I have selected to discuss Niemann-Pick type C because I am unfamiliar with it
1. Describe the symptoms/outcomes of the disorder.
Symptoms - Enlarged Spleen, Enlarged liver, Loss Of Muscle Tone, Difficult Moving Limbs, seizures,delayed motor development beginning before age 2
2. Identify the organelle that is affected.
The Endoplasmic Reticulum (smooth)
Niemann-Pick type C affects lipids within the cell. According to nnpdf.org " NPC Patients are not able to metabolize cholesterol"
3. Discuss the normal function of this organelle and how its function is disrupted.
The ER makes lipids, breaks down and packages proteins for the Golgi complex. The Golgi Complex processes and transports and proteins out the cell. (Nnpdf.org, 2016)
4. What conclusions can you draw about the importance of this organelle in the cell?
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The heart, nails, musicals, and hair use protein. SO DEATH!! (Nnpdf.org, 2016)
The smooth Endoplasmic Reticulum makes lipids and steroids like cholesterol. ------ This is key! (Nnpdf.org, 2016)
5. Based on what you have learned about cell structure, predict how a cell from this disorder would look like under the microscope.
I think the cell from NPC would look like clusters of bumps attacking the smooth Endoplasmic Reticulum
6. Based on the cell biology, what options do you have to treat the disorder?
NPC currently does not have a specific treatment. (Parseghian.org,
If my hypothesis is supported, the images of PKCγ-Cγ1 will show the PKCγ spread towards the edges of the cell and be less concentrated in the middle. The images of fascin-FTIC will show that the fascin has moved toward the edges of the cell along with the PKCγ. Layered images will show the overlapping of of PKCγ and fascin, suggesting a strong interaction between the two proteins. A magnified inspection of the edges of the cell will show both PKCγ and fascin have concentrated in the protrusions of the cell
?: Mitochondria gives the energy, Cytoskeleton is made up of muscle cells, and smooth ER gives the calcium to muscle cells in order to have muscle
Instructions: Write a 1 page, double spaced, summary about the function of one organelle in the cell and how it was discovered.
Discussed in chapter 12, are the different compartments of the cell, the explanation of how proteins are guided to specific organelles, and a discussion of how proteins cross cell membranes. Within a cell, the intracellular compartments are the plasma membrane, cytoplasm, endoplasmic reticulum (ER), nucleus, Golgi apparatus, mitochondria, endosome, lysosome, peroxisome, cytosol, and free ribosomes. The plasma membrane encloses all the intracellular compartments within this membrane contains the cytoplasm. The nucleus contains the genetic information, such as DNA. The mitochondria are known as the “power house”; this is where ATP is generated in most cells. The lysosome is a digestive enzyme that is active at an acidic pH. The peroxisome is also an enzyme that produces and degrade hydrogen peroxide.
The endoplasmic reticulum is a organelle inside the eukaryotic cell. This organelle has many important jobs but the main one is to deliver carbohydrates such as protein to other organelles like the plasma membrane and the golgi apparatus. Some other functions this organelle does is play a vital role in the skeletal structure and also provides increased surface area for cellular reactions. There are two main types of endoplasmic reticulum, smooth and rough endoplasmic reticulum. Rough ER manufactures and packages the proteins, it can manufacture and do this because it has ribosomes all over it which enable it to make the proteins. The smooth ER stores steroids and ions, it also has muscle cells which stores ions and releases them when the muscle
Much of this process is done by the Golgi apparatus, one of the essential organelles of a living cell. The Golgi complex contains a numerous number of these vesicles. These vesicles are then used to transport different molecules to the cellular membrane. At the cellular membrane, these vesicles are then excreted. Larger secretory that are found are used for selective excretion. Furthermore, the vesicles mediate the sorting of molecules because the Golgi apparatus is
Plant cells and animal cells contain an organelle called the Smooth Endoplasmic Reticulum. “The role of the smooth endoplasmic reticulum is to make cellular products like hormones and lipids.” This is then shared to the cell. Calcium ions are also released from the smooth ER as well as processing toxins. The difference between a smooth ER and a rough ER is that the rough endoplasmic reticulum has ribosomes for protein synthesis on its surface.
According to the color of cell.Phases is prophase. On prophase everything are mixture together and there is no division.The image it shows color of black on the cell.whitefish blastula showing spindles.But also i can see the shape of the cell it almost like the circle one by one compose together with arrange.On the observation if watching carefully able to see some cell nucleus.And the happened is cytomembrane surround with the cell nucleus.
When creating my game I included 8 organelles that are found in the cell. One of these organelles is the nucleus. The nucleus is a large membrane-enclosed structure that contains genetic material in the form of DNA and controls many of the cell’s activities. The job of the nucleus is to protect the DNA and the RNA from anything outside the nucleus. Another organelle is the ribosome. Ribosomes are small particle of RNA and protein found throughout the cytoplasm in all cells. The ribosome is responsible for making protein by following the coded information from the DNA. The endoplasmic reticulum is where lipid components of the cell membrane are assembled, along with proteins and other materials that are exported from the cell. The endoplasmic reticulum is in charge of
In the beginning of the article, the writer describes the main function of lysosomes and how lysosomes relate to other organelles in other types of cells. In the writer’s words, “Lysosomes are found in animal cells...In plant and fungal cells, a similar type of function is carried out inside vacuoles”(p. 1).
This is what allows prokaryotes to attach to other surfaces. Cytosol is a water like fluid found in the cytoplasm. Cytoplasm is inside the plasma membrane but outside the nucleus. The cell wall is made of polysaccharides just outside the plasma membrane and its made of cellulose. (Cundy, 2012) The plasma membrane is the outer boundary of the cell with a layer made of phospholipids. DNA is a double polymer of nucleotides that store genetic information. DNA stands for Deoxyribonucleic Acid with a phosphate group of four nitrogenous bases which are adenine, cytosine, guanine, and thymine. The largest organelle is the nucleus. The nucleus contains DNA. The mitochondria have a double membrane and it is known for supplying energy to the cell. Ribosomes produce proteins. These ribosomes can be found in the cytosol of cells. The nucleolus is what makes ribosomes and RNA. Lysosomes have digestive enzymes. The endoplasmic reticulum is an inner membrane system that makes some proteins. (Cundy, 2012) There are two endoplasmic reticulum, one is rough and the other is smooth. The rough endoplasmic reticulum has ribosomes on it while the smooth endoplasmic reticulum does not have ribosomes on them. The Golgi apparatus prepares proteins to be taken out of the cell. The vacuole is storage for water and other nutrients a call may need and this is most commonly found in plant cells. The cytoskeleton shapes the cell wall and consists of protein
2) Endoplasmic reticulum/ Golgi complex: The endoplasmic reticulum (ER) is responsible for the modifaction of fats and lips, the
The golgi body packages proteins and carbohydrates into membrane-bound vesicles for “export” from the cell.
This disease can affect the ability of children to learn [4], may delay their physical growth and
The gunk contained many fibrous cells, these cells were from the broken down cells. Also it contained debris in the sample from the dirt, but did not see other organelles. In pallet one, as a group we were able to see nuclei of cells that were the brown spots in the diagram. Starch was also seen which was in purple, and we continued to see more debris. The first pallet is referred as the nuclear palette since it contained a vast amount of nuclei. The last palette contained starch particles that were coloured in dye, and also contained mitochondria, which were the small dots and lines. The objects, organelles and other structures that were observed within the supernatant 2 sample were mainly ribosomes because once the sample was centrifuged they were segregated and brought to the top of the