The Role Of Trpm2 Channels On Diabetes

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PSL452H1F (Dr. Feng) Term Paper (Due on November 15, 2014) Topic : The role of TRPM2 channels in diabetes TRPM2, its Biophysical Properties & as Potential Therapeutic Drugs for Diabetes Mellitus Yunjong Han, 997267443 Introduction Diabetes mellitus (DM) is considered as a metabolic disorder and is the condition, abnormality in blood glucose level (usually high glucose in blood) due to problems in insulin secretion from the pancreatic β-cells or insulin insensitivity of the insulin receptors on insulin sensitive tissues (Aathria & Jain 2014; Liamis et al. 2014; Silverthorn 2010). There are two types of diabetes; type 1 and type 2. Patients with type 1 DM have problem with insulin secretion from their pancreatic β-cells and patients with…show more content…
2007). TRPM channel is melastatin-related receptor and is the subfamily of TRP (Transient Receptor Potential) ion channel (Harteneck 2005). There are several functional TRPM members; TRPM1 to TRPM8 (Harteneck 2005). This paper mainly focuses on TRPM2 channels. TRPM2 is known to be involved in insulin secretion from pancreatic β- cells (Faouzi & Penner 2014). TRPM2 is a Ca2+-permeable channel and it is activated by various molecules but it usually regulates intracellular Ca2+ concentration, which is important for other downstream cascades (Sumoza- Toledo & Penner 2014). TRPM2 is also found various tissues in the body but especially it is found inpancreatic β-cells of the islets of Langerhans (Sumoza- Toledo & Penner 2014). Therefore, TRPM2 activation and inactivation may affect insulin secretion in the pancreatic cells and discovery of TRPM2 related pharmacological molecules might be helpful to treat diabetes mellitus. Molecular and Biophysical Properties of TRPM2 TRPM2 is a member of TRPM subfamily. TRPM2 channel have six putative transmembrane proteins with C-terminal and N-terminal (Figure 1; Fleig & Penner 2004; Jiang et al. 2010). TRPM2 channels form homomultimer (homotetramers), Yunjong Han, 997267443 ! 2 which have four subunits of six transmembrane proteins (S1 to S6, 24- transmembrane in
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