1) Using Punnett Squares, determine which genotypes are possible at each gene locus if you cross Parent A and Parent B (2 pt). Hypomelanism (H/h): DRAGON A Genetic Stripe (G/g) DRAGON A DRAGON B DRAGON B DRAGON A DRAGON A Translucent (T/t): DRAGON B Spikes/Scales (B/b): DRAGON B
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- The accompanying pedigree is for a rare, but relativelymild, hereditary disorder of the skin.a. How is the disorder inherited? State reasons for youranswer.b. Give genotypes for as many individuals in thepedigree as possible. (Invent your own defined allelesymbols.)c. Consider the four unaffected children of parentsIII-4 and III-5. In all four-child progenies from parentsof these genotypes, what proportion is expected tocontain all unaffected children?(picture added)This problem examines possible biochemical explanations for variations of Mendel’s 9:3:3:1 ratio. Exceptwhere indicated, compounds 1, 2, 3, and 4 have different colors, as do mixtures of these compounds. Aand B are enzymes that catalyze the indicated steps ofthe pathway. Alleles A and B specify functional enzymes A and B, respectively; these are completelydominant to alleles a and b, which do not specify anyof the corresponding enzyme. If functional enzyme ispresent, assume that the compound to the left of thearrow is converted completely to the compound to theright of the arrow. For each pathway, what phenotypicratios would you expect among the progeny of a dihybrid cross of the form Aa Bb × Aa Bb?a. Independent pathwaysCompound 4Compound 2Compound 3Compound 1Enz AEnz Bb. Redundant pathwaysCompound 1 Compound 2Enz BEnz Ac. Sequential pathwayCompound 1 Compound 2 Compound 3Enz A Enz Bd. Enzymes A and B both needed to catalyze the reaction indicated.Compound 1 Compound 2A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement?
- The Online Mendelian Inheritancein Man (OMIM) databaseis a catalog of human genesand human disorders that are inheritedin a Mendelian manner. Genetic disordersthat arise from major chromosomalaberrations, such as monosomyor trisomy(the loss of a chromosome orthe presence of a superfluous chromosome,respectively), are not included.The OMIM database, updated daily, is aversion of the book Mendelian Inheritancein Man, conceived and edited by Dr. VictorMcKusick of Johns Hopkins University,until he passed in 2008.The OMIM entries provide links to awealth of information, including DNAand protein sequences, chromosomalmaps, disease descriptions, and relevantscientific publications. In this exercise,you will explore OMIM to answer questionsabout the recessive human diseasesickle-cell anemia and other Mendelianinherited disorders.Exercise I – Sickle-Cell AnemiaIn this chapter, you were introduced torecessive and dominant human traits.You will now discover more about sicklecellanemia as an…. A true-breeding strain of Virginia tobacco has dominantalleles determining leaf morphology (M), leaf color(C), and leaf size (S). A Carolina strain is homozygousfor the recessive alleles of these three genes. Thesegenes are found on the same chromosome as follows:M C S6 m.u. 17 m.u.An F1 hybrid between the two strains is now backcrossedto the Carolina strain. Assuming no interference:a. What proportion of the backcross progeny willresemble the Virginia strain for all three traits?b. What proportion of the backcross progeny willresemble the Carolina strain for all three traits?c. What proportion of the backcross progeny will havethe leaf morphology and leaf size of the Virginiastrain but the leaf color of the Carolina strain?d. What proportion of the backcross progeny will havethe leaf morphology and leaf color of the Virginiastrain but the leaf size of the Carolina strain?I'm having trouble with my genetics study guide, and am stuck on this question. If someone could explain it with the work it would help me so much. Thank you! In humans, the inheritance of the ABO blood group system exhibits both complete dominance (alleles IA and IB are dominant to allele i) and codominance (alleles IA and IB). In addition, thalassemia shows incomplete dominance; heterozygotes (Tt) exhibit a mild form of the disease (thalassemia minor) and homozygotes (tt) have a more severe form (thalassemia major). A man has blood type A and his mother has blood type O. His wife has blood type AB. Both members of the couple have thalassemia minor. What is the probability that they will have a child with: a. thalassemia minor and blood type A? b. no anemia and blood type AB? c. thalassemia major and blood type B?
- Punnet square problems A=Codominant; B=Codominant; O=Recessive Mary is homozygous for type A blood. Steve is homozygous for type O blood. If they have children, what are the possible phenotypes and genotypes of their children, and what is the probability of each? Mary and Steve have a son, Brad. Brad’s wife, Samantha is heterozygous for type B blood. If they have children, what are the possible phenotypes and genotypes of their children, and what is the probability of each? Stella loves roses and decides to cross her red rose with her white rose. All of the resulting offspring of this cross are pink roses. What can you say about the red and white alleles as a result of this cross? Stella decides to cross two of the pink roses. What are the possible genotypes and phenotypes of the offspring and the probabilities of each? DNA replication, Transcription and Translation problems It is S phase of the cell cycle, and time to replicate the cell’s DNA. Using the following strand of DNA…F1 hybrids between two species of cotton, Gossypium barbadenseand Gossypium hirsutum, are very vigorous plants. However, F1crosses produce many seeds that do not germinate and a high percentageof very weak F2 offspring. Suggest two reasons for theseobservations.The accompanying pedigree shows a very unusual inheritance pattern that actually did exist. All progeny areshown, but the fathers in each mating have been omittedto draw attention to the remarkable pattern.a. Concisely state exactly what is unusual about thispedigree.b. Can the pattern be explained by Mendelianinheritance?
- Labrador retrievers may be black, brown, or golden in color (seethe chapter opening photograph on p. 53). Although each colormay breed true, many different outcomes occur if numerous littersare examined from a variety of matings, where the parentsare not necessarily true-breeding. The following results showsome of the possibilities. Propose a mode of inheritance that isconsistent with these data, and indicate the corresponding genotypesof the parents in each mating. Indicate as well the genotypesof dogs that breed true for each color.(a) black * brown ¡ all black(b) black * brown ¡ 1/2 black1/2 brown(c) black * brown ¡ 3/4 black1/4 golden(d) black * golden ¡ all black(e) black * golden ¡ 4/8 golden3/8 black1/8 brown(f) black * golden ¡ 2/4 golden1/4 black1/4 brown(g) brown * brown ¡ 3/4 brown1/4 golden(h) black * black ¡ 9/16 black4/16 golden3/16 brownFor Mendelian inheritance, the nuclear genotype (i.e., the allelesfound on chromosomes in the cell nucleus) directly influences anoffspring’s traits. In contrast, for non-Mendelian inheritance patterns, the offspring’s phenotype cannot be reliably predicted solelyfrom its genotype. For the following traits, what do you need toknow to predict the phenotypic outcome?A. Dwarfism due to a mutant Igf2 alleleB. Snail coiling directionC. Leber hereditary optic neuropathyHi, I'm having trouble with my study guide for my upcoming genetics exam. If someone could please help with work shown and an explanation it would help so much! Thank you!! 2a. The pedigree below represents inheritance of rare condition. What pattern of inheritance is most consistent with the data? Assign alleles to all individuals to support your answer. If an allele is unknown, assign it a ? symbol. NOTE: Individuals whose phenotype or genotype cannot be determined are assumed to be unaffected and homozygous, unless otherwise indicated. 2b. In addition to the alleles you’ve indicated, describe 2 overall features of the pedigree that make it consistent with your chosen form of inheritance. 2c. Based on your mode of inheritance, what is the probability that the child of couple IV-4 x IV-5 will be affected? Show your work. attached is the pedigree