Article Report
Brent Henrikson
Name: University
Article 1
Abstract
“Pre-exposure prophylaxis (PrEP) for HIV prevention is a promising experimental approach currently being tested globally. A number of PrEP trials are evaluating the safety and effectiveness of PrEP in men who have sex with men (MSM) and other populations at risk for HIV, and results will be available from this first generation of efficacy trials over the next few years. Here we review the rationale for orally-administered antiretrovirals for prevention, and outline issues the first generation trials will address as well as questions that may be addressed in future studies. We also describe the rationale for combination prevention approaches that may combine PrEP with other prevention modalities as part of a larger prevention package” (Buchbinder and Liu, 2011).
Summary
Buchbinder and Liu (2011) underscored the importance of pre-exposure prophylaxis (PrEP) by stating that the future prevention and management of HIV infection lies in the ability to prevent the infection in the first place. This article focused on “reviewing the rationale for orally-administered antiretrovirals for prevention, and outline issues the first generation trials will address as well as questions that may be addressed in future studies” (Buchbinder and Liu, 2011). The article also focused on discussing the reasoning for combining PrEP with other prevention methods. A number of trials have been focusing on determining
HIV and AIDS have had a great impacted throughout varies countries. As an illness with no none cure, it is essential to promote prevention among those at risk. Thailand’s “No Condom, NO sex: The 100% Condom program” was successful at greatly reducing the cases of new HIV infection cases (Levine, 2007, p.10). Thailand’s program has the advantage to serve as a building block to many other countries experiencing high levels of HIV/AIDS infection, but is limited due to
In Pennsylvania, a plaintiff claiming negligent infliction of emotional distress must establish one of these four situations: “1) that the defendant had a contractual or fiduciary duty; 2) plaintiff suffered a physical impact; 3) plaintiff was in a “zone of danger” and at risk of an immediate physical injury; or 4) plaintiff had a contemporaneous perception of tortious injury to a close relative.” Doe v. Phila. Cmty. Health Alternatives AIDS Task Force, 754 A.2d 25, 27 (Pa. Super. Ct. 2000). The first element does not apply to our client because there was no fiduciary or contractual duty relationship. Secondly, it could be argued that Nordlund suffered a physical impact because after Sumner’s accident, Nordlund could not eat, could not
According to recent statistics from the Centers for Disease Control, approximately 1.2 million individuals in the United States have HIV (about 14 percent of which are unaware of their infection and another 1.1 million have progressed to AIDS. Over the past decade, the number of HIV cases in the US has increased, however, the annual number of cases remains stable at about 50, 000 new cases per year. Within these estimates, certain groups tend to carry the burden of these disease, particularly the gay, bisexual, and men who have sex with men (MSM) and among race/ethnic groups, Blacks/African American males remain disproportionately affected. (CDC)
(2011) was a multi-continent, randomized, controlled trial to evaluate the effectiveness of antiretroviral therapy on the speed of the disease process among HIV-1 infected and HIV-1 uninfected partners. In the study, 1,763 HIV mixed status couples were grouped into either early antiretroviral and delayed therapy groups. Inclusion criteria consisted of the HIV-1 infected participant having a CD4 count between 350 and 550 with no previous antiretroviral therapy usage, except to prevent mother-baby transmission. Participants attended three monthly sessions and then quarterly sessions until ill or requiring an additional amount of antiretroviral drugs (Cohen et al, 2011). The uninfected partners were tested each quarter for seroconversion, the period in time in which antibodies become detectable. The research study concluded that early antiretroviral therapy initiation had a greater effect on CD4 count than delayed antiretroviral therapy. The average CD4 count in the early therapy group originated at 400 and increased to 603 after 12 months of ART. A decline of CD4 cells were noted in the delayed group (Cohen et al, 2011). The authors concluded that a higher incidence of HIV transmission was noted in African countries and adverse effects were more likely to occur in the early therapy group. Early therapy had a positive effect on the HIV-1 uninfected and HIV-1 infected
The implementation of HIV prevention strategies such as Pre-exposure prophylaxis (PrEP) is a method in which individuals who practice risky behavior take a pill that will prevent them from becoming infected with HIV. Storytelling and new media activities is used to spark the interest of this population. “For example, Keep it Up! an interactive online program focused on healthy sexuality, relationships, and preventing HIV was recently found to be feasible and acceptable among diverse YMSM” (Macapagal, Birkett, Janulis, Garofalo, & Mustunski, 2017). Subsequently, there was an increase of condom use by the young men who participated in this program. The intervention program called Popular Opinion Leader (POL) focuses on training individuals such as the young African American (MSM) to encourage members of his community to practice safer and healthier sexual behavior
Although, (NIH, 2007) reports that condoms have reduce HIV Transmission by 87-95 percent. To get these African American male students from seeing it to exploring condom use as an option or a benefit is contemplation. However, a Condom Education Program is placed an inner city high school, whose population is 65 percent Afro-American male. NIH reported data is the goal of the program. The objective is by the end of the year, 45% of Afro American sexual active males are
PrEP works by blocking important routes that HIV uses to spread its infection. If taken as prescribed, the medicine flowing through the bloodstream should inhibit HIV from spreading through the body. However, when not taken daily, the result may be too little medicine in the bloodstream to stop the spread of HIV. When taken as prescribed, PrEP has been understood to lessen the risk of HIV by more than 90% in people who are at a high risk. PrEP can even be more effective and preventative of HIV when it is combined with other methods. The combination of condom use and drug abuse treatment can be even more of a HIV deterrent when combined with PrEP.PrEPis effective in treating people who are HIV-negative and very prone to the
Prevention of HIV begins with using latex condoms during sex. In addition to using condoms, abstinence, limiting the number of sexual partners, and not sharing needles are
Human immunodeficiency virus (HIV)/AIDS is a pandemic problem affecting global health. At the end of 2015, 36.7 million people were living with HIV/AIDS globally. The rate of incidence is more prevalent in Sub-Saharan Africa with almost 1 in every 24 adults living with HIV/AIDS. In the united states, HIV/AIDS is a diversified health problem affecting all sexes, ages and races and involving the transmission of multiple risk behavior. However, with the introduction of various prevention programs and antiretroviral drugs, the incidence of HIV/AIDS has reduced.
I understand where you are coming from, but the science has advanced so much since then. First, the only safe sex and no sex. Condoms are highly effective in preventing infection, but it is also not fail proof. Second, I think PrEP must be looked in the context of harm reduction. According to the Centers for Disease Control and Prevention, there are almost 50,000 people who contract HIV a year. They also estimate that there are about 1.2 million people in the U.S. living with HIV/ADS and of those, about 14% do not know they are infected. PrEP presents a very real chance we could halt the epidemic in our
Just as there are risk factors, there are many ways to decrease that risk. Proper condom use decreases the risk of HIV infection by 98-99% and using a medication called pre-exposure prophylaxis, or PrEP, before sexual contact can reduce the risk by 92-99%. (“Love”) Knowing the HIV status of an individual’s partner or partners can also greatly reduce the change of HIV transmission. After all, the only way to become infected with HIV is to come into contact with a person who is HIV positive.
Pre-exposure prophylaxis (PrEP) use has proven to be efficacious in clinical study settings for the prevention of HIV infection; however, more knowledge is needed to inform best practice models for implementation of PrEP in high-risk urban populations. In upcoming years, we can expect many AIDS service organizations (ASOs) and community-based organizations (CBOs) to integrate PrEP into their clinics as a prevention tool. Demonstration projects are underway all over the country to study the implementation of PrEP, yet many of them do not consider the need for comprehensive sexual health services, including regular STI screening and treatment, post-exposure prophylaxis (PEP), and access to primary care for high risk youth. The
Pre-exposure prophylaxis (PreP) is a preventive measure against HIV for people that have a high risk of contracting the virus, not for people with the virus. In order to reduce the likelihood of catching HIV, PreP consists of taking the medication pill, Truvada, on a daily basis. Think of it as a birth control pill, in the sense of, if you miss a day the chances of getting pregnant are increased. Same goes with taking Truvada, effectiveness will definitely decrease if the medication isn’t taken on a strict daily regimen.
“A further 20% believed that their chances of picking up an infection were next to nothing in these circumstances. A quarter of the people surveyed, said they did not use contraception as they trusted the person they were sleeping with not to have an STI, while one in ten reported they did not like the feeling of condoms. Sexual orientation can also influence an individual’s sexual health”. It was also noted that men who have sex with men have relatively high rates of HIV, and that women who have sex with women have sexual health needs that are not being met that can lead to riskier sexual
In the last three decades HIV/ AIDS has become the one of the most notorious and widely spread diseases in the modern world. Its discovery in the late seventies prompted worldwide concern. The one thing that has become the most bothersome thing about the HIV/ AIDS epidemic is prevention. Prevention or stopping the transmission of the diseases is hindered by factors such as: denial or non-acceptance by infected persons, unsafe sex, and non-disclosure by infected persons to their at risk sexual partner(s). According to Alghazo, Upton, and Cioe (2011):