What Is Nanotechnology Based Drug Delivery System

Using the magnetic fields, the scientists can remotely control the nanobots to swim anywhere through the bloodstream. There are many colleges and companies working on developing nanobots. One of these leading companies is Google who is using their Google X research division to make nanobots in condensed into a pill. In the article “Google nanobots: Early warning system for cancer, heart disease inside the body” written for news website RT, it states, “The pills will be able to identify minutes changes in body chemistry and act as an early

Nanocarriers (NCs) have emerged as a favored drug delivery approach towards improving the anticancer benefits of several bioactives for cancer therapy with recent reports showing the application of NC systems in clinical settings [18]. The NCs with size < 100 nm have been associated with enhanced permeation and retention effect (EPR) due to the presence of leaky vasculature in the tumor tissues which contributes to its enhanced efficacy. Also recently, NCs have shown to be effective in the treatment of malignant mesothelioma [19]. A recent study by Kanai et al. showed that the NC albumin-bound paclitaxel and carboplatin (nabPC) repetitively achieved tumor regression in malignant mesothelioma

Nanobots are invented to solve problems concerning cancer. Uncontrolled mitosis leads to cancer which have higher tendency to happen when mechanism that controls the cell is distrupted. In 2012, according to the World Health Organization, cancer is one of the leading cause of fatal. In Canada, approximately 30% of deaths are caused by cancer and abouy 191,300 new cases of cancer are expected in the year 2014. Annually, 14.1 milllon of new cases were reported while globally, there were 8.2 billion of deaths. Cancer cells need to compete with normal cells to obtain sufficient nutrient and energy for growth. Cancer cells divide out of control and are able to able to spread to other cell, tissue and organ which will result in malfunction and death.

Some new advances in science and technology opens up new opportunities in the fight against cancer, not only to treat the disease, but also to treat many forms of cancer permanently.

Nanotechnology has immense numbers of avenues and directions that have been created, especially in the treatment of cancer. It is only projected to become a bigger field that’s more accurate as time passes. But is nanotechnology sustainable and though accurate, strong enough to be the best cancer therapy system? Is lung cancer too difficult to treat with nanotechnology due to its metastatic tendency? And is nanotechnology the best direction that we could be following in our quest for the treatment of cancer without damaging other tissues? As we discover more technology and tools, problems pop up as quick as we can solve past ones – toxicological aspects of cancer treatment, cost effectiveness and the like. Can these wonder child molecules created

But today, we propose for Nanomedical robots, since they will have no difficulty in identifying the target site cells even at the very early stages which cannot be done in the traditional treatment and will ultimately be able to track

In this study, published in the scientific journal Advanced Materials, Quanyin Hu has created a better way to administer doxorubicin and TRAIL, two anticancer drugs. By using platelets, part of the blood that aids in clotting, to mask the foreign drugs from the body's defense system, these bioengineers caused the drugs to stay in the body for a longer amount of time when compared to the amount of time non-platelet covered anticancer drugs stayed in the body. The results of this experiment showed that platelet covered anticancer drugs stayed in the body longer than the same anticancer drugs surrounded by a nano-gel system. In this experiment, the dependent variable was the amount of time the anticancer drugs stayed in the body of a mouse.

The ongoing nanoparticle systems have provided a semi-solid foundation in mitigating tumours but further arenas are being explored in cancer therapeutics so as to enhance the drug delivery process. The researchers have suggested and made use of nanoparticles in the size range of 1 -100 nm. Nanoparticles are known to elicit a

Nano-Bio Interactions: Create novel platforms for the direct investigation of the nanoparticle-cell interactions, which are very important both to understand nanotoxicity and develop new Nanotoxicology assessment tools.

This technology gives the new directions in research, patenting, education and also in technology transfer related to different field. Out of different field one area is ‘naomedicine drug delivery’ in which the development is progressing more rapidly. This sector belongs to the application of nanotechnology to drug delivery. In this sector hundreds of products related to nanotechnology based are available in the market and more products will be come in next decade

All statistical analysis in this proposal will be done in collaboration with the Ohio State University Comprehensive Cancer Center Biostatistics Shared Resource. All cell based studies in Aim 1 will be performed in triplicate. All results will be summarized using mean ± SEM, range and median for each continuous measurement and as proportions with confidence intervals for each dichotomous measurement. For in vivo studies proposed in Aim 2, 5 animals per arm will be utilized to validate in vivo impact of nanoparticle delivered drugs. Immunofluorescence analysis of resulting tumors will be compared for differences between the groups using ANOVA generating two-sided p-values, adjusting for the molecular subtype and accounting for repeated measures over time. For the 4 group comparison,

Reported incidences of toxicity due to aluminium based vaccines have always been a concern (Clements, 1996; Clements and Griffiths, 2002; Edleman, 1997). Therefore, there has always been a constant effort to search for alternative adjuvants. Polymeric micro and nanoparticles can act as a delivery vehicle and along with their adjuvanting capabilities may enhance the efficacy of the vaccine (Gregory et al., 2013; Koping-Hoggard et al., 2005; Panyam and Labhasetwar, 2003). Biodegradable polymeric nanoparticles have been studied as potential adjuvants by many researchers but no considerable success has been achieved in this direction. Moreover, in none of these studies, immunised test animals were exposed to the actual disease causing agent and efficacy of the formulations was demonstrated only by the presence of anti-tetanus antibodies by ELISA (Johansen et al., 2000; Katare and Panda, 2006; Raghuvanshi et al., 2001). Absolute estimation of vaccine efficacy should also be made by exposing the vaccinated individual to the actual disease causing agent. Furthremore, for a vaccine to be used in pre-clinical or clinical studies, potency testing of vaccine should be undertaken as per WHO and/or pharmocopoeial guidelines for ensuring its efficacy and acceptability (European Pharmacopoeia, 2008; Indian Pharmacopoeia, 2010; World Health Organisation, 1990). In our study, the efficacy of the test formulations was evaluated by ELISA as well as challenge method and synergistic effect of

The application of nanotechnology for cancer therapy has received considerable attention in recent years. Cancer nanotechnology (an interdisciplinary area of research in science, engineering and medicine) is an upcoming field with extensive applications. It provides a unique approach and comprehensive technology against cancer through early diagnosis, prediction, prevention, personalized therapy and medicine. Target-specific drug therapy and methods for early diagnosis of pathologies are the priority research areas in which nanotechnology would play a vital part. This review focuses on the approaches of cancer nanotechnology in the advancement of cancer therapy.

Conventional drug delivery systems (DDSs) are often accompanied by systemic side effects that mainly are attributed to their nonspecific bio-distribution and uncontrollable drug release characteristics. To overcome these limitations, advanced controlled DDSs have been developed to achieve the release of payloads at the target sites in a spatial controlled manner.

The enormous potential in the biomedical capabilities of nano robots and the imprecision and side effects of medical treatments today make nano robots very desirable.