2. Aspirin is absorbed into the blood through the cells lining the stomach and the small intestine. Absorption requires passage through the plasma membrane, the rate of which is determined by the polarity of the molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly a. The pH inside the stomach is around 2.0 and the pH of the contents of the small intestine is about 6.0. Which of the following statements is correct: i. The small intestine has 3 times lower [H] than the stomach. ii. The small intestine has 4 times lower [H ] than the stomach iii. The small intestine has 3,000 times lower [H] than the stomach iv. The small intestine has 10,000 times lower [H] than the stomach. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Small Intestine (pH= 6.0): Stomach (pH 2.0) Overall Charge: Overall Charge:

Question
2. Aspirin is absorbed into the blood through the cells lining the stomach and the small intestine. Absorption
requires passage through the plasma membrane, the rate of which is determined by the polarity of the molecule:
charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic
ones pass rapidly
a. The pH inside the stomach is around 2.0 and the pH of the contents of the small intestine is about 6.0.
Which of the following statements is correct:
i. The small intestine has 3 times lower [H] than the stomach.
ii. The small intestine has 4 times lower [H ] than the stomach
iii. The small intestine has 3,000 times lower [H] than the stomach
iv. The small intestine has 10,000 times lower [H] than the stomach.
b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it
is in the stomach or in the small intestine:
Small Intestine (pH= 6.0):
Stomach (pH 2.0)
Overall Charge:
Overall Charge:

Image Transcription

2. Aspirin is absorbed into the blood through the cells lining the stomach and the small intestine. Absorption requires passage through the plasma membrane, the rate of which is determined by the polarity of the molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly a. The pH inside the stomach is around 2.0 and the pH of the contents of the small intestine is about 6.0. Which of the following statements is correct: i. The small intestine has 3 times lower [H] than the stomach. ii. The small intestine has 4 times lower [H ] than the stomach iii. The small intestine has 3,000 times lower [H] than the stomach iv. The small intestine has 10,000 times lower [H] than the stomach. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Small Intestine (pH= 6.0): Stomach (pH 2.0) Overall Charge: Overall Charge:

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