The Effects Of Insulin On The Body

Diabetes, Diabetes Mellitus, is a chronic illness this means that it has no cure and the symptoms persist over a long period of time. This illness is a result of an imbalance of hormones, insulin, produced in the pancreas. Insulin plays an important role in how the body uses food. Insulin enables the cells in the bloodstream to absorb and use glucose for fuel. If the pancreas produces too little or no insulin or if the insulin doesn’t work properly the person may become diabetic. Therefore, diabetics are not able to properly convert food into fuels needed by the body to function, which can seriously lead to physical consequences.

Insulin for diabetes was discovered in 1921 at the University of Toronto by Sir Frederick G. Banting, Charles H. Best, and JJR Macleod. James B. Collip subsequently purified it, and one year later on January 11, it was put to use on a young 14 year old boy named Leonard Thompson; a patient at Toronto General Hospital. Once the substance was delivered, it was found that the extract was so pure that he suffered an allergic reaction, and further injections were cancelled. James Collip worked for the next 12 days on improving the ox-pancreas extract, and the second dose given to Thompson on January 23 was completely successful. Prior to this, a type 1 diabetic would be put on a starvation diet, or be limited to a calorie intake of around 450 calories per day, and would only live a few extra months. Leonard Thompson lived another 14 years, until 1935 when he died of pneumonia at the age of 28.

First and foremost, Dr. Frederick Banting was able to isolate insulin and use it to treat the metabolic disorder diabetes which has benefited Canada. As a result, numerous individuals have been able to receive treatment which has reduced the number of deaths. This decrease in mortalities has also lowered the number of debilitating conditions resulting from diabetes. In fact, the mortality rate for diabetes over the past forty-five years has dropped by over fifty percent (Center for Disease Control and Prevention). This decrease clearly indicates that the death rates for diabetes is gradually declining. This trend can be followed from the time insulin was discovered and has increased the prognosis and quality of life for many people. In addition, the number of diabetes cases in Canada has risen by almost thirty percent over the past twenty years (Public Health Agency of Canada 2). Although, the number of people living with diabetes is significantly

Diabetics have an insulin problem Diabetes is a result of insulin not performing its job correctly. Since insulin does more than remove glucose from the bloodstream, including producing proteins, storing fats, and other metabolic processes, diabetes can have severe consequences. If it is not treated properly diabetes can lead to heart disease, stroke, eye problems (including blindness), kidney failure, problems with teeth and gums, male sexual problems, nerve problems, and circulation problems. The circulation problems could result in foot or leg amputation (Reddy 2).

Diabetes is a disease that affects the body’s ability to produce or use insulin. It is a precursor to numerous other diseases, which can quickly deteriorate patient’s health if

Diabetes Mellitus is not a new disease. It was first recognized in ancient Egypt around 1500 B.C.E. It was considered a rare condition in comparison to present times. In 1812, diabetes was acknowledged as a clinical disorder. However, its prevalence at the time was not well documented. During those time periods, diabetes was considered fatal (Polonsky, 2014). The most significant progress came with the discovery of insulin. In 1921, Frederick G. Banting, MD and then student assistant, Charles H. Best, made the discovery of insulin. This discovery led Dr. Banting to being

This could lead to effects such as blindness, strokes, and heart disease. Until a method of injecting insulin appeared, it was difficult to tame diabetes. Diabetes affects many areas in the body but usually attacks the eyes, blood vessels, arteries, and kidneys. Despite this, scientists are still not sure what causes this disorder. According to Dr. Moalem, the reason is “a complex combination that can involve inheritance, infections, diet, and environmental factors” (Moalem, 25) so it is difficult to pin-point one exact reason. Hence, because of the lack of information, researchers still haven’t found a cure for

The development of insulin saved many lives throughout the 1920’s. Insulin allows your body to turn blood sugar into energy, and diabetes patients don’t have an important hormone called insulin. In fact, thousands of people had this issue. In the 1900’s, the only treatments for diabetes were starvation diets and very strict exercise program. Dr. Frederick Bating, the inventor of insulin, had spent a lot of his time studying the disease of diabetes. He thought if he could isolate insulin in animals, it would be possible to use it to treat people with diabetes. Later on his theory proved to be correct. Dr. Frederick Banting needed a lab to test his theory and work on it so he could have insulin mass produced and treat the disease of diabetes.

regulate glucose levels had artificially been altered (“The Discovery of Insulin”). The results were groundbreaking and the diabetic dogs responded well to the injections, marking a major step forward in diabetes research (“The Discovery of Insulin”). Through the help of Professor John Macleod of the University of Toronto, they were able to continue their research (“The Discovery of Insulin”). Finally, in January of 1922, testing Dr. Banting’s developments in diabetes treatment on human beings had finally been completed and the results led to the ultimate development of the insulin treatment that is still used to this day (Simoni, Hill and Vaughan 31).

During the 1920’s, many discoveries happened in the medical field. In particular, a major discovery was insulin. It helps save many lives since the 1920’s until today. The discovery of insulin resulted in a Nobel Peace Prize. It is an extremely significant hormone in the body of humans and animals. There are many facts people should be aware of about insulin like how it became discovered, what it is, and how it helps treat diabetes.

Diabetes is a disease in which the body has an inability to produce any or enough insulin which will cause the blood sugar to spike or rise rapidly. There are two different types of diabetes as mentioned The first type is type one which is when the person’s pancreas cannot produce any insulin cells at all and when it comes to type two, their body produces some insulin but due to reasons like weight or food habits, their body can’t produce enough properly. All in all, people with both types of diabetes struggle to produce insulin. “ The stomach and small intestine convert the carbohydrates you eat into glucose, a kind of sugar. Glucose is the body’s main fuel. When released into the bloodstream as “blood sugar,” glucose circulates through the body and feeds the cells. Insulin enables cells to take that glucose in.”(Teen Health and Wellness). This is important because everyone in the world has this

Insulin is one of the animal cell product which is widely known for its uses for diabetes treatment. Scientifically, insulin is one type of hormone made in the pancreas. Mostly of the food intake by human beings will be converted into glucose which then travels into the blood and all of the cells in our body, this is where the insulin production is crucial in aiding the glucose’s movement from the blood into the body cells.

Normally insulin is released from pancreatic β cells into circulation in response to increases in plasma glucose levels and binds to its receptors and activates signaling cascades to promote glucose uptake and utilization into tissues such as liver, muscle and fat (Akintola and van Heemst, 2015). In the central nervous system (CNS) insulin play a minor role in the regulation of glucose uptake, but known to have and play multiple behavioral and metabolic effects, influencing eating behavior, peripheral metabolism, cognition and regulating synaptic plasticity in brain regions like the hippocampus (Morton et al., 2006; Akintola and van Heemst, 2015). In obesity, type 2 diabetes (T2D), and neuropathological processes where the shared characteristic

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Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.