1. Proteoglycans, such as heparan sulfate are defined as having sulfated glycosaminoglycans that are covalently joined to membrane proteins or secreted proteins. a. Which weak intermolecular force of attraction allows the proteoglycans to interact with extracellular proteins, such as antithrombin (AT) in the diagram below? b. Provide the full name of the moiety on the proteoglycan that interacts with the protein. c. Provide the name of one of the amino acid residues within the protein (AT) that is likely to interact with the proteoglycan Conformational activation Factor Xa AT Heparan sulfate LNS domain A conformational change induced in the protein antithrombin (AT) on binding a specific pentasaccharide NS domain allows its interaction with blood clotting factor Xa, preventing clotting.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Question

HANDWRITTEN ONLY, solve all parts of this ques...

1. Proteoglycans, such as heparan sulfate are defined as having
sulfated glycosaminoglycans that are covalently joined to membrane
proteins or secreted proteins.
a. Which weak intermolecular force of attraction allows the
proteoglycans to interact with extracellular proteins, such as
antithrombin (AT) in the diagram below?
b. Provide the full name of the moiety on the proteoglycan that
interacts with the protein.
c. Provide the name of one of the amino acid residues within the
protein (AT) that is likely to interact with the proteoglycan
Conformational activation
Factor Xa
AT Heparan
sulfate
- NS domain
A conformational change induced in the protein
antithrombin (AT) on binding a specific
pentasaccharide NS domain allows its interaction
with blood clotting factor Xa, preventing clotting.
Transcribed Image Text:1. Proteoglycans, such as heparan sulfate are defined as having sulfated glycosaminoglycans that are covalently joined to membrane proteins or secreted proteins. a. Which weak intermolecular force of attraction allows the proteoglycans to interact with extracellular proteins, such as antithrombin (AT) in the diagram below? b. Provide the full name of the moiety on the proteoglycan that interacts with the protein. c. Provide the name of one of the amino acid residues within the protein (AT) that is likely to interact with the proteoglycan Conformational activation Factor Xa AT Heparan sulfate - NS domain A conformational change induced in the protein antithrombin (AT) on binding a specific pentasaccharide NS domain allows its interaction with blood clotting factor Xa, preventing clotting.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Intelligence
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education