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Salbutamol Case Study

Decent Essays

I would explain to Sarah’s mother that although there is no solid evidence demonstrate that tolerance may develop to the bronchodilator effects of Salbutamol [3], there are many studies supported that regular use of β2 agonists include Salbutamol lead to tolerance to their bronchodilator effects. [1][2][4][5][6] The main hypothesis of tolerance from regular use of salbutamol is associated with desensitisation of β2 adrenoceptor on the airway smooth muscle. [1][4][6] It is a protective mechanism to prevent overstimulation of receptors as a result of continuous salbutamol exposure. Desensitization consist of 2 main processes which are uncoupling of the receptors from adenylate cyclase and internalisation of uncoupled receptors. [1][4][6] Exposure

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