1. Answer all parts of this question. Ci epichlorohydrin propanolol (a) Provide a two-step retrosynthetic analysis of the beta blocker propranolol from 1-naphthol and epichlorohyrin. In your answer account for all synthons, synthetic equivalents, and label the two retrosynthetic arrows. (b) Draw the two reaction schemes with viable reagents required for the synthesis of propranolol. (c) Give a reaction mechanism for the ring-opening step to give propanolol.

1. Answer all parts of this question. Ci epichlorohydrin propanolol (a) Provide a two-step retrosynthetic analysis of the beta blocker propranolol from 1-naphthol and epichlorohyrin. In your answer account for all synthons, synthetic equivalents, and label the two retrosynthetic arrows. (b) Draw the two reaction schemes with viable reagents required for the synthesis of propranolol. (c) Give a reaction mechanism for the ring-opening step to give propanolol.

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 64AP

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