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The Common Causes Of Weight Loss

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One of the most common causes of weight loss is diabetes, this can range from a couple of pounds to two-three stone. Weight loss is usually due to the increased metabolism and breakdown of muscle and fat due to insulin deficiency. Fluid depletion can also cause weight loss from both Polydipsia and Polyuria. When an individual presents with these features it is important for them to be picked up quickly otherwise Ketoacidosis can occur which may be fatal. Ketones are made up of acetone and two organic acids- beta-hydroxybutyric acid and acetoacetic acid. The liver and other cells can only process limited amounts of fatty acids, lipids and ketones at any given time, any excess of keytones is then secreted into the blood causing ketoacidosis. The binding of ketoacids and bicarbonate buffers within the blood, leading to an eventual decrease of PH in the blood due to decreased levels of serum bicarbonate (Gould and Dyer, 2011: 551). As dehydration occurs within the kidneys the demand on glomerular filtration decreases and so to does the excretion of acids leading to decompensated metabolic acidosis. Diabetic ketoacidosis or hyperosmolar coma are mostly due to the hyperosmolarity of the blood, secondary to hyperglycemia and the result of this can be fatal if not treated within a short period of time Less obvious presentation includes tiredness and weakness which is very common in uncontrolled diabetes. Alongside these presenting features comes visual blurring and fungal

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