Reaction Paper On Salmonella Typhi

1034 Words5 Pages
Abstract The Salmonella typhi shows the resistance against several antibiotics in different regions of the world. The pattern of resistance is also variable worldwide. The antibiotic resistant character of the S. typhi is due to the production of several enzymes against antibiotics and mutations in genes. DNA gyrase A, active efflux, and plasmid mediated resistance patterns are involved in the resistance against antibiotics like ampicillin, quinolones, chloramphenicol, tetracyclins, co-trimoxazole, ciprofloxacin and in few strains cefitriaxone. Several lactamases, reductases and acyltransferases are major contributor of the resistance patterns.
Introduction
Salmonella enterica subspecies enterica serotype typhi is genetically the monomorphic, restrict human pathogenic bacteria (Gevers D. et al., 2005). Typhi enters in few individuals as the carrier and shed high level of bacteria without any symptoms. It is believed that typhi was first evolved in Indonesia that have flagellar antigen (Mortimer et al., 1999; Frankel et al., 1989). The fever caused by Salmonella enterica is a major health problem and resulted by the poor hygiene conditions. The enteric infection is worldwide and occurs in both developing and developed countries. It is
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typhi. The transfer of ACCoT-resistance of S. typhi isolates has been reported earlier from different parts of India. It has been reported that about 120 kb plasmid encodes resistance to A, C, T, and streptomycin in S. typhi isolates from Kolkata (1989-1990). This result, the investigation of R-plasmid contained in strains of S. typhi. AGE (Agarose Gel Electrophoresis) analysis elaborated the presence of a single plasmid that is of approximately 55 kb among the isolates. Thus present findings suggest that MDR S. typhi may arise from sensitive isolates by acquisition of multidrug resistance plasmid from antibiotic-resistant enteric
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