Introduction:
Asthma is a “chronic inflammatory disease of the airways” and causes difficulties in breathing due to the widespread narrowing of the bronchial airways1. Asthma can occur in people of all ages and affects approximately 10.2% of Australians (2011-12) 2. Generally asthma is reversible with or without treatment however over time damage may occur3. Therefore it is important for patients to manage their asthma well in order to maintain a healthy and quality lifestyle. One of the most effective treatments used to control asthma is Salbutamol. Salbutamol is a short acting B2 adrenergic agonist and it is mainly used for quick relief or to prevent the onset of asthma3. This essay will explain the physiology of the respiratory system and the effect on the system when a person has asthma. It will also discuss the use of salbutamol as a treatment for asthma.
Normal Physiology of the Respiratory system.
The lungs are the main organs in the respiratory system and they facilitate the exchange of oxygen and carbon dioxide when a person breaths.
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When this drug is inhaled or taken, it binds to the B2 adrenergic receptor which are “coupled to stimulatory G protein Gs” 3, 15, 16. The Gs protein is comprised of an alpha, beta and omega subunit 17. The activation of adenyl cyclase is caused by the alpha Gs, which catalyses the synthesis of cyclic AMP. As a result there is an increase in the intracellular concentration of cyclic AMP and protein Kinase A is activated 3,10. The protein Kinase A regulates the activity of an enzyme called myosin light chain phosphorylase. Decreased activation of myosin light chain phosporylase leads to relaxation of smooth muscles. The B2 adrenergic agonist also decreases Ca2+ intracellular concentration and it contributes to muscle relaxation3,16. Ultimately it leads to bronchodilation and allows enough oxygen to flow to the alveolar
Albuterol has affinity to β 2 receptors and binds to them, causing a relaxation effect. β2 receptors are members of the adrenergic family of receptors and therefore its effects are caused by an interaction with G proteins. β
Answer) Like “Albuterol Sulfate”, Accolate is a bronchodilator which helps open the bronchi and bronchioles of the airways in the lungs. Accolate affects the leukotrienes in the lungs. Leukotrienes cause the lining of the breathing passages in the lungs to become inflamed. When an asthmatic takes Accolate, the medicine does not allow the leukotriene chemical reaction to occur, therefore the bronchi and the bronchioles of the lungs do not become constricted, and the patient can breathe without symptoms of asthma.
The primary function of the respiratory system is the exchange of gases. The respiratory system allows oxygen and carbon dioxide exchange, this is necessary to sustain life. During the process of breathing air is inhaled and carbon dioxide is exhaled, this change of gases occurs in the alveoli. The inhaled oxygen passes into the alveoli and then diffuses into arterial blood. The waste rich blood from the veins releases carbon dioxide into the alveoli which is
The respiratory system is made up of organs and tissues that help you breathe. The main parts of this system are the lungs, the trachea, the diaphragm, alveoli and nasal cavity. The respiratory system starts with the mouth and the nose, where air is brought in, then passes through the larynx and the trachea into the chest cavity. http://www.nhlbi.nih.gov/health/ health-topics/topics/hlw/system The main organs of the respiratory system are lungs, which carry out this exchange of gases as we breathe. The
The respiratory system is a complex organ structure of the human body anatomy, and the primary purpose of this system is to supply the blood with oxygen in order for the blood vessels to carry the precious gaseous element to all parts of the body to accomplish cell respiration. The respiratory system completes this important function of breathing throughout inspiration. In the breathing process inhaling oxygen is essential for cells to metabolize nutrients and carry out some other tasks, but it must occur simultaneously with exhaling when the carbon dioxide is excreted, this exchange of gases is the respiratory system's means of getting oxygen to the blood (McGowan, Jefferies & Turley, 2004).
The Respiratory system is an integrated system of organs involved in the intake and exchange of oxygen and carbon dioxide between an organism and the environment. Your Respiratory system is made up of the organs in your body that help you breathe. The Respiratory system is the system of the body that deals with breathing. The trachea is a wind pipe. The trachea is a pipe shaped by rings of cartillage. A Bronchi are two tubes that carry air into the lungs. The Respiratory system consistes of many different organs. The organs are the lungs, trachea, bronchi, alveoli, diaphragm, nose, mouth, and pharynx. In the Respiratory system the right lung is larger and has more lobes that the left lung becuase the heart is normally located on the left side, and takes up space where the lung would had been. The functions of the Respiratory system is to supply the blood with oxygen in order for the blood to deliver oxygen to all parts of the body. The Respiratory system is also used for the of exchange gases. The importance of the Respiratory system is that it allows for the exchange of gases; meaning carbon dioxide and oxygen. These gas exchanges occur in the alveoli's and the capillaries. This gas exchange of gases is the Respiratory system's means of getting oxygen to the blood. The goal of breathing is to
Fluticasone propionate is a synthetic triflourinated corticosteroid that possess anti-inflammatory properties (RxList). This corticosteroid targets cells and mediators involved in inflammation, having an anti-inflammatory effect on the airways (RxList). Salmeterol Xinafoate is a long acting- beta agonist (LABA), targets the beta2-adrenoceptors that are present in the smooth muscle of the bronchioles (RxList). By targeting the beta2-adrenoceptors, intracellular adenyl cyclase is stimulated, which will lead to the production of more cyclic AMP. An increased level of cyclic AMP then leads to relaxation of the smooth muscle of bronchioles
The bronchi and bronchiole tubes are loosely wrapped with muscle. During regular breathing, the muscles around these airways are relaxed (5). This allows air to flow freely through these passageways to the alveoli. However, during an asthma attack, air has trouble reaching the alveoli, which prevents the body from receiving oxygen. This is because the airways become smaller. Firstly, the muscles around the airways spasm and contract. This then causes inflammation of the bronchioles and bronchi themselves, which causes a mucus to be produced.
Albuterol also known as Salbutamol is a common medication used to treat asthma and similar respiratory ailments.[1] Albuterol is a bronchodilator and works to open the airways of the lungs. Albuterol can be taken intravenously or orally. The preferred method of this substance is orally, which in itself have various ways of being administered. One way is by inhalation, either from a vapor mist in the form of an inhaler and a nebulizer or, as a powder like Advair. In addition to inhalation, albuterol can be ingested as syrup or a tablet. Because of it varying forms Albuterol is can easily meet the need of the patient, making it a popular medication to treat asthma, emphazma, bronchitis and other airway constricting disorders.
1) The bronchioles of the respiratory system contain the beta 2 receptors, Salbutamol is a beta-2 adrenoceptor agonist capable of binding to beta-2 receptors. Once the drug binds to the beta-2 receptors, the receptors result in conformational change and deforms. Also, Binding to the receptors start to activate the G-Protein in order to convert GDP to GTP. As the result of this, the Alpha part of the G-proteins become separated from gamma-beta subunits and freely distribute into the membrane binding to Adenyl Cyclase leading to the conversion of CAMP from Adenosine triphosphate (ATP). Kinase A which is located inside the cell is activated by the CAMP. Activation of Kinase A promote to inactivate the phosphorylation of the myosin enzyme causing
Ventolin is a name brand, prescription medication that is prevalent among asthmatics. Its molecular structure is referred to as salbutamol and is sold with both enantiomers of the molecule in a racemic mixture. Ventolin is used to treat asthma, exercise-induced bronchospasms and even help with chronic obstructive pulmonary disorders (COPDs). This medication can be administered or taken with an inhaler, nebulizer, pill or even an intravenous solution. In order for this medication to take effect and induce bronchodilation, it must undergo a series of steps. For the purpose of exhibiting the use of Ventolin, we will analyze its use via inhaler, on a person having an asthma attack.
Airway hyperresponsiveness or bronchial hyperreactivity in asthma is an exaggerated response to numerous exogenous and endogenous stimuli. The mechanisms involved consist of direct stimulation of airway smooth muscle and indirect stimulation by pharmacologically active substances from mediator-secreting cells such as mast cells or nonmyelinated sensory neurons. The degree of airway hyperresponsiveness generally correlates with the clinical severity of
The main function of the lungs is to allow gas exchange, where oxygen is inspired from the air and carbon dioxide is expired. There are two lungs in the body, a left lung and a right lung. These lungs are made up of many small sacs known as alveoli, which is
This concept is taken from Block 4, Module 6 which is entitled as ‘Assessment of respiratory system’. The respiratory system comprises of different organs used in respiration. Respiration involves inhalation and exchange of oxygen and carbondioxide between living organisms and the environment. The organs of respiration include; the nose, pharynx, larynx, trachea, 2 bronchi, bronchioles, 2 lungs and muscles of breathing (the intercostal muscles and the diaphragm).
The lungs function as an important part of the respiratory system. We, humans, have two lungs. Surprisingly, the two lungs have some differences; the right lung is slightly larger than the left lung because the left lung must leave space for the heart, and the right lung has three lobes while the left only has two. The lungs house the alveoli and the capillaries, which exchange oxygen (O) from the air that we breathe in with carbon dioxide (CO2) that has been released into the bloodstream by cells in the body. The diaphragm, a muscle which is located below the lungs, is what helps the lungs contract and expand.