Synthesis And Characterisation Processes Of Pharmaceutical Co Crystals

An Erlenmeyer flask was used to accommodate the largest volume of recrystallization solvent calculated and was cooled in an ice bath to increase the yield of crystals. The solid was collected by vacuum filtration and washed with a small amount of ice water. The product is then dried to a constant mass by use of an oven and weighed. A small amount of the unknown was compared to two samples of acetanilide and phenacetin for a melting point range to determine the identity. The temperature of the unknown was recorded when the first trace of liquid can be seen and when the unknown was completely liquid.

Aspirin, Caffeine and Salicylamide were extracted from an over-the-counter pain reliever (BC Powder). These components were separated by manipulating their solubilities by adjusting the acidity and basicity of the solution. By doing this, the three components were forced into conjugate acid (or base) forms, causing selective solubility in either an aqueous or organic solvent. These layers were then separated by use of a separation funnel. Once separated, the components extracted were characterized by measuring the melting point and performing a TLC analysis. Also, the recovered aspirin from the first part of the experiment was recrystallized and compared to that of the

In experiment two, 1.48g of the unknown solid was recovered. From this mass, it was determined approximately 30mL of boiling water was needed for crystallization of acetanilide and about 121mL for phenacetin. Phenacetin would require more solvent because it is less

This compound has a marginally lower density than anhydrous sodium carbonate. Another typical hydrate is formed through the absorption of ten water molecules per one molecule of anhydrous sodium carbonate (sodium carbonate decahydrate). This particular compound is recognisable as it forms semi-transparent white crystals, which effloresce upon exposure to air. The solvent (water) dissolves the anhydrous sodium carbonate, at a solubility of 30.7g anhydrous sodium carbonate to 100g water.

Lead Compound is defined as a chemical compound that has pharmacological / biological activity that might be therapeutically useful, but may still possess suboptimal structure that requires modification to fit better to the desired target. Its chemical structure is used as a starting point for chemical modifications owing to develop potency, selectivity as well as pharmacokinetic parameters. In addition newly discovered pharmacologically active moieties may have poor drug likeness and may require chemical modification to become drug-like enough to be tested biologically/ clinically

The product was placed in a Craig tube and several drops of hot (100°C) solvent (50% water, 50% methanol, by volume) was added and heated until all of the crystals dissolved. The Craig tube was plugged and set in an Erlenmeyer flask to cool. Crystallization was induced once the mixture was at room temperature by scratching the inner wall of the tube. It was then placed into an ice bath for ten minutes until crystallization was complete. The tube was then

The product was then suspended in 2 ml of water with a stir rod in a 50 ml Erlenmeyer flask and heated to boiling. Water was added in one milliliter increments until all the product was dissolved (18 ml added total). The saturated solution was allowed to slowly cool, and gradual white crystal formation was observed. Recrystallized product was collected once more by suction filtration with the Hirsch funnel once crystallization ceased. Collected product dried on a watch glass for a week, weighed 0.14 g (1.2 mmol), and the melting point was 139°-141°

A glass isn’t a mineral because crystalline structure in which the atoms make up a mineral aren’t distributed randomly and cannot move around easily, and the atoms in a glass aren’t arranged in an orderly pattern. Moreover, both minerals and glasses are solids, and they can retain their shape, but a mineral is crystalline ,and glass is not because the atoms, ions, or molecules are the elements in a mineral are ordered into a crystal lattice, and glass doesn’t has those elements and disorderly arrange.

The week after, a recrystallization was performed on the previous week’s crude product. The product ethereal solution was first heated on a steam bath until dry. During the heating, a beaker of methanol was collected and also placed on the steam bath. Once the product was dry, it was cooled to room temperature and then placed in an ice-water bath. The now boiling methanol was added to the crude crystals and a recrystallization was performed. Once completed, the now purified product was collected via Buchner vacuum filtration and stored in drawer to dry for a week. Afterwards, a melting point range of the purified product was obtained by using a Mel-temp apparatus. Lastly, an

All minerals have a crystal structure.A mineral is a naturally occurring, Inorganic, Solid, with a unique chemical composition, and a crystalline structure. (Class Notes 11/03/15). The minerals form when the magma starts to cool inside of crust, they started to cool in the water and water start to evaporate ,the liquid cool and mineral get a solid form.Citation (Video-How the Earth Made Us episode 1:deep earth). The Crystal that were made in lab weren’t not because they formed by using man made formula. The August Birthstone was a minerals because birthstone by geologic processes in rocks in their natural environment.(http://www.burkemuseum.org/geology/birthstones/)The

By following the above procedure, it was determined that my hypothesis was accepted. Initially, I predicted that sugar will have the best solution for making crystals because the sugar dissolves better in water and will be able to make the best crystals in size and shape. During the experiment, I investigated which solution made the best crystals. However, there was some inconsistencies and consistencies. The inconsistencies and consistencies were finding the perfect spot to put the solutions,the crystals forming, and the right materials. The first inconsistency was finding the perfect spot to put my solutions. It was very difficult for me

SV (figure. 1) is antihyperlipidemic compounds which can reduce about 30% of LDL and total cholesterol in the body. In addition, SV was more tolerated by the body [1] than other antihyperlipidemic drugs, so that it became the drug of choice for most patients with hyperlipidemia [2]. Unfortunately, its solubility in water is very low, and it correlates with very low bioavailability [3]. One potential method to improve the simvastatin's solubility was made by co-crystal form. Co-crystal is a crystal whose a structured arrangement, consists of two main compounds (the active substance and the crystal-forming components) known as co-former with a certain stoichiometric ratio [4]. ASP and SAC are two examples of co-formers that used to increase solubility

These forms can be classified into nanospheres and nanocapsules. Nanospheres are solid, monolithic spheres made of dense polymer matrix, wherein the active ingredient is dispersed, while nano-capsules creating reservoirs, made of polymer membrane contiguous the drug in solid or liquid form (Bucolo and Salomone, 2012). The drug absorption mechanism from nano-spheres or nano-capsules after their application to conjunctival sac includes dispersion of the drug and degradation of the polymer (Rathore, and Nema, 2009). The advantages of nanoparticles as an ophthalmic dosage form, rise corneal infiltration and a larger dissolution area, which enhances of the drug bioavailability when compared to conventional eye drops (Bucolo, and Salomone,

The zeta potential was determined and it was found to be -39.7 mV which indicates good physical stability. Stability studies carried out for a period of 9 weeks showed negligible changes in the characteristics of ethosomes and further the loss of drug is not more than 4 %. Hence it is concluded that a successful ethosomal formulation can be formulated for finasteride. Further this can be exploited commercially into a suitable drug

According to other sources, the demand can grow up to 8.4% annually just for nylon alone. Since 2006 new and expanding uses of nylon-6 resins include wire and cable coating, hardware & furniture accessories, and electrical parts (7). According to the Journal of Molecular Structure, significant research has been conducted on a new CL-20/Caprolactam co-crystal. Overall co-crystallization is an effective way to improve both physical and chemical properties of a crystalline solid. In this particular study, co-crystallization has been found to be an effective way to improve performance in high explosive 2,4,6,8,10,12-hexanitrohexaazaisowurtitane (CL-20). This particular co-crystallization effort will be beneficial in altering the density, melting point, and sensitivity of explosives. Due to its low sensitivity, the CL-20/Caprolactam co-crystal is planned to be used as a desensitizer in other high