Sickle-Cell Research Papers

Now that the disease is more clearly defined, we must ask, why did this illness come about? This is one of the most interesting facts about Sickle Cell. Since the trait originated in countries that were ravaged by malaria, it could be said that this trait evolved to fight the deadly mosquito-spread disease. "People with sickle trait were more likely to survive malaria outbreaks in Africa than those with normal hemoglobin, it is

The frequency of the sickle-cell allele in populations provide a good example of adaptation on a genetic level. Is from what the person inherits from both parents if the parents carry the gene. When it comes to demographics/culture Sickle-cell allele is commonly found in American Americans people. With geography location and climate has had a big impact on where the disease is commonly found. Mutations inherently are fairly neutral because it is different for each person. For instance, in the video “Malaria and Sickle Cell Anemia” the two sibling at the beginning of the video both had Sickle Cell. Sky life, health wise is a lot better than her younger brother who had to have surgery

Hypothesis: African-American parents with the Sickle Cell Trait have the greatest risk of passing Sickle Cell Anemia to their offspring.

The sickle cell disease affects about 100,000 people in the America. The most common ethnic group the sickle cell anemia is seen in is African Americans and Hispanics. Approximately one in every ten African American and one in every one hundred Hispanic Americans have the sickle cell trait. Approximately two million people have the sickle cell trait in America. Approximately one in five- hundred African Americans and one in one thousand to one thousand and four hundred Hispanic-Americans have sickle cell disease. No universal cure has been found for sickle cell anemia (“Facts About Sickle Cell Trait And Disease,”n.d.). Sickle cell anemia affects many Americans and a universal cure needs to be found.

Approximately 100,000 people suffer from Sickle Cell Anemia everyday and about 2 million people have the Sickle Cell trait in the United States alone. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Pruthi 2018). The disease is estimated to occur in 1 in 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans (Pruthi 2018). Sickle cell anemia is an inherited form of anemia, a condition in which there aren't enough healthy red blood cells to carry adequate oxygen throughout your body normally, your red blood cells are flexible and round, moving easily through your blood vessels. In sickle cell anemia, the red blood cells become

Sickle Cell Disease is normally viewed as a “black” disease, yet the primary areas of geographic origin of the disease are the Mediterranean Basin and Central Africa, regions that are primarily “white”.

Sickle cell disease affects millions of people worldwide. It is most common among people whose ancestors come from Africa; Mediterranean countries such as Greece, Turkey, and Italy; the Arabian Peninsula; India; and Spanish-speaking regions in South America, Central America, and parts of the Caribbean. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans. The disease is estimated to occur in 1 in 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans.

The probability of inheriting a disease is not random. There are several factors that determine the chances on inheriting a disease such as race, gender, genetics, etc. A person of Caucasian decent is more likely to develop cystic fibrosis, an Asian person has a higher chance of inheriting Kawasaki disease and there is a very high rate of Sickle Cell Anemia among people of African lineage. Sickle Cell disease is inherited and it affects the anatomy of the red blood cells, resulting in a sickle shape which then affects the functions of red blood cells causing a blood disorder. Sickle Cell is a recessive disease and persons affected have both copies of the hemoglobin S gene. This genetic defect causes red blood cells to become sickle-shaped (cresent shape). The abnormal shape severely impede the ability of red blood cells to pass through small blood vessels. This impediment caused by the sickle-shaped red blood cells decreases the flow of blood to parts of the body. This reduced blood flow to tissues causes hypoxia and subsequently leads to tissue damage. This alteration in the function of red blood cells is what leads to the complications of sickle cell disease. There are various types of sickle cell disease. The most common types of sickle cell disease are Sickle Cell Anemia (SS), Sickle-Hemoglobin C Disease (SC), Sickle Beta-Plus Thalassemia and Sickle Beta-Zero Thalassemia. Often conflated with sickle cell disease is "Sickle Cell Trait". Sickle cell trait means that a

Sickle cell disease is a hereditary blood disorder caused by an abnormal hemoglobin in the red blood cell. Hemoglobin is a type of protein that carries oxygen in the body. In order for someone to have sickle cell disease they would need to have been passed down from at each one of their parents, by inheriting a total of two hemoglobin genes. The fact that this is a hereditary disease means that it is not considered to be contagious. This disease comes in about six different forms, but the most severe of them all is sickle cell anemia. Sickle cell is an inherited disease that affects the red blood cells causing debilitating symptoms, however, with treatment people with this disease can quite possibly live an otherwise

Sickle cell disease (SCD), a genetic disorder, is an autosomal recessive disease (Brown, 2012). This means that two copies of the mutated gene, one from each parent, must be present for their child to develop the disease. If both parents have the sickle cell gene, there is a 50% chance that any one child will also have the sickle cell trait or gene. Also, if both parents have the sickle cell gene, any one of their children have a 25% of developing SCD. If only one parent has the disease, their children have a 50% chance of receiving the gene, but may never have the characteristics of the disease. The Center for Disease Control and Prevention (CDC, 2015), estimates that 90,000

The genetic disorder I will be discussing is Sickle Cell Disease. Sickle Cell Disease is an inherited blood disorder. Children who have this disease have two defective hemoglobin S genes, which they receive one from each parent. This gene occurs in chromosome 11. The sickle cell gene is passed from generation to generation in a pattern of inheritance called autosomal recessive inheritance. This means that both the mother and the father must pass on the defective form of the gene for a child to be affected. If only one parent passes the sickle cell gene to the child, that child will have the sickle cell trait.

Even the slightest changes within a single protein may greatly affect the health of a human being and their descendants. Sickle cell blood anemia is a type of blood disorder in which the proteins within the affected person have slightly mutated in order to form a sickle shaped cell. This can cause chronic health problems to a patient that has sickle cell anemia since their sickle shaped blood cells may obstruct their circulatory system. Despite this disease being chronic, a patient can only get sickle cell anemia if they have inherited it. Sickle cell anemia is most commonly inherited by African Americans and Hispanics. In other words, sickle cell anemia is a chronic disease in which a person is inheritably born with some sickle shaped blood

In the U.S. most people that inherit the sickle cell disease are African Americans. “about 1 in 13 African American babies are born with sickle cell trait.”(National institutes of health) But sickle cell can affect anyone.

The health problem of interest is sickle cell disease. Sickle Cell Disease is also called Sickle Cell Anemia. Sickle Cell disease is an inherited blood disorder which means it 's not contagious. Anybody that has sickle cell disease, must have two defective hemoglobin genes from each parent. If a person has only one hemoglobin gene that is sickled and the other hemoglobin gene is normal the person will have the sickle cell trait. Hemoglobin is a molecule in the red blood cell that helps carry oxygen. There is an error in the hemoglobin that causes the cell to be sickled. This disease deforms the red blood cells shape from a disc like shape meaning the red blood cells are healthy to a crescent moon shape meaning that 's unhealthy. The one thing in common that people either have the disease or trait is they are immune from catching malaria.

World Health Organization (WHO) has declared that hemoglobinopathies are the most widespread inherited disorder in the world (1). The principal hemoglobin disorder, sickle cell disease (SCD), is a recessively inherited disorder (2,3). Patients with both genes for SCD have the most severe form of the disease, sickle cell anemia (SCA). Following population migration, SCA is now seen throughout the world, as demonstrated by the employment of universal screening programs in the United States of America, in the United Kingdom, and in French overseas territories. It is predicted that human immigration will continue to rise with further globalization (4), the implementation of prevention measures, in low- and middle-income countries will be of direct