Thesis On Psoriasis

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Psoriasis is a disease of chronic systemic inflammation that involves not only the skin, but also internal organs. The frequency of Non-alcoholic fatty liver disease was found to be significantly greater in psoriasis patients with increased risk of atherosclerosis and cardiovascular disease. A large number of immunes is found in Psoriatic skin and this immune produce chemokine’s, cytokine and inflammatory molecules. The exact role of genetics in psoriasis is still unclear and an overlap between some psoriasis loci and those identified in other autoimmune or inflammatory diseases has been reported.


Psoriasis affects 2–3% of the European population. It is common found less in an individual of Asian descent (0.1% …show more content…

Different number of studies base on association on a candidate-gene approach has been conducted to identify genes underlying susceptibility to PsA. Since the PSORS1 locus within the MHC region on 6p provides the strongest linkages with psoriasis in Genome wide linkage scan, also candidate gene within this region have been investigated. The number of genes for a gene dense region code are important in the immune response, including HLA and non -HLA genes. HLA alleles have been associated with both psoriasis and PsA23. It is not clear whether the associate HLA described are with psoriasis or with PsA, or both because most of the patient with PsA have psoriasis. HLA alleles that are peculiar to PsA are HLA-B27, B7, B38, and B39.HLA-B13, -B16, and its splits -B38 and -B39, B17 and Cw6 were described as being psoriasis associated arthristis or not24. The possible biologic significance that are assciated with psoriasis is recognize to be nine genes and this genes include HLA-B, HLA-C, PSORS1C3, OTF3, HCR, SPR1, SEEK1, corneodesmosin (CDSN), and TNF-α. 25- 31. Genomic DNA sequences and recombinant haplotypes suggested that HLA-Cw*0602 is the allele diseases at PSOR1. It has been noted that gene within this region have been investigated with PsA32. A study from a metaphysis shows that there is an association between …show more content…

In the Nurses’ Health Study II, increased body mass index (BMI) correlated with an increased incident rate of psoriasis, and hip circumference and waist-to-hip ratio were all associated with a higher risk of incident psoriasis. 37 The psoriasis that are associated with metabolic syndrome and increase risk of cardiovascular disease are non-alcoholic fatty liver disease (NAFLD) and chronic plague. . NAFLD is the hepatic manifestation of metabolic syndrome, with its key component being visceral obesity. 38 The prevalence of NAFLD is 10–24% of the general population worldwide, increasing to 57.5–74% in obese individuals. The mortality was increased in patients with NAFLD compared with the general population and in the National Health and Nutrition Examination Survey (NHANES III) study, the NAFLD cohort had both increased overall mortality and liver-related mortality compared with individuals without liver disease. 39 While in most patients, NAFLD does not progress beyond simple steatosis, it may progress to Non-Alcoholic Steato-Hepatitis (NASH). The prevalence of NASH also correlates with obesity, with waist-to-hip ratio and abdominal obesity reported to be predictors of NASH. Diagnosing patients with NAFLD and identifying those with NASH is challenging, as they are generally asymptomatic. Clinical presentation and current radiological modalities may not be reliably to

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