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- 1a. Provide a paper published in a scientific journal between January 2018 and September 2022 that addresses the role of an example of histone modification in affecting expression of a gene by altering histone acetylation/chromatin state of the DNA encoding that gene.If histones are acetylated on a lysine amino acid (an epigenomic mark), are genes in this region likely to be expressed or not? Briefly, in a sentence or two, explain your answer. (Hint: In your answer explain what the DNA and chromatin structure would look like in regions with the acetylation compared to regions without).A cell is homozygous for a LOF mutation in the histone acetyltransferase (HAT) gene. Which of the following is/are true? a. Chromatin in the cell will be more condensed than usual, decreasing expression of genes that should be expressed. b. This will lead to histones with more positive charges on their tails, increasing the interaction between histones and the DNA backbone. c. This will lead to a decrease in DNA methylation and therefore cause an increase in gene expression. d. Chromatin in the cell will be less condensed than usual, increasing expression of genes that should not be expressed.
- What are histone proteins, and how are their DNA binding properties regulated. Indicate if there are any modification(s) that comes on and off that regulates how tightly or loosely the Histone proteins are bound to DNA.Give typing answer with explanation and conclusion Which of the following regions of DNA would you expect to be transcribed. Select all the apply. Marks removed for incorrect selection(s) O a. Enhancer O b. 3' UTR O c. 5' UTR O d. PromoterDavid Seligson and his colleagues examined levels of histone proteinmodification in prostate tumors and their association with clinicaloutcomes (D. B. Seligson et al. 2005. Nature 435:1262–1266). Theyused antibodies to stain for acetylation at three different sites and formethylation at two different sites on histone proteins. They found that the degree of histone acetylation and methylation helped predict whetherprostate cancer would return within 10 years in the patients who had aprostate tumor removed. Explain how acetylation and methylation mightbe associated with tumor recurrence in prostate cancer.
- Which is the expected outcome following the deacetylation of histones? a) Coiling of chromatin, preventing it from being accessed by transcriptional machinery b) Coiling of chromatin, allowing it to be accessed by transcriptional machinery c) Uncoiling of chromatin, preventing it from being accessed by transcriptional machinery d) Uncoiling of chromatin, allowing it to be accessed by transcriptional machineryWhich of these is NOT true of nucleosomes? A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors. B. The position of nucleosomes is fixed on the genome and can not be changed. C. The position and post-translational modifications of histones can be inherited through mitosis. D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.Can you please help with 1a,1b, and 1c please 1a. Find a paper published in a scientific journal between January 2018 and September 2022 that addresses the role of an example of histone modification in affecting expression of a gene by altering histone acetylation/chromatin state of the DNA encoding that gene. What organism and/or cell type did the authors do their study in? 1b. Which histone(s) were affected by the acetylation and/or deacetylation? What gene did they show had altered expression levels in response to the change in histone acetylation? 1c. what effect did the histone modification they studied have on that gene's level of expression - was expression of the gene they examined increased or decreased?
- The retinoblastoma tumor suppressor gene Rb (RB1) codes forthe retinoblastoma protein (pRB). pRB prevents the progression of the cell cycle through G1 if DNA has been damaged. Itdoes so in part because it binds a transcription-activatingdimer referred to as E2F-DP. The pRB-E2F/DP complex recruits a histone deacetylase to chromatin. Explain.Cell (A) contains 3.1 billion (3.1 x 109) base pairs of DNA. Each nucleosome has about 200 bp of DNAwrapped around the histone core.a. What is the maximum number of nucleosomes that can be present in the cell?b. What is the maximum number of H2A histone protein molecules that can be present in the cell?Heterochromatin consists of a) region of euchromatin devoid of histones. b) an AT-rich region occurs every 200 base pairs. c) decondensed, transcriptionally active chromatin. d) highly condensed, transcriptionally inactive chromatin