I have selected to discuss Niemann-Pick type C because I am unfamiliar with it
1. Describe the symptoms/outcomes of the disorder.
Symptoms - Enlarged Spleen, Enlarged liver, Loss Of Muscle Tone, Difficult Moving Limbs, seizures,delayed motor development beginning before age 2
2. Identify the organelle that is affected.
The Endoplasmic Reticulum (smooth)
Niemann-Pick type C affects lipids within the cell. According to nnpdf.org " NPC Patients are not able to metabolize cholesterol"
3. Discuss the normal function of this organelle and how its function is disrupted.
The ER makes lipids, breaks down and packages proteins for the Golgi complex. The Golgi Complex processes and transports and proteins out the cell. (Nnpdf.org, 2016)
4. What conclusions can you draw about the importance of this organelle in the cell?
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The heart, nails, musicals, and hair use protein. SO DEATH!! (Nnpdf.org, 2016)
The smooth Endoplasmic Reticulum makes lipids and steroids like cholesterol. ------ This is key! (Nnpdf.org, 2016)
5. Based on what you have learned about cell structure, predict how a cell from this disorder would look like under the microscope.
I think the cell from NPC would look like clusters of bumps attacking the smooth Endoplasmic Reticulum
6. Based on the cell biology, what options do you have to treat the disorder?
NPC currently does not have a specific treatment. (Parseghian.org,
If my hypothesis is supported, the images of PKCγ-Cγ1 will show the PKCγ spread towards the edges of the cell and be less concentrated in the middle. The images of fascin-FTIC will show that the fascin has moved toward the edges of the cell along with the PKCγ. Layered images will show the overlapping of of PKCγ and fascin, suggesting a strong interaction between the two proteins. A magnified inspection of the edges of the cell will show both PKCγ and fascin have concentrated in the protrusions of the cell
?: Mitochondria gives the energy, Cytoskeleton is made up of muscle cells, and smooth ER gives the calcium to muscle cells in order to have muscle
Instructions: Write a 1 page, double spaced, summary about the function of one organelle in the cell and how it was discovered.
The first pathway transports proteins between the cytosol and the nucleus by way of nuclear pore complexes in the nuclear envelope. With protein translocation, the protein directly transports to an exact protein across the membrane. Vesicular transport is where the spherical transport vesicle becomes loaded with cargo within the lumen. An example of this pathway, soluble proteins from the ER to the Golgi apparatus by way of transport vesicles. The pathways require energy this can be supplied by ATP hydrolysis. Chaperone proteins facilitate in passing proteins to other
The endoplasmic reticulum is a organelle inside the eukaryotic cell. This organelle has many important jobs but the main one is to deliver carbohydrates such as protein to other organelles like the plasma membrane and the golgi apparatus. Some other functions this organelle does is play a vital role in the skeletal structure and also provides increased surface area for cellular reactions. There are two main types of endoplasmic reticulum, smooth and rough endoplasmic reticulum. Rough ER manufactures and packages the proteins, it can manufacture and do this because it has ribosomes all over it which enable it to make the proteins. The smooth ER stores steroids and ions, it also has muscle cells which stores ions and releases them when the muscle
Much of this process is done by the Golgi apparatus, one of the essential organelles of a living cell. The Golgi complex contains a numerous number of these vesicles. These vesicles are then used to transport different molecules to the cellular membrane. At the cellular membrane, these vesicles are then excreted. Larger secretory that are found are used for selective excretion. Furthermore, the vesicles mediate the sorting of molecules because the Golgi apparatus is
“The secretory vesicles store molecules and proteins from the endoplasmic reticulum and the Golgi apparatus until the cell is ready to release them. “
According to the color of cell.Phases is prophase. On prophase everything are mixture together and there is no division.The image it shows color of black on the cell.whitefish blastula showing spindles.But also i can see the shape of the cell it almost like the circle one by one compose together with arrange.On the observation if watching carefully able to see some cell nucleus.And the happened is cytomembrane surround with the cell nucleus.
The golgi apparatus is an organelle that modifies, sorts, and packages proteins and other materials from the endoplasmic reticulum for storage in the cell or release outside the cell. The job of the golgi apparatus is to package the proteins so that they are able to travel out of the cell. The vacuole can be found inside the cell. The vacuole is a saclike, membrane-enclosed structure. The vacuole is in charge of storing materials like water, salts, proteins, and carbohydrates. Another organelle found in the cell is a lysosomes. A lysosome is a small organelle filled with enzymes. This organelle breaks down lipids, carbohydrates, and proteins into small molecules that can be used by the rest of the cell. The cell wall is an important organelle in the plant cell. The cell wall is a strong supporting layer around the membrane. The cell wall is responsible for protecting the cell and providing structure to the cell. Lastly, the vesicles are very important to the cell. Vesicles are membrane enclosed storage organelles that are smaller than vacuoles. The job of vesicles is to store and move materials between organelles and to and from the cell
Lysosomes and vacuoles break down amino acids and proteins to be recycled to make new proteins. Phagocytosis is when cells deal with the remains of dead cells. Dead cells are broke down in lysosomes to be recycled to be “reused as building materials or as nutrients for energy.”(p. 1).
This is what allows prokaryotes to attach to other surfaces. Cytosol is a water like fluid found in the cytoplasm. Cytoplasm is inside the plasma membrane but outside the nucleus. The cell wall is made of polysaccharides just outside the plasma membrane and its made of cellulose. (Cundy, 2012) The plasma membrane is the outer boundary of the cell with a layer made of phospholipids. DNA is a double polymer of nucleotides that store genetic information. DNA stands for Deoxyribonucleic Acid with a phosphate group of four nitrogenous bases which are adenine, cytosine, guanine, and thymine. The largest organelle is the nucleus. The nucleus contains DNA. The mitochondria have a double membrane and it is known for supplying energy to the cell. Ribosomes produce proteins. These ribosomes can be found in the cytosol of cells. The nucleolus is what makes ribosomes and RNA. Lysosomes have digestive enzymes. The endoplasmic reticulum is an inner membrane system that makes some proteins. (Cundy, 2012) There are two endoplasmic reticulum, one is rough and the other is smooth. The rough endoplasmic reticulum has ribosomes on it while the smooth endoplasmic reticulum does not have ribosomes on them. The Golgi apparatus prepares proteins to be taken out of the cell. The vacuole is storage for water and other nutrients a call may need and this is most commonly found in plant cells. The cytoskeleton shapes the cell wall and consists of protein
The golgi body packages proteins and carbohydrates into membrane-bound vesicles for “export” from the cell.
This disease can affect the ability of children to learn [4], may delay their physical growth and
The gunk contained many fibrous cells, these cells were from the broken down cells. Also it contained debris in the sample from the dirt, but did not see other organelles. In pallet one, as a group we were able to see nuclei of cells that were the brown spots in the diagram. Starch was also seen which was in purple, and we continued to see more debris. The first pallet is referred as the nuclear palette since it contained a vast amount of nuclei. The last palette contained starch particles that were coloured in dye, and also contained mitochondria, which were the small dots and lines. The objects, organelles and other structures that were observed within the supernatant 2 sample were mainly ribosomes because once the sample was centrifuged they were segregated and brought to the top of the
2) Endoplasmic reticulum/ Golgi complex: The endoplasmic reticulum (ER) is responsible for the modifaction of fats and lips, the