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Understanding The Risk Factors Associated with Pathogenic Abnormalities

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An advantage of thinking more comprehensively about the pathogenic abnormalities that impair healing is that one can view existing therapies and procedures in a different light, and with different justifications. For example, the process of surgical debridement of diabetic foot ulcers becomes more than simply removing necrotic tissue; at the same time, one is also removing the excessive bacterial burden and, possibly, the phenotypically abnormal cells that may be present in and around the wound. Another example is the removal of edema, which is also critical in the management of diabetic ulcers. Edema removal decreases the chronic wound fluid that has been shown to be deleterious to resident cells and that may enhance bacterial colonization. Therefore, existing therapies can be integrated better with pathophysiological principles [68]. The risk factors like obesity and very high levels of blood glucose were found in our study which contributed to the formation of chronic wounds along with microvascular complications. The locations of ulcers were mostly on the lower limbs which can be due to poor hygiene and negligence of the wound treatment if formed. The patients also revealed the high levels of C reactive protein which can be said that there is high risk of ischemic foot leisions and amputations and clinical treatment failure in diabetic foot patients [69].
There was an increased serum creatinine levels in patients with chronic wounds which can be admitted to

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