Polycystic Ovary Syndrome (PCOS), diabetes mellitus, hyperprolactinemia, luteal phase defects, as well as thyroid antibodies and disease are regularly encountered endocrine factors that establish a hormonal link between RPL and infertility. Although the exact pathophysiology underlying these disorders in relation to RPL and infertility is unclear, commonly accepted mechanisms of action have been suggested.
Diabetes mellitus
There are two types of diabetes mellitus: Type 1 diabetes (T1D) and Type 2 diabetes (T2D). T1D is characterized by the inability to produce adequate insulin. T2D, which is more prevalent, is characterized by insulin resistance primarily due to fatty diets and sedentary lifestyles72,73. Sufficient insulin production and/or supplementation is vital to maintaining a healthy female
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It affects 5-10% of women of reproductive age77,78The Rotterdam Criteria are most commonly used to diagnose PCOS. At least two of the following three criteria must be present before a diagnosis can be made: oligo/anovulation, hyperandrogenism, and the presence of polycystic ovaries.
Women with PCOS exhibit high LH levels and thereby have elevated production of androgens by theca cells. Hyperandrogenism can, in turn, suppress FSH production, leading to ovarian dysfunction, anovulation and infertility. The prevalence of PCOS in women with RPL runs as high as 56% 79,80,81. Obesity coupled with high LH levels can hinder ovarian folliculogenesis and increase the risk of miscarriage. Studies have also suggested an association among PCOS and hyperinsulinemia/insulin resistance, obesity, and hyperhomocysteinemia. Hyperinsulinemia and insulin resistance can negatively affect implantation by decreasing activity of cell adhesion proteins. Hyperhomocysteinemia can also result in miscarriage because of its pro-coagulative nature, similar to cases of thrombophilia
Hyperandrogenism often presents itself in the physical form with acne, hirsutism (male-patterned hair growth), and alopecia. While insulin resistance is typically present in a patient with a higher BMI, 70% of women with PCOS have this condition, putting them at a higher risk of developing Type 2 diabetes (Goodarzi et al., 2011). Other metabolic complications can occur with PCOS, including hypertension and dyslipidemia (Madnani, 2013). The hormonal secretions of the body’s endocrine glands are affected by the hormonal secretions of the ovaries and vice versa via feedback mechanisms. The disruption of normal hormone secretions, particularly hypersecretion of luteinizing hormone (LH), can reduce the chance of conception and increase the risk of miscarriage (Balen,
Polycystic Ovary Syndrome is a common endocrine disorder that can affect many women. It is also “an incurable disorder that affects 1 in 10 women and over 50% do not know they have it” (PCOS Awareness Association, 2014). An ultrasound exam can reveal that women with PCOS have a collection of follicles on enlarged ovaries. The particular cause of polycystic ovary syndrome is unknown. It could be connected to long-term complications; therefore, doctors recommend weight loss to reduce this risk. Also, early diagnosis and treatment can have an impact on deciphering if a woman will have long-term complications. Such complications include type 2
The motive of this paper is to present a analysis of current research on polycystic ovary syndrome more commonly known as PCOS. Pcos is one the most common endocrine disorders in women of reproductive age, affecting 5-10% of the population. Despite it's prevalence, pcos remains largely unknown. The main focus of this paper will be explaining what PCOS is, the causes, the diagnosis and the treatment of polycystic ovary syndrome.
Polycystic ovarian syndrome (PCOS) is a heterogeneous collection of signs and symptoms that together for a spectrum disorder with a mild presentation in some but a severe in others. The pathophysiology of PCOS appears to be multifactorial and polygenic. (Fox, 2011)
According to PubMed Health, Polycystic Ovary Syndrome (PCOS) is a condition in which women possess abnormally high level of male hormones. The high hormone levels lead to risks of irregular or absent menstrual cycles, insulin resistance, ovarian cysts, issues related to the circulatory system, obesity, heart disease, diabetes and etc. Symptoms differ between each woman therefore, despite research data collected showing that PCOS affects 5-10% of women between the age of 18-44, there are many women who live their lives unaware that they have PCOS. The most common symptoms include: absences of ovulation, high levels of androgen present, and abnormal hair growth. The cause of PCOS is still unknown as more research is much-needed to better understand the disorder.
One study done on one hundred patients with PCOS showed that administration of metformin and pioglitazone shows 50 percent effectiveness in helping menstrual cycle irregularities by the end of six-months of treatment. Both medications also showed a decrease in LDL and an increase in HDL overall, but this was seen more in the pioglitazone group. This study showed that 64% of women with PCOS also had hyperinsulinism. HOMA-IR, used to assess insulin resistance, was shown to have a 15% decrease with metformin and a 50% decrease in patients who used pioglitazone. Thus, for protection from diabetes pioglitazone may be the better treatment. Ovulation was shown to be restored in up to 56% of patients on metformin and pioglitazone. This study showed that pioglitazone may be a new and better option for treatment of PCOS since it can delay onset of type II diabetes, help with signs of hyperandrogenism, and regulate menstrual cycles (sangeeta,
Polycystic Ovarian Syndrome also known as Stein-Leventhal Syndrome, occurs in 5% to 10% of women and is one of the causes of infertility. PCOS is observed by ultrasound as a number of small cysts on a woman’s ovary, and it’s
Since PCOS is the most common endocrine disorder for women of reproductive ages, Questions to explore are: How does lifestyle factors such as obesity impacts the development of PCOS, how does PCOS affects a women quality of life and what are the best treatment options?
Polycystic ovary syndrome (PCOS) affects approximately seven to eight percent of women of childbearing age. While the cause of PCOS is still unknown, it is believed to be a genetic disorder. Often a mother or sister of a woman affected will exhibit symptoms similar to PCOS. Due to the change in the levels of estrogen and progesterone, during ovulation mature eggs are not released which begin to form very small cyst within or on the ovary. These cysts cause infertility. Women suffering from polycystic ovary syndrome can overcome infertility through weight loss, laparoscopy (ovarian drilling), medicinal treatment or in vitro fertilization (IVF).
For this article there were no research questions, but the authors wanted to focus on the pathogenesis, diagnosis and treatment of PCOS. They found that polycystic ovary syndrome (PCOS) is common in women, with a10% prevalence in women of reproductive age. Polycystic ovary syndrome is defined as ovarian dysfunction with polycystic ovaries. It also includes androgen excess which is shown by testosterone levels being elevated. Increased levels of testosterone can be seen through excess body hair. Obesity is seen in many women with PCOS, this can lead to insulin resistance and Type II Diabetes. Genetics has an impact on polycystic ovary syndrome with 20-40% of people with PCOS having first-degree relatives with the syndrome.
Polycystic ovary syndrome is an endocrine disorder that affects at least 10% of women living in the United States. Insulin Resistance plays a large part in fertility for women who have polycystic ovary syndrome. Myo-Inositol improves fertility, and alleviates many of the symptoms associated with polycystic ovary syndrome and insulin resistance.
Polycystic ovary syndrome (PCOS) is one of the most common hormonal endocrine disorders in women. This syndrome includes multiple cysts in your ovaries that are filled with fluid. It can be easily seen on an ultrasound when there is a string of pearls(cysts) on your ovaries. Many women experience infrequent periods, weight gain, elevated hormone levels and type 2 diabetes.
Polycystic Ovarian Syndrome occurs when the ovaries produce more androgen hormones or male hormones than progesterone hormones or the female hormones. When there is a high level of the androgen hormone this decreases the release of the eggs during regular ovulation, causing the infertility as well as some of the common signs of Polycystic Ovarian Syndrome, that is infertility or the inability to get pregnant, in which PCOS is actually the leading cause to women with infertility, acne, Hirsutism which is the increase of body hair in specific parts of the body, and weight gain or
There is one dream that every little girl has when growing up, that is becoming a mother; to love and watch her children grow. No one ever dreams of that not happening to them or being part of that group being label as infertile. It happens to millions of women living in the United States every day. Polycystic Ovary Syndrome is the most common endocrine disease that affects women of reproductive age, which is typically puberty to menopause. Polycystic Ovary Syndrome does not only affect a woman’s ovaries and chances of conceiving, but it affects the whole endocrine system in the body. It can cause Excess Androgen Production, Insulin Resistant, Obesity, Hirsute and Cardiovascular problems.
Oxidative stress can also be present in non-obese PCOS patients. Cardiovascular disease is increased by PCOS, therapies for this particular symptom could include the use of antioxidants as a corrective measure, to improve the effects of oxidative stress by reducing insulin resistance and hyperandrogenism (Deasaiet al, 2014).