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Titrimetric Analysis Of Calcium Acetate

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Faculty of Pharmacy
Analytical Chemistry Department
Assignment Topic: Calcium Acetate
Course Title: Analytical Chemistry 2
Course Code: PC223
Lab Group: F3
Submitted To: Dr. Souha Hosam
Prepared By: Manar Mohamed Abd El Aziz - 170339
Due Date: 23-10-2017 Introduction:
There is more than one method to be used in the quantitative analysis. One of these methods is titration method which used in the titrimetric analysis. Titrimetric analysis is the quantitative chemical method which determines the accurate concentration of sample to react with another known volume and concentration substance. Titrimetric analysis was been called volumetric analysis as it expresses the analysis method better than volumetric analysis. The standard in titrimetric
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It has slightly acetic acid odour and melting point at 160C. Calcium acetate is highly soluble in water, partially soluble in alcohol, and insoluble in benzene and acetone. Its stability is very hygroscopic. It produces acrid smoke and fumes in decomposition at 160C and has 6-9 pH.
Assay of Calcium Acetate:
European Pharmacopeia: Add 0.150 g of calcium acetate to 100 mL of distilled water, dissolve, and carry out the complexometric titration of calcium (2.5.11). 1 mL of 0.1 M sodium edetate is equivalent to 15.82 mg of C4H6CaO.
The assay method is complexometric titration.
British Pharmacopeia:
Add 0.150 g of calcium acetate to 15 ml of distilled water, dissolve, and add 5 ml of diethylamine. Titrate with 0.1 M sodium edetate and determine the end-point using methylthymol blue mixture.
The assay method is titration.
American Pharmacopeia:
Add about 300 mg of Calcium Acetate to 150 mL of water containing 2 mL of 3 N hydrochloric acid. While stirring, preferably with a magnetic stirrer, add about 30 mL of 0.05 M edetate disodium VS from a 50 mL buret. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue, and continue the titration to a blue endpoint. Each mL of 0.05 M edetate disodium is equivalent to 7.909 mg of C4H6CaO4.
The assay method is
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Cool, transfer to a 250-ml volumetric flask, dilute to volume with water, and mix. Transfer 50 ml of the solution to a 400ml beaker, add 100 ml of water, 25 ml of sodium hydroxide TS, 40 mg of murexide indicator preparation (an alternative indicator is hydroxynaphtol blue, of which 0.25 g is used - in this case the naphthol green TS is omitted), and 3 ml of naphthol green TS. Titrate with 0.05 M disodium ethylenediamine-tetraacetate until the solution is deep blue in colour. Each ml of 0.05 M disodium ethylenediaminetetraacetate is equivalent to 7.909 mg of
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