2. Aspirin is absorbed into the blood through the cells lining the stomach and the small intestine. Absorptionrequires passage through the plasma membrane, the rate of which is determined by the polarity of the molecule:charged and extremely polar molecules pass slowly, whereas neutral and hydrophobicones pass rapidlya. The pH inside the stomach is around 2.0 and the pH of the contents of the small intestine is about 6.0.Which of the following statements is correct:i. The small intestine has 3 times lower [H] than the stomach.ii. The small intestine has 4 times lower [H ] than the stomachiii. The small intestine has 3,000 times lower [H] than the stomachiv. The small intestine has 10,000 times lower [H] than the stomach.b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when itis in the stomach or in the small intestine:Small Intestine (pH= 6.0):Stomach (pH 2.0)Overall Charge:Overall Charge:

Question
Asked Sep 16, 2019
2. Aspirin is absorbed into the blood through the cells lining the stomach and the small intestine. Absorption
requires passage through the plasma membrane, the rate of which is determined by the polarity of the molecule:
charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic
ones pass rapidly
a. The pH inside the stomach is around 2.0 and the pH of the contents of the small intestine is about 6.0.
Which of the following statements is correct:
i. The small intestine has 3 times lower [H] than the stomach.
ii. The small intestine has 4 times lower [H ] than the stomach
iii. The small intestine has 3,000 times lower [H] than the stomach
iv. The small intestine has 10,000 times lower [H] than the stomach.
b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it
is in the stomach or in the small intestine:
Small Intestine (pH= 6.0):
Stomach (pH 2.0)
Overall Charge:
Overall Charge:
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2. Aspirin is absorbed into the blood through the cells lining the stomach and the small intestine. Absorption requires passage through the plasma membrane, the rate of which is determined by the polarity of the molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly a. The pH inside the stomach is around 2.0 and the pH of the contents of the small intestine is about 6.0. Which of the following statements is correct: i. The small intestine has 3 times lower [H] than the stomach. ii. The small intestine has 4 times lower [H ] than the stomach iii. The small intestine has 3,000 times lower [H] than the stomach iv. The small intestine has 10,000 times lower [H] than the stomach. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Small Intestine (pH= 6.0): Stomach (pH 2.0) Overall Charge: Overall Charge:

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Expert Answer

Step 1

Part a)

The pH inside the stomach is around 2.0 and pH of the small intestine is about 6.0. We have to compare the H+ ion concentration in the stomach and in intestine.

Step 2

Calculate the H+ ion concentration in the stomach and in intestine.

pH log H
or
H10
In stomach, pH2
[H] 102
In intestines, pH = 6
[H106
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pH log H or H10 In stomach, pH2 [H] 102 In intestines, pH = 6 [H106

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Step 3

Compare the H+ ion concentration in the ...

106
102 10000
[H antestine10
1
stomach
[H Jstomach
: [H
intestine
10000
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106 102 10000 [H antestine10 1 stomach [H Jstomach : [H intestine 10000

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