Substitution Reactions ( Sn2 And Sn )

Nucleophilic Substitution Samantha Gutierrez Nucleophilic Substitution Introduction: The purpose of this lab is to investigate how different factors affect the rate of SN1 and SN2 reactions. SN2 reactions proceed via a one step mechanism in which the incoming nucleophile attacks the electrophilic carbon center from the opposite side of the leaving group. This reaction mechanism implies that the stereochemistry of a chiral center will be inverted. SN1 reactions proceed via two steps, slow…

Synthesis of 1- Bromobutane An SN2 Reaction Theory: One of the methods of preparing alkyl halides is via the nucleophilic substitution reactions of alcohols. Alcohols are inexpensive materials and easy to maintain. However, they are a poor leaving group the OH group is a problem in nucleophilic substitution, this problem is fixed by converting the alcohol into H2O. Objective: The objective of this lab is to observe the synthesis of 1-bromobutane in an SN2 reaction, to see how a primary alky halide…

Name: Tonny, Chan Kar Yu, Student ID: 10297729 Date of Experiment: 19th March 2005, Group: B1 Title: Preparation of 1-bromobutane from 1-butanol by SN2 reaction Objective: 1. To study the preparation of 1-bromobutane from 1-butanol by an SN2 reaction 2. To study the method of purification of an organic compound by simple extraction 3. To study the test of identification of alkyl halide Chemicals and Apparatus: ~18.0 g 1-butanol, ~20.0 g sodium bromide, 15 ml of concentrated sulfuric acid, anhydrous…

nucleophilic substitution mechanisms (SN1 and SN2) with reactions that involved converting alcohol-containing compounds to alkyl halides. This experiment was conducted by combining the initial alcohol with reagents and heating under reflux when necessary. It was determined that mechanistic pathways of substitution depend principally on the structure of the initial alcohol; that is, substrate is considered primary, secondary, or tertiary. Synthesis of 1 (46%) was achieved through SN2 mechanism from…

Import Substitution Industrialization (ISI) Definition Government strategy that emphasizes replacement of some agricultural or industrial imports to encourage local production for local consumption, rather than producing for export markets. Import substitutes are meant to generate employment, reduce foreign exchange demand, stimulate innovation, and make the country self-reliant in critical areas such as food, defense, and advanced technology. What Does Import Substitution Industrialization (ISI)…

Experiment 15 & 16: Preparation of 1-bromobutane, an SN2 reaction Preparation of 2-chloro-2-methylbutane, an SN1 reaction Introduction The purpose of this experiment is to synthesize 1-bromobutane from 1-butanol and sodium bromide. In order for this reaction to reach completion there are four major operations that need to be performed. The four major operations include refluxing, simple distillation, separation, and drying. To begin, in order for the compounds to react they will be dissolved…

CH 220C – Organic Chemistry Lab Experiment 13: Electrophilic Aromatic Substitution: Nitration of Bromobenzene and Relative Rates of Reaction Rodan Devega Introduction Electrophilic aromatic substitution (EAS) reactions involve the replacement of a hydrogen atom bonded to an aromatic compound by an electrophile. The rate and direction of the EAS reaction depends on the functional groups present on the aromatic compound. The purpose of this experiment was to synthesize bromonitrobenzene by reacting…

Title: Relativities of Alkyl Halides in Nucleophilic Substitution Reactions Introduction: The purpose of this lab was to perform a comparison of relative reactivities of various alkyl halides with two different reagents, sodium iodine in acetone and silver nitrate in ethanol. (Below are the reaction equations). We used different substrates, which were primary, secondary, and tertiary. These substrates included 2-bromobutane, 2-bromo-2-methylpropane, 1-bromobutane ∞-Bromotoluene, bromobenzene…

REAC 714 Studying SN1 and SN2 Reactions: Nucleophilic Substitution at Saturated Carbon Date of Experiment: February 6, 2008 Objective: The objective of this laboratory experiment is to study both SN1 and SN2 reactions. The first part of the lab focuses on synthesizing 1-bromobutane from 1-butanol by using an SN2 mechanism. The obtained product will then be analyzed using infrared spectroscopy and refractive index. The second part of the lab concentrates on how different factors influence the rate…

nucleophilic substitution SN1/SN2 typically occur in a competitive regime. There are various conditions that define the predominant reaction mechanism taking place. Since SN1 leads to the racemic mixture, SN2 is more popular in asymmetric organic synthesis. So, detailed computational studies of model SN2 reactions have been carried out during the last three decades[2-6, 9]. The influence of solvation of the nucleophile with several common solvents on the rate constant of the reactions F-(Sn) + CH3Cl…