age (Progeria 101). A genetic disease is an illness caused by one or more abnormalities in the genome, especially a condition that is congenital (present from birth). Genetic diseases are rare and may or may not be heritable. There are thousands of extremely rare genetic diseases, one being Progeria. Progeria affects its victims and their families more than physically; it takes a toll on the mental and emotional state of mind.

Necrotizing Fasciitis is a bacterial infection which causes the tissue under the skin to be destroyed. This flesh-eating infection is caused by more than one type of bacteria making it rare in many cases. Once the bacteria enter the body, it can quickly spread causing it to be deadly. The fascia, which is the connective tissue surrounding the blood vessels, nerves, fat, and muscles is infected making the body weak and lack support. In order to acquire this infection the skin needs to be broken such as getting a cut, scrape, or wound. With small injuries

Hutchinson Gilford Progeria syndrome (HGPS) is a very rare and destructive genetic disorder. It is progressive, causing children to age rapidly beginning 2 years after birth. Children with Progeria usually appear normal at birth, however by 1 year the signs and symptoms of Progeria begin. Symptoms of Progeria include short stature, bulging eyes, micrognathia, disproportion of head to body, alopecia, beaked nose, pathologic bone fractures, hearing loss, photophobia and hypertension. (Alves and others 2014) Progeria’s occurrence is 1 in 4 million to 1 in 8 million live births and males are more frequently affected than females. The average life expectancy for a child with Progeria is about 13. (King 2013) However some with the disease die younger and some live to be 20 years or older. Death in Progeria is primarily caused by heart attacks and atherosclerosis. Atherosclerosis is a disease in which the arteries become hardened. (Bhimji 2011)

As of 2012, Progeria Research Foundation provided over 3 million dollars for progeria related research projects performed in many states and in 6 other countries. As of right now, there are not any treatments to help cure progeria but there are some medications to help some of the problems such as arthritic, respiratory, and cardiovascular problems and to help make people living with progeria more comfortable. Doctors suggest that children with Progeria take aspirin to help with their heart health. Once the child has hypertension, strokes or seizures, the child will take medicines similar to what adults would take for these

Imagine not being able to do anything without help or independently. Wolf-Hirschhorn syndrome is a negative mutation of the body. It is a condition that affects the body in many ways.

In 1886, the first case of Progeria was diagnosed by Dr. Jonathan Hutchinson. Progeria is a pre-mature aging system which is both rare and fatal. He began documenting features of a six year old boy who had symptoms of hair loss and atrophy of skin. Then, in 1897, Dr. Hastings Gilford pronounced Progeria as a clinical entity. The name Progeria comes from the Greek term “progeros" meaning, “prematurely old”. Virtually nothing was known about Progeria 30 years ago. Since it is an extremely rare disease, research didn’t begin until the 1990’s. This very rare disease occurs during childhood and is characterized by dramatic, premature aging. Hutchinson-Gilford progeria syndrome (HGPS) is the most severe form of the disease. Currently, the condition

What a great article with lots of information on Necrotizing fasciitis (NF). I have similar experience with NF as you which is none. I found the review and article of “Necrotizing fasciitis: How reliable are the cutaneous signs?” very interesting as a future practitioner. Your review outlined the main points of the article and provided some great insight to NF.

Necrotizing fasciitis (NF) has been called the “flesh eating bacteria” by the media. This past summer there were a few cases of this on Galveston beaches. Most likely it was caused by the strain Dr. Edlich talks about in his paper Necrotizing Fasciitis: Background, Pathophysiology, Etiology. He describes it as “a variant necrotizing Type I, or poly microbial strain known as Type I Saltwater Necrotizing Fasciitis, in which a minor skin wound is infected with saltwater containing a Vibrio species.” The National Necrotizing Fasciitis Foundation (NNFF) states that in actuality it is the “decaying infection of the fascia” and not a “flesh eating bacteria.” It does not just affect the fascia, the outer connective tissue bands covering the muscles, and other soft tissues, but it also can destroy the surrounding soft tissues such as skin, fat, blood vessels and nerves. NF is not easily diagnosed and it spreads quickly usually using the fascia as an expressway. It is still a relatively rare disease

Gas gangrene is a devastatingly fast moving disease that presents with rapid cell death around the site of infection; Clostridium perfringens is the scientific name for one of most common bacteria that causes gas gangrene, showing up in four out of five cases. If not treated quickly, gas gangrene can cause death within the first day of infection (Carlisle, 2014). C. perfringens is a nonmotile, gram positive, rod shaped bacteria (The Public Health Agency of Canada, 2011). Its virulence factors include alpha toxin, which causes the neutrophils of the body to be mistrafficked and unable to enter the infected tissue as well as causing vasoconstriction, which inhibits necessary blood flow to infected tissues, thus greatly slowing down the healing process (Titball, Naylor, & Basak, 1999).

Necrotizing Fasciitis, also known as the flesh-eating disease is developed from open wounds that get infected with bacteria. This rare disease also depends on the human system considering the fact of how healthy the person is in determining the low chances of having the disease. The infection is not only made up of one type of bacteria but a variety for example, Clostridium, Staphylococcus, to mention a few among others more. If lead to serious infection it can result to death or a loss of a limb. The best way to prevent this deadly infection is to keep open wounds clean and covered with bandages until it is healed. Symptoms of this disease may include pains of the muscles also the skin can turn red or purple and swell rapidly. This kind of

To the vendors point does percent necrosis really matter? If the block has a decent amount of the appropriate tissue or tumor then it should be acceptable for the project. We could have the pathologists mark the necrosis on the H+Es while reading during QA and then cut those portions out of the block at a later point in time. The focus of the QA process should be on getting the right tissue and tumor type needed for the study. That is the main problem the new QA process was to solve.

dangerous scarlet fever. It’s an old disease that was first described by Hippocrates in 400 BC.