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Research Paper On Poliomyelitis

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The word poliomyelitis is derived from two Greek words, polio meaning grey and myelon meaning marrow which indicates the spinal cord. The classic manifestation of paralysis is the effect of polio virus on the spine (Paul, 1971). Ancient records mention crippling diseases compatible with poliomyelitis. A weakness of the lower limbs in children that was identifiable as poliomyelitis was first described by Michael Underwood in 1789. The first outbreaks were reported in the early 19th century and in 1843 in Europe and the United States respectively. For the next century, polio epidemics were reported from developed countries in the Northern Hemisphere each summer and fall. As years passed, the severity of the epidemics and the average age of persons affected increased (Birmingham et al.,1997). This led to an increase in the number of deaths as a resulting from polio. Polio cases hit a peak in the USA in 1952, where more than 21,000 paralytic cases were reported (Paul, 1971). However, polio incidence declined rapidly following introduction of …show more content…

The virus is a member of the enterovirus sub-group, family Picornaviridae. Enteroviruses are transient inhabitants of the gastrointestinal tract, and are stable at acid pH. Picornaviruses are small, ether-insensitive viruses with an RNA genome (Musa et al., 2009). It is shed in large quantities in the throat and intestines of infected persons such that a mere gram of stool may contain several million virus particle (Saunders et al., 2011). Poliovirus exists in three serotypes (P1, P2, and P3) (Dowdle & Birmingham, 1997). There is marginal heterotypic immunity between the three serotypes such that immunity to one serotype does not produce substantial immunity to the other serotypes. The poliovirus is quickly inactivated by formaldehyde, chlorine, ultraviolet light, and heat (Paul,

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