The Last Page Of The Results Starting On Line 18 States:

1066 WordsJan 11, 20175 Pages
The last page of the results starting on line 18 states: The overall group-by-time interaction for the mixed-model was statistically significant only for SBP (p-value=0.0105) meaning that the PA group had significantly reduced SBP while the placebo group had increased SBP during-intervention. This does not appear to be consistent with the analysis. Unless I 'm misinterpreting, the results indicate that there was a difference between the two groups at that time point, not that each had a significant difference from the baseline. If this is the case, the conclusion should also to be adjusted accordingly. Response: We are sorry not to make it clear in the manuscript. While the reviewer’s interpretation was correct, we tried to explain how…show more content…
In other words, the p-value (p=0.003) included in Figure 3 was from testing whether 107.32–110.19 = –2.87 in PA was significantly different from 111.68-110.95=0.73 in PA-P. Therefore, our results were correctly reported in the submitted manuscript. In order to clarify the interpretation, we have now modified the paragraph and included the revised sentences in Page 9 such as “The overall group-by-time interaction for the mixed-model was statistically significant only for SBP (p-value=0.0105). The ad-hoc pair-wise comparison further revealed that this was driven by the significantly different changes from baseline to during-intervention between groups. In detail, the PA group had significantly reduced SBP from baseline to during- intervention while the placebo group had slightly increased SBP (p-value = 0,003) in Figure 3.” An additional weakness of the study that should be made explicit is that it appears that the person applying the treatment and placebo knew of the hypotheses of the study and although care was taken to ensure they weren 't aware of the treatment until 30 seconds before the application, a small change

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