Drug Discovery Pioneer Exercise Ryan Stephens 21276916 Felix Hoffmann was born January 21, 1868 in Ludwigsburg, Swabia, Germany. Although his family did not come from a medical or scientific background (his father was an industrialist), it has been said that Hoffmann was searching for a drug to relieve his father’s arthritis pain. Hoffmann studied at the University of Munich and in 1891, Hoffmann graduated magna cum laude (“with great praise”) with a degree in Chemistry. Two years later in 1893, he received his doctorate, also magna cum laude, after completing his thesis, “On Certain Derivatives of Dihydroanthracene”. Hoffman is most well-known for his role in the discovery and creation of Aspirin while at Bayer. He started his journey …show more content…
• it is often used to help prevent heart attacks, strokes and blood clots because of its antiplatelet effect Aspirin has had a profound effect on clinical practice Aspirin is now used post-surgery after percutaneous coronary interventions to prevent blood clots. Aspirins usability has created a trickledown effect allowing people being able to control their own pain with the drug, it has would resulted in less people having to come to clinical practices with more minor problems subsequently therefore allowing doctors to focus on serious cases. Also, as Aspirin reduces pain, fever and inflammation, it has reduced the amount of time patients stay in hospitals to recover. There has been little evolution and innovations in terms of Aspirin’s formula. It has not been changed since Hoffman’s discovery! However its form has been improved whilst originally sold as a powder, in 1915 Aspirin was produced as a tablet. Also, while the drug itself has not been modified, the knowledge about it has. It was not until the 1970’s that scientists began to understand how aspirin works, and in 1982, the scientist responsible for the findings, Professor Vane, won the Nobel Prize for Medicine for his …show more content…
The end of Hoffman’s story unfortunately ends quite sadly. Although his discovery had such a profound effect on the world Hoffman’s legacy is rather understated, to this day the inventor of Asprin has remained to some extent faceless. Having never married, nor had children, Felix Hoffmann died February 8, 1946 in Switzerland, out of the public eye. References Chemheritage.org,. 2014. 'Felix Hoffmann | Chemical Heritage Foundation'. http://www.chemheritage.org/discover/online-resources/chemistry-in-history/themes/pharmaceuticals/relieving-symptoms/hoffmann.aspx. Communications, Bayer. 2014. 'Felix Hoffmann - Bayer'. Bayer.Com. http://www.bayer.com/en/Felix-Hoffmann.aspx. Drugs.com,. 2014. 'Aspirin Uses, Dosage, Side Effects & Interactions - Drugs.Com'. http://www.drugs.com/aspirin.html. Inventors.about.com,. 2014. 'History Of Aspirin'. http://inventors.about.com/library/inventors/blaspirin.htm. Rainsford, K. D. 2004. Aspirin And Related Drugs. London: Taylor &
The manufacturing of Neoprontosil and other products took place at the Winthrop Chemical Company Inc.. The company was a 50/50 joint venture of Sterling-Winthrop, also known as Sterling Drug, and I.G. Farben, a conglomerate formed in 1926 through the merging of eight leading German chemical manufacturers including Bayer, a German chemical and pharmaceutical company. [6, 13] I.G. Farben was notorious for its role in the Holocaust as it was involved in many war crimes. The company produced large quantities of Zyklon B, a cyanide-based pesticide, necessary for the gas chambers at various concentration camps during the Holocaust. [14] Sterling-Winthrop was an American pharmaceutical company founded in 1901 by William E. Weiss and Albert H. Deibold to manufacture and sell a pain-relieving preparation called “Neuralgine”. [15]
He was a hard working student, but not the best. He received a doctorate degree in 1847. He also spent lots of time related to research on tartrate acid. He found different ways to kill many different germs. He found cures for rabies and anthrax and found a way to pasteurize milk. That saved many lives.
During the 1890s Felix Hoffman a chemical engineer who worked at the Bayer Company located in Germany was looking to help his father who was suffering from arthritis. He discovered how to isolate acetylsalicylic acid in a digestible form.. Starting in 1899, the Bayer company began to sell an aspirin powder to doctors to provide to their patients. The drug became a hit and, in 1915, it was sold as over-the-counter
Third, sodium pentothal was founded in the early 1930s by Ernest H. Volwiler and Donalee L. Tabern, working for Abbot Laboratories. It was first used in humans on March 8, 1934, by Dr. Ralph M. Walters in a study of its properties. Three months later, Dr. John S. Lundy started a clinical trial of thiopental at the mayo Clinic at request of Abbott. (Wikipedia, 2010)
Albert Hofmann is a chemist who creates the drug LSD in 1938. He attends the University of Zurich and studies chemistry for four years. After college, he begins working at Sandoz Laboratories and develops the drug LSD there. After he creates the drug, he tests it on himself and rides his bicycle home from the lab. Albert then discoveres ‘ethacetin,’ which is an ‘intoxicating tryptamine.’ He wins many awards later in his life such as the Scheele Award. While examaning details about Alabert Hofmann, many may concur that the events pertaining to his early personal life, career and major works, and awards are very interesting.
was discovered in the 19th century by a Chemist called James Marsh. His development of the
The disorder was first discovered in Norway 1934, by Dr.Asjor Folling. Folling was first trained as a chemist and later studied medicine. He held a professorship of nutrient research at the University Hospital in Norway. Their where not many facts on Folling other than stories told by his son of how he discovered the
Otto Heinrich Warburg in 1923, and received the Nobel Prize but of course people do not know about it. What he discovered he? He discovered that the body acidic environment is an environment without oxygen. So if you just take 35% oxygen an organism then for two days, you can create cancer. He discovered that cancer cells can not survive with high concentrations of oxygen.
His life was just like other normal people back the, such as making a big contribution, or simply as making something very small. Everybody looked up to him to make a vaccine to help other people. He also had many obstacles to overcome such as finding the correct cell or finding the correct particle. Also another challenge was seeing his 3 kids die from a bad fever. Which led to him to make other vaccines so that people like him wouldn’t go through the same problem. (inventors.about.com) Also he had a bad education, which could have changed the tide of his life. Back then you usually got home schooled. Plus the books and stuff back then was horrible. But he was a very clever to figure out so many things in his life. Also to show how brave and good he was, he saved a 9 year old kid from dying because he had rabies.
According to Nordqvist,Medicalnewstoday,(2015); Aspirin is a still till this day a very well known and popularly used medication in the world. As an over the counter or (OTC) product since 1915. Aspirin was discovered in 1763 by Edward Stone, he had been documenting his symptoms his been having such as fever, pain, chills, and fatigue when he had discovered Salicylic Acid which is the main reactant in Aspirin. As the years passed many other Salicylate Medicines have been discovered such as Salicin and Sodium Salicylic acids. Many forms of aspirin were created such as capsules and chewable gummies.
Paul Ehrlich is a German Jewish medical scientist best known for finding the first most effective treatment for syphilis for which he got the Nobel Prize for Physiology or Medicine in 1908 with his accomplice Élie Metchnikoff. Paul ehrlich made huge commitments to comprehension cancer, including building up a strain of mouse tumor cells known as Ehrlich ascites cells that are still utilized as a part of growth exploration. Ehrlich's work with the selectivity of staining dyes for particular cells, and the particular tying of one antigen to stand out antibody, which prompted the theory that it ought to be conceivable to create drugs that were so particular to ailment cells that they could be viewed as "magic bullets." For his understanding and
My chemist Luis Federico Leloir Luis Federico Leloir was born on September 6, 1906, at 81 Avenue Victor . Leloir graduated from the University of Buenos Aires medical school in 1932. While performing research at its Institute of Physiology from 1934-35, he worked alongside Professor Bernardo A. Houssay, who influenced his interest in adrenalin carbohydrate metabolism. Leloir spent a year at the University of Cambridge's Biochemical Laboratory before returning to the Institute of Physiology, where he studied the oxidation of fatty acids. After traveling to the United States in 1944, he worked as a research assistant in St. Louis, Missouri, and at Columbia University's College of Physicians and Surgeons in New York. Leloir won the Nobel Prize
On December 28, 1895, Roentgen delivered a written presentation of his discovery to the Physical – Medical Society of Wurzburg. Within a few weeks, this Preliminary Communication entitled
Karl Landsteiner dedicated most of his life to working in science. He was born in Vienna on June 12, 1868. Landsteiner’s interest in science rocketed as he began his studies at the University of Vienna. He graduated from there in 1891. While studying at the university, his focus of study was biochemical research. In fact, Landsteiner is known at the founder of biochemistry. After graduating from the University, he believed it would suit him best to leave Vienna and work in labs. The lab work he performed furthered his education and provided him with experience he would not have been able to obtain elsewhere. Landsteiner’s time in the labs did not last long before he returned to Vienna, where he began working in hospitals which sparked his interest in immunity and the nature of antibodies. A
Alexander Fleming was born on August 6, 1881 to Hugh Fleming and Grace Morton. His parents shared the same occupation as farmers. He was born on a rural farm in Lochfield in East Ayrshire Scotland. Alexander or Alec as his family called him had three siblings Grace, John and Robert. He also had four half siblings Jane, Hugh, Thomas, and Mary who were from his father’s previous marriage. Alexander’s education began at Loudoun Moor School, then he moved to a larger school called Darvel School. He also moved to Kilmarnock Academy. After this he relocated to London where he attended Regent Street Polytechnic. Before starting his medical studies he worked at a shipping office. Alexander began his medical studies in 1901 at St. Mary’s Hospital Medical School at the University of London. In 1908 he was acknowledged with the gold medal as the top medical student. After graduating his dream job was to become a surgeon but, a short term opportunity in the laboratories of the research department at St. Mary’s Hospital. A bacteriologist and immunologist named Sir Almroth Edward Wright influenced Alexander. Sir Wright had amazing ideas of vaccine therapy that would create an extraordinary change in the field of medical treatment. After this he decided to open his own private practice as a venereologist, this was between 1909 and 1914. As a venereologist he became one of the first doctors to use arsphenamie (Salvarsan) which was given to treat syphilis. The drug was discovered by German