In this report, the condition of diabetes mellitus type 2 (Type 2 diabetes) will be examined. The first part of this report will focus on the aetiology of the condition, explaining how and why type 2 diabetes develops in patients. The pathophysiological changes attributed to the disease will then be outlined, with the major changes that contribute to the development of the condition being highlighted. The report will then conclude with a description of how these pathophysiological alterations produce the signs and symptoms associated with type 2 diabetes.
AETIOLOGY
Type 2 diabetes is a chronic metabolic disorder caused by a combination of both genetic and lifestyle factors, characterized by changes in the body’s reaction to insulin and the
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This change in the metabolism of glucose is preceded by a slow decline in function of pancreatic β cells and a gradual increase in the body’s resistance to insulin (14). These changes in insulin resistance and β cell function are the core pathophysiological modifications of type 2 diabetes. Genetic and lifestyle factors previously highlighted in this report result in individuals with tissues resistant to insulin and a decrease in the functionality and mass of pancreatic islet …show more content…
Hyperglycemia presents with three main clinical features which are shared between type 1 and type 2 diabetes. These are polyphagia (increased hunger), polydipsia (increased thirst) and polyuria (increased urine production and excretion) (21).
As the muscle and liver cells decrease their uptake of glucose due to resistance to insulin, these cells are starved of nutrients and thus stimulate hunger centres in the brain to seek out more food to intake, causing an increase in hunger (21). The increased glucose in the blood provoked by the decrease in circulating insulin causes the kidney transport threshold for glucose to be exceeded, meaning that not all the glucose in the blood can be reabsorbed after being filtered through the glomeruli. This results in some glucose to be present in the urine (glycosuria), creating an osmotic gradient as glucose in the urine causes water to be extracted from the blood into the urine, which in turn provokes large amounts of water to be produced and excreted (21). As a result of the increased dilute urine production and excretion, intracellular dehydration triggers the thirst response in the hypothalamus in order to rehydrate the body (21).
Type 2 diabetes mellitus (T2D) is the most common form of diabetes (American Diabetes Association, 2012). T2D is so prevalent that it is estimated to be the fifth most common cause of death worldwide (Yates, Jarvis, Troughton, and JaneDavies, 2009, p. 1). T2D manifests when the body is unable to metabolize glucose properly, resulting in elevated blood sugar, debilitating fatigue, and other serious complications such as distal limb amputations, kidney failure, and blindness. The generally accepted causes of T2D include diet, sedentary lifestyle, and obesity.
Type 2 Diabetes is a disease that is found in a variety of age groups around the world. This disease is growing at a rapid rate and it is impacting the health of this generation and future generations to come. Diabetes is a disease that impairs the body’s ability to produce or respond to the insulin hormone produced by the pancreas. The insulin allows for the glucose to be effectively used as energy throughout the body. Diabetes causes carbohydrates to be abnormally digested, which can raise blood glucose levels. This means that the glucose is not being taken up by the cells that need it. The cells cannot take up the excess glucose that has accumulated in the blood, so it is excreted through the urine. This can lead to problems with the kidneys, central nervous system, heart, and eyes because high blood glucose can damage the blood vessels of these organs. This diseased is managed by adopting a diet low in fat and high in fiber, increasing physical activity, losing excess weight, and not smoking. If this
Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.
Insulin resistance is the first physiological change occurring in type two diabetes. In these type two diabetic patients, insulin is unable to move glucose into liver, kidney and muscle cells although insulin is able to attach properly to the cell surface receptors. In order to rectify this, most patients with type two diabetes start secreting normal to very high levels of insulin, which can initially overcome this resistance. After a while, the pancreas cannot keep up with this high insulin production and the cells become resistant to glucose intake. Persistent hyperglycemia or high blood glucose levels are not desirable since this causes damage to the beta cells of the pancreas that produces the insulin hormone. This damage to beta cells further hampers insulin synthesis and patients at this stage are categorized as full-blown diabetic. Such patients consistently show a hyperglycemia state even after hours of fasting ( Hinkle & Cheever,
Type II diabetes is a mixture of both genetic and environmental factors. It is a metabolic disorder that affects the way the body processes blood sugar due to the fact that the body cannot produce enough insulin. The victim often feels fatigued and thirsty that leads to frequent urination. Obesity is believed to be the primary cause of Type II diabetes to those who are genetically predisposed. Based on the American Diabetes Association, non-Hispanic blacks are second in being diagnosed with diabetes with 13.2%. Type II diabetes can come with many effects
Diabetes mellitus is a group of metabolic disorders characterized by inadequate insulin secretion by the pancreas or cellular destruction leading to an insulin deficiency. Depending on the cause of the insulin shortage, diabetes can be subcategorized into type I and type II. Type I diabetes (T1DM) is usually mediated by the destruction of b-cells in the pancreas resulting in decreased insulin production and secretion. Type II diabetes (T2DM) is the failure of these b-cells to secrete adequate amounts of insulin to compensate for insulin resistance and increased gluconeogenesis combined with an overall resistance to the insulin action (8., 1997). T2DM accounts
Type 2 diabetes is a disease that stops a person from producing insulin which regulates the blood sugar. Type 2 diabetes isn't genetic and is caused by unhealthy eating, not exercising and an unbalanced diet. There is a cure for type 2 diabetes, which includes injecting yourself with insulin, and by changing your eating habits and exercising daily it can contribute to a more faster recovery.
Diabetes Type 2 is a lifelong disease that develops slowly. Type 2 diabetes causes the person fat, liver and muscle cells not to respond correctly to the hormone insulin, as a result the glucose doesn’t get into these cells to be stored in energy, which causes the levels of blood sugar in the blood to increase and eventually causing damage to the nerves and small blood vessels of the eyes, kidneys and heart and lead to atherosclerosis or the hardening of the arteries which causes a heart attack or stroke. Common symptoms of diabetes type 2 is fatigue, hunger because the body can’t process the food properly so its expelled through urine, increased thirst because the person keeps peeing out everything they are consuming which makes them thirsty,
Some of the most common signs and symptoms of diabetes are polyuria, polydipsia, and polyphagia. These symptoms cause a ripple effect and one causes another to happen. Polyuria is excessive urination that is very common in diabetes. This happens when excess sugar builds up in the blood, during which the kidneys work harder to filter and absorb the extra sugar that cannot be reabsorbed. This excess sugar is excreted in the urine along with large losses of water. This is also known as osmotic diuresis. This causes frequent urination and also can cause dehydration (Mayo Clinic, 2010). The dehydration then causes polydipsia, also known as excessive thirst. This is also caused by the increased level of blood glucose. This again, is caused when water is pulled from the cells and also from the large loss of water. When you lose sugar with polyuria you also lose calories which cause polyphagia. The body tents to hold on to the sugar and prevent it from reaching the cells which makes the body use fat stores and cellular protein for energy. This then leads to excessive hunger (Mayo Clinic, 2010).
Type 2: In type 2 diabetes, the pancreas produces insulin, however the body doesn’t respond to it as it should, this is because the quantities of the insulin being produced are insufficient, or the body’s cells just don’t react to it and so the glucose levels in the system remain high. Type 2 diabetes is a ‘progressive disease’ and can get worse if it is not managed properly. Long term effects of high blood sugar can result in heart disease or kidney
Type 2 Diabetes is a chronic condition that affects the way your body metabolizes sugar (glucose). With type 2 diabetes your body resist the effects of insulin (a hormone that regulates the movement of sugar into your cells) or does not produce enough insulin. As a result the gates of the cells cannot open to let glucose in, if glucose cannot enter the cells, it builds up in the bloodstream and causes blood glucose levels to rise.
Diabetes, also referred to as diabetes mellitus is the 7th leading cause of death in the United States of America each year. Diabetes is diagnosed when a person has too much blood glucose. People can have a high blood sugar due to not producing enough insulin, or the body cannot properly react to the insulin. People with diabetes often have a couple of similar symptoms including frequent urination, thirstiness, hungriness, blurry vision, fatigue, slow healing of wounds, and tingling in hands and/or feet. There are two types of diabetes diagnosed as type one or type two. An individual has type one diabetes when their body doesn’t produce insulin. An individual has type two diabetes when their body doesn’t produce adequate insulin for the body’s
The first diagnose of type 2 diabetes is the patient BMI. The patient BM is over 30 which indicates they are obese and could be at risk for diabetes. Overeating pressures the membranous network inside of cells called endoplasmic reticulum (ER). When the ER has more nutrients to process than it can handle, it sends out an alarm signal telling the cell to reduce down the insulin receptors on the cell surface. This interprets to insulin resistance and to insistently high concentrations of the sugar glucose in the blood. Which is one of the certain signs of diabetes. The second and third diagnose of diabetes is frequent urination and thirst. The reason why the patient urinates and become thirsty is because glucose leaks into your urine, which pulls
Type II Diabetes, also known as diabetes mellitus, is also called non-insulin-dependent diabetes or aadult onset diabetes. It is a medical disorder that, due to a number of factors codependent with the modern world, is characterized by higher than normal blood glucose levels that play havoc with insulin deficiency and resistance. Insulin resistance means that cells do not respond appropriately when there is free insulin in the blood system. Essentially, they body is reacting to an improper balance of sugars and insulin. Because obesity is often present, research suggests that even thought the mechanisms controling glucose and insulin are unclear, the adopose tissue likely
As previously stated, there is Type 1 and Type 2 diabetes. Due to the differentiation, the etiology of diabetes is divergent. Being insulin-dependent, Type 1 diabetes is brought about by the immune system eradicating beta cells, leading to the deficiency of insulin. In contrast, Type 2 diabetes has a basis that can often times be prevented to an extent (“Causes of Diabetes”, 2014).