The Role Of Trpm2 Channels On Diabetes

2798 Words Nov 26th, 2014 12 Pages
PSL452H1F (Dr. Feng) Term Paper (Due on November 15, 2014)
Topic : The role of TRPM2 channels in diabetes
TRPM2, its Biophysical Properties & as Potential Therapeutic Drugs for Diabetes Mellitus
Yunjong Han, 997267443
Introduction
Diabetes mellitus (DM) is considered as a metabolic disorder and is the condition, abnormality in blood glucose level
(usually high glucose in blood) due to problems in insulin secretion from the pancreatic β-cells or insulin insensitivity of the insulin receptors on insulin sensitive tissues (Aathria & Jain 2014;
Liamis et al. 2014; Silverthorn 2010).
There are two types of diabetes; type 1 and type 2. Patients with type 1 DM have problem with insulin secretion from their pancreatic β-cells and patients with type 2
DM have problems with insulin sensitivity of insulin receptors on the insulin sensitive tissues (Ahmad 2014;
Silverthorn 2010). Insulin is a hormone and it is produced by β-cells of the islets of
Langerhans in pancreas in response to high glucose level in blood (Ahmad 2014).
Type 1 DM is also known as insulindependent
DM (Kalant et al. 2007).
Discovery of insulin and treatment of type
1 DM are discovered at the University of
Toronto by Banting and Best in 1921
(Aathria & Jain 2014; Ahmad 2014).
Insulin helps to uptake of blood glucose by mobilizing of the type 4 glucose transport (GLUT-4) into certain tissues
(Kalant et al. 2007). Etiology of type 2 DM is currently known to be because of lack of exercise and nutritional consequences…
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