Polio Summary

Polio an American story is a scholarly readable and informative book which covers the lives of many American eminent scientists who struggled a lot to eradicate polio. This book mainly focuses on the mid twentieth century where the people are very eager to find a vaccine to eradicate polio .This book also covers the entire topics from appearance of polio symptoms to post polio syndrome which shows the valuable thesis done by David M. Oshinsky.

Paralytic poliomyelitis, "polio", held a reign of terror over this nation for decades. But unless you were born before 1955, polio may seem to be just another ephemeral disease that has been nonexistent for years. Those born before 1955 remember having a great fear of this horrible disease which crippled thousands of once active, healthy children. This disease had no cure and no identified causes, which made it all the more terrifying. People did everything that they had done in the past to prevent the spread of disease, such as quarantining areas, but these tactics never seemed to work. Polio could not be contained. Many people did not have the money to care for a family member with polio. This was one of the

In addition to health-related advances, such as the artificial heart valve, DNA structure decay, penicillin, and antibiotics. As well, we can not forget the start of the fight with cancer by the memorable world’s first cancer treatment with Cobalt-60 radiation. Although, new surgical procedures were introduced like the first successful kidney transplant and immunizations like typhoid, smallpox, tetanus, and polio vaccines. Polio epidemics had been occurring in the United States since 1916 according to the Centers for Disease Control and Prevention. The viral disease struck even important figures as President Franklin Roosevelt that forced him to use a wheelchair and wear steel braces on his legs privately. “In the 1940s and 1950s, widespread polio epidemics terrorized the nation. Finally, research scientist Jonas Salk developed an injectable vaccine to prevent polio. In 1955 the vaccine became available to the general public. American scientist Albert Sabin then developed an oral vaccine for polio. Safer and more convenient than Salk’s injection vaccine, the Sabin vaccine became the most common method for preventing the disease. The threat of polio nearly disappeared and many more diseases no longer affected the American people” (Appleby, Joyce 2004). Therefore, the treatments and cures of several epidemics and diseases were an important factor that caused the Baby Boom due to the decrease in the children’s mortality rates and their possibility to reach adult

Death, sickness, and epidemics were very prominent during the Progressive Era. America was going through a very rough time because of the increase in health risks. With all this happening America was recovering from World War One and the Financial Crises in the business community. During 1916 America experienced one of its first epidemics with a large case of polio, causing nearly 3000 deaths with over 9000 cases. This epidemic could have been caused due to the Public’s Health being poor during the Progressive Era, this was due to the lack of basic human sanitation, poor living conditions, and the rarity of children’s medical institutions (Healthcare).

Heather Green Wooten’s The Polio Years in Texas: Battling a Terrifying Unknown chronicles the history of polio in Texas in a very extensive timeline. The book goes all the way back to the beginning of the polio epidemic and essentially progresses to the present. The time in this book certainly exceeds that of, The Captured and Isaac’s Storm. The Captured chronicled a long period of captivity, but did not appear to exceed a decade. Isaac’s Storm traced the initial development of Weather Bureau and covered a great period, but did not exceed that of The Polio Years. Several themes begin to emerge further into the book. Obvious themes included, the support for March of Dimes, impact on families affected by polio, the growth and development of rehabilitation facilities, and more importantly the response to the disease by Texans. Oddly, Wooten discusses the fact that other diseases such as, measles, diphtheria, and tuberculosis took more lives than Polio. However, people feared Polio more than the rest. Wooten attributes polio’s terrifying affect to the uncertainty. Several uncertainties such as, how to prevent it, why did some become crippled, why did some die, and why did it only essentially affected children made polio very terrifying in the 20th century. Texas appeared to have been hit the hardest in comparison to other states. Wooten’s research examined the time during and then after World War II. During this period, Texas saw an immense amount of polio contractions. Per

Polymyelitis, otherwise known as polio, was one of the most feared diseases of the early to mid twentieth century. This disease either killed or it paralyzed its’ victims. This affected America in such a terrible way by killing or paralyzing thousands of them within the beginning of the twentieth century alone, scaring most other Americans and putting up a red flag for most health organizations. President Roosevelt, however, conceived the idea of initiating the charity that would later

Poliomyelitis was a highly infectious disease that spread through many Americans in the early 20th century. As a matter of fact, over 3,000 Americans died of the disease each year. Families were overwhelmingly desperate for doctors to find a cure. When one suffered from polio, they generally experienced painful symptoms which included not only fatigue and muscle weakness, but even death. Therefore, when the polio vaccine was introduced by scientist Jonas Salk in 1953, it greatly contributed to Americans in numerous positive ways. Environmentally, the vaccine saved countless young American lives affected by the disease thus decreasing American mortality rates. Socially, the polio vaccine convenienced families who were either directly afflicted

First and foremost, I thoroughly enjoyed Guerrini's "Polio and Primates" and found it to be both informative and engaging. I did not realize prior to the reading that the path to the polio vaccine was a rushed and flawed one. I wonder how much the misinformation spread across the scientific and non-scientific communities alike as a result of Flexner's research truly "delayed the understanding of polio's complex clinic and epidemiological features" (p. 119). The reading also left me curious as to how the trajectory of polio research would have changed if President Roosevelt had never contracted it during his presidency, since his prominence ultimately led research on the virus to become a national priority. The subsequent public pressure to develop a vaccine further rushed its development with the promise to

Polio, something that can devastate anyone and everyone so very quickly. In 1953, you didn’t know when you could be infected with this life threatening disease.

With a substantial amount of preventive healthcare advancements behind them, the American medical community turned its attention to the deadly polio virus plaguing America. From 1937 to 1952, known cases of Americans contracting polio skyrocketed from ten thousand to a staggering figure of roughly fifty-seven thousand cases. Of those cases within that time period, approximately one thousand five hundred deaths as a result of polio were recorded. In the year 1953, The National Foundation for Infantile Paralysis provided the scientist Dr. Jonas Salk with the tools necessary to research, and develop a working vaccine to combat the devastating polio disease. After much trial and error, Dr. Salk was finally able to create what he felt was a successful polio vaccination, and proceeded to conduct a field test. After resounding success, manufacturing instructions for the Salk vaccine were sent to a series of scientific laboratories for immediate production and administration to American children. The disaster that occurred next will forever be known through American medical history as the Cutter Incident (named so after one of the labs that administered the polio vaccine). This medical crisis sent shockwaves throughout America and the medical community, and numerous lawsuits were filed against Cutter Laboratories, resulting in fewer and fewer labs willing to accept contract work in developing vaccines.

Roosevelt became president with infantile paralysis (polio), which was diagnosed in 1921, and the public found out.9 Having the American people's president seem weakened by such a disease but push on through expectations showed that little to nothing was going to get in his way and stop him.10 Including FDR's case, close to 25% of those age 21 and older had paralytic cases by the early 1950s.11 Before the vaccine, there was a peak of about 50,000 cases of polio in 1953.12 Concern of the people was also around it's highest point due to the increasing risk of the horrid disease most feared at this time. Hopes for a solution were still going strong. Friends, family, and even strangers kept prayers for those in need. Anything that could be done was done until the vaccine was established. There were even several hundred thousand children placed in a control study and out of the 749,000, only 33 from the vaccinated group developed paralytic polio.13 In addition to this trial and other performed, and conclusion was drawn stating that the vaccine was 80-90% effective against the paralytic branch of polio.14 Chances for a new beginning were showing up all over with this vaccine, even if it only helped those who haven't been diagnosed

David Oshinsky's 2005 Polio: An American Story, is a history of the fight to eradicate polio in the 20th century. Polio became one of the most, if not THE most, feared diseases of the century due to the influence and example of President Franklin Roosevelt, who was stricken with the disease as an adult in 1921. Owner of a Warm Springs, GA resort dedicated to polio rehabilitation(where he died in 1945), Roosevelt needed to raise funds to keep the resort operational. In 1934, he allowed planners to throw a nationwide series of birthday parties (over 6,000) for him to raise money for the care of polio survivors and for the upkeep of Warm Springs. The success of these parties and recognition that the key to raising money during the Great Depression

When hygienic conditions were poor polio attacked infants. The disease was spread by contaminated water and contact with fecal contamination. Many infants died when the conditions were poor. But as conditions improved the virus spread differently. It was spread more through playmates and family members, the contamination came from the

Polio is an infectious disease that has killed and paralyzed many people (Birth of Jonas Salk and the death of polio in India). It has taken the lives of

The similarity between the poliovirus and already solved plant virus’s led to a better understanding of how the poliovirus can regenerate within a host. Although the virus was similar to other plant viruses. The poliovirus was covered with more elaborate loops that are the site of monoclonal antibody escape mutations (Hogle, Chow and 229: 1358-1365Filman, Science). Individual proteins of the virus particle are produced by proteolytic cleavages from a larger precursor, yet the amino and carboxy-termini produced by proteolysis are very distinct. By noting this, Hogle and his team were able to conclude that proteolysis was not just making a lot of proteins from one gene, it is also controlling the timing of assembly (Hogle, Chow and Filman, Science 229: 1358-1365).