Poliomyelitis (shortened to polio) has been around for thousands of years, and there is still no cure, but at the peak of its devastation in the United
States, Dr. Jonas Salk introduced a way to prevent it. Polio attacks the nerve cells and sometimes the central nervous system, causing muscle wasting, paralysis, and even death. The disease, whose symptoms are flu like, stuck mostly children, and in the first half of the 20th century the epidemics of polio were becoming more devastating. Salk, while working at the Virus Research
Lab at the University of Pittsburgh, developed a polio vaccine, and the medical trials to prove its effectiveness and safety are still being analyzed. Fifty years ago the largest medical experiment in
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The use of the dual protocol illustrates both the power and the limitations of randomized clinical trials. The control trials with the placebo were important to define the vaccine as the product of scientific medicine, while the observed trials were done to maintain public support for the vaccine. In 1953, Salk presented his tests of a polio vaccine to the Immunization
Committee, the scientific advisory committee for the NFIP. The test results seemed promising to Basil O'Connor, as the children had shown no ill effects and the levels of polio antibodies in their blood had risen. However, several of the senior virologist on the committee questioned the relation of antibodies to permanent immunity. Despite the virologist's critique, O'Connor believed that his organization owed it to the volunteers and donors to proceed and called for the planning of a major field study. O'Connor, in November of 1953, announced that the field trials would begin in the spring and the observed plan would be used. Within a month, health departments in 38 states had responded, enthusiastic about the prospect of a vaccine. A few state officials however, questioned the impartiality of the evaluation run by the foundation, and not by scientists.
Responding to the criticism O'Connor called an meeting of an advisory group to review the statistical design. When the group convened, it had decided to go strictly with the placebo controlled
Polio an American story is a scholarly readable and informative book which covers the lives of many American eminent scientists who struggled a lot to eradicate polio. This book mainly focuses on the mid twentieth century where the people are very eager to find a vaccine to eradicate polio .This book also covers the entire topics from appearance of polio symptoms to post polio syndrome which shows the valuable thesis done by David M. Oshinsky.
Heather Green Wooten’s The Polio Years in Texas: Battling a Terrifying Unknown chronicles the history of polio in Texas in a very extensive timeline. The book goes all the way back to the beginning of the polio epidemic and essentially progresses to the present. The time in this book certainly exceeds that of, The Captured and Isaac’s Storm. The Captured chronicled a long period of captivity, but did not appear to exceed a decade. Isaac’s Storm traced the initial development of Weather Bureau and covered a great period, but did not exceed that of The Polio Years. Several themes begin to emerge further into the book. Obvious themes included, the support for March of Dimes, impact on families affected by polio, the growth and development of rehabilitation facilities, and more importantly the response to the disease by Texans. Oddly, Wooten discusses the fact that other diseases such as, measles, diphtheria, and tuberculosis took more lives than Polio. However, people feared Polio more than the rest. Wooten attributes polio’s terrifying affect to the uncertainty. Several uncertainties such as, how to prevent it, why did some become crippled, why did some die, and why did it only essentially affected children made polio very terrifying in the 20th century. Texas appeared to have been hit the hardest in comparison to other states. Wooten’s research examined the time during and then after World War II. During this period, Texas saw an immense amount of polio contractions. Per
Poliomyelitis was a highly infectious disease that spread through many Americans in the early 20th century. As a matter of fact, over 3,000 Americans died of the disease each year. Families were overwhelmingly desperate for doctors to find a cure. When one suffered from polio, they generally experienced painful symptoms which included not only fatigue and muscle weakness, but even death. Therefore, when the polio vaccine was introduced by scientist Jonas Salk in 1953, it greatly contributed to Americans in numerous positive ways. Environmentally, the vaccine saved countless young American lives affected by the disease thus decreasing American mortality rates. Socially, the polio vaccine convenienced families who were either directly afflicted
Poliomyelitis (polio) is a disease that attacks the nervous tissue in the spinal cord and the brain stem resulting in paralysis (Document One). Polio is caused by the poliovirus, but it is unknown how this virus is acquired. The virus enters the digestive tract and stays in the intestines for up to eight weeks, and then attacks the lymphatic system, the blood stream and eventually travels to the brain and spine (Document Four). Once it is infected in one’s body, the disease is highly contagious and can be spread through contact of saliva, food, germs, or feces (Document Two). “The poliovirus causes most of its infections in the summer and fall. At one time, summer epidemics of polio were common and greatly feared” (Document Four). This may
When you think of horrid diseases a couple will come to mind. One of the ones that comes to my mind is Polio. Even though this disease is virtually eradicated, it was once rampant. Paralyzing and killing children, there was no treatment or cure for this horrendous disease. As stated by Indiana Jen, “It wasn’t until the 1960s that the Salk vaccine was developed enough to provide immunity to 99% of recipients.” Nowadays, most adults and children never have been touched by the disease and fail to recall that it was once a killer of children.
David Oshinsky's 2005 Polio: An American Story, is a history of the fight to eradicate polio in the 20th century. Polio became one of the most, if not THE most, feared diseases of the century due to the influence and example of President Franklin Roosevelt, who was stricken with the disease as an adult in 1921. Owner of a Warm Springs, GA resort dedicated to polio rehabilitation(where he died in 1945), Roosevelt needed to raise funds to keep the resort operational. In 1934, he allowed planners to throw a nationwide series of birthday parties (over 6,000) for him to raise money for the care of polio survivors and for the upkeep of Warm Springs. The success of these parties and recognition that the key to raising money during the Great Depression
Polio is a deadly virus that hit america in the 1930s (Franklin Roosevelt founds...N.P.). Franklin Roosevelt founds March of Dimes Polio is also known to be a crippling disease, which affected Franklin Delano Roosevelt at the age of 39. But, on January the third he created a foundation for a cure for polio called March of Dimes(Franklin Roosevelt founds March of Dimes N.P.).10 years later he created a foundation,Warm Springs Foundation, which focus entirely on the treatment of people with polio(Franklin Roosevelt founds March of Dimes N.P.). In 1934, a business, Henry Doherty donated $25,000 to establish a series of birthday balls(Franklin Roosevelt founds March of Dimes N.P.). In the first year they raised 1 million dollars off
Childhood vaccinations is a part of life that some people are not willing to accept. Especially the MMR vaccine, which stands for measles, mumps, and rubella. There seems to be a lot of attention that comes along with this specific vaccine because some people believe that there is a link between the MMR vaccine and autism. Even with these concerns parents should still have their children vaccinated because they could be saving the lives of their children and the lives of their loved ones.
Introduction: Public health achievements in the areas of vaccinations to prevent disease, disease prevention and control, laws to limit the consumption of tobacco, maternal and infant health, and cardiovascular disease are achievements on their own. With public health, improvements in one area often have an effect on a different area of public health. Improvements in vaccinations, for example, will improve maternal and infant health as a reduced number of mothers and infants will fall ill from diseases preventable by vaccination. In addition, vaccinations control the spread of infectious disease, and reduce the incidence rate of the disease in a population.
Attended the Yalta Conference with Winston Churchill to express ideas about alterations after the war in 1945.
When hygienic conditions were poor polio attacked infants. The disease was spread by contaminated water and contact with fecal contamination. Many infants died when the conditions were poor. But as conditions improved the virus spread differently. It was spread more through playmates and family members, the contamination came from the
Polio is an infectious disease that has killed and paralyzed many people (Birth of Jonas Salk and the death of polio in India). It has taken the lives of
When children are born and for the first two years of their lives, they receive multiple shots and drops of vaccines. These vaccines protect them from getting diseases that were deadly and common in children many decades ago. Vaccine is one of the greatest achievement in medicine history. There were thousands of lives lost in the battle with some of the terrifying diseases like smallpox and polio. Now, after years of vaccine invention, vaccination spread in many countries which helped in eradicate several illnesses. In the United States, each family is required to show their children's immunization chart in order to get accepted in many educational institutes. Parents usually face the decision whether to vaccinate
The similarity between the poliovirus and already solved plant virus’s led to a better understanding of how the poliovirus can regenerate within a host. Although the virus was similar to other plant viruses. The poliovirus was covered with more elaborate loops that are the site of monoclonal antibody escape mutations (Hogle, Chow and 229: 1358-1365Filman, Science). Individual proteins of the virus particle are produced by proteolytic cleavages from a larger precursor, yet the amino and carboxy-termini produced by proteolysis are very distinct. By noting this, Hogle and his team were able to conclude that proteolysis was not just making a lot of proteins from one gene, it is also controlling the timing of assembly (Hogle, Chow and Filman, Science 229: 1358-1365).
During the 20th century, the infectious disease death rate decreased from 800/1000 deaths to less than 100/1000 deaths. This is mainly due to the introduction of immunisation. Vaccination has clearly prevented millions of deaths over the last century; nevertheless, the anti-vaccination movement has grown significantly in recent years. Some of the reasons why people join this movement include the belief that vaccines don’t actually work, the belief that vaccines are unnatural and therefore unhealthy and the belief that vaccines contain toxins that cause bodily damage and neuropsychiatric problems (eg. Autism). This essay will discredit the beliefs associated with the anti vaccination movement through infectious disease statistics,