1. You have a glucose molecule that is radiolabeled at carbon 5.a). Indicate which carbon(s) in pyruvate would be radiolabeled:b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on theCH,OHHH.OH HноH3C--cooонfirst isocitrate produced.ÇoOCH2HÇ-CoHO-CHc). Indicate the labeling pattern and distribution in oxaloacetate at the end of thisturn of the TCA cycle.:čooCooCH2d). What turn of the TCA cycle would label start to be lost as CO; (1 turn has been completed) ?e). Which carbon in pyruvate would have been labeled to give you the labeling pattern in part c, if that pyruvatewent through PDH and the TCA cycle, instead of pyruvate carboxylase.H3C-cof). How is the label in part c physically distributed on actual oxaloacetate molecules?

In glycolysis glucose converted to pyruvate via glycolysis.

1. You have a glucose molecule that is radiolabeled at carbon 5. a). Indicate which carbon(s) in pyruvate would be radiolabeled: b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the CH,OH H H. OH H но H3C- -coo он first isocitrate produced. CH2 HC -coo HO-CH čoo c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this turn of the TCA cycle.: Coo CH2