The Survival Rate Of Systemic Lupus Erythematosus

873 WordsApr 10, 20154 Pages
SLE is an autoimmune disease that is more common in women versus men. Ninety-six percent of SLE cases are in women, whereas only four percent of SLE cases occur in men. The survival rate of systemic lupus erythematosus has improved due to many factors such as earlier diagnosis, better management of disease and prevention of organ damage. Despite these advances in care, the life expectancy of patients with SLE remains, lower than the general population. SLE may also be associated with an increased prevalence of cervical cancer and other cancers thereby shortening their life spans. Cervical cancer is caused by the human papillomavirus (HPV) and is an important cause of morbidity in women. Cervical cancer is the second most common malignancy in women worldwide and despite recent discoveries in vaccines; it remains a problem in developing third world countries. Studies have indicated that HPV infections and cervical cancers are increased in patients with systemic inflammatory diseases most importantly with systemic lupus erythematosus. This increase in HPV infections and transforming infections could be due to either SLE itself or to the immunosuppressive treatments that are given to patients with autoimmune diseases. Studies have shown that immunosuppressed women with HIV have increase chance of developing cervical cancer. Mendoza et al found that levels of B cell lymphocytes and natural killer cells were lower in SLE patients who were under immunosuppressive therapy
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