2. coined by Francis Crick? Does SARS-CoV-2 conform to the central dogma of molecular biology that was 3. Explain the flow of genetic information in HIV. Retroviruses, like the HIV, contain an enzyme called reverse transcriptase. 4. COVID-19 vaccines such as Moderna (MRNA-1273) and Pfizer (BNT16262) make use of mRNA that produces SARS-CoV-2 spike protein. Would the effectiveness of these vaccines be affected by the emerging SARS-CoV-2 variants with mutated spike protein?
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- The success of HAART (highly active antiretrovial therapy) against HIV is based on the idea that the probability of having an HIV virion that can simultaneously resist multiple anti-HIV drugs is very low. You were asked to investigate whether the same principle can be applied to another RNA virus, called Virus X. This is what you know about Virus X. (1) For a given antiviral drug, approximately 1 in 1,000 virions may carry a mutation that confers resistance against the said drug. (2) Roughly a total of 1010 virions can be found in an individual infected with Virus X. Assuming that all the drugs work independently of each other (i.e., mutations that allow resistance to one drug have no effect on the resistance to the other drugs), then minimally how many drugs are needed for this treatment regimen to work? Question 4 options: 1) 7 2) 6 3) 5 4) 4 5) 3Bacteria exposed to viruses incorporate sections of the virus’s DNA into the CRISPR array sequences in their genome. This mechanism allows bacteria to fight off the viruses, like an immune response: the information in CRISPR spacers served as “coordinates” for recognizing and cutting up invading DNA sequences. Describe what might happen under the conditions described after a bacteriophage infects a bacterial cell and releases its DNA into the bacterial cell. Explain why: 1. The invading phage DNA is recognized by the Cas proteins but not inserted into the CRISPR array region of the bacterial genome: The bacteria will be unable to elicit an immune response and will succumb to the phase infection 2. The cas genes on the bacterial genome contains a missense mutation that increases its cleavage/cut activityThe bacteria will elicit an immune response that will successfully fight the phage infection4 ______________ studies revealed that some mRNA molecules are formed by splicing pre-mRNA. A.Adenovirus DNA hybridization B.Complementation C.Mutagenesis D.Sequencing 1 分 5 In 1998 Fire, Mellow and coworkers discovered that in C. elgans: A.long double-stranded RNAs can cause sequence-specific gene silencing B.short single-stranded RNAs can cause nonspecific gene silencing C.double-stranded RNAs of any length can cause nonspecific gene silencing D.long single-stranded RNAs can cause sequence-specific gene silencing 1 分 6 RNAi seldomly spreads to: A.the neurons B.the liver C.the brain D.the heart
- How do pseudogenes differ from genes? a. They are not transcribed. b. They contain longer open reading frames (ORFs). c. They do not have introns. d. They use a different genetic code. e. Their protein-coding sequence contains more than one startcodon.1. If you are to compare a virus such as a COVID-19 virus or SARS CoV-2 from a bacterium based on Central Dogma of Molecular Biology, what comparison will you give?1."What protein structural features are involved in the antigenic nature of epitopes? 2.What steps occur in the immune response following the primary infection of a vertebrate by a virus? 3.Assume you know that for a particular non‐enveloped virus, gene A codes for a transcriptional activator, gene B for an origin binding protein, and gene C for a capsid protein. Following a normal infection in an animal, what would most likely generate a neutralizing antibody?"
- 1. Methods of gene therapy 2. Explain Small RNAs and long non coding RNA. 3.what is name of the technique that would help a person who inherited LFS to have a child without the defective allele? 4 .Describe the main technique for amplifying a segment of DNA (like the one you suspect is involved in Lee’s cancer) from a complex mixture of genomic DNA. Remember that the entire human genome sequence is known. (Hint: This is a technique that is commonly used by laboratories that do genetic testing and various other applications of molecular biology.) 5. If Dr. Aikenhed wanted to see if there was mutation within the protein-coding sequence of the gene implicated in this disorder (as opposed to mutations afecting regulatory elements), what technique involving dideoxynucleotides could be used? Briefy describe this technique.1. What impacts might mutations have on the transmission of the virus (COVID-19)? 2. At which stage of viral infection did these mutations most likely occur (COVID-19)?What is the actual biological purpose of the CRISPR/Cas9 system? 9.2. Explain the fundamental difference between CRISPR/Cas9 and in vivo adenovirus-based gene therapy Explain why there is a part of the LacZ gene in pET32a(+) and also how the natural biochemical process wherein it normally functions is used during cloning by molecular biology.
- 5 How the use of the nucleic acid vaccine gives protection against diseases like COVID-19. Please briefly explain .?The new Covid19 vaccine produced by two companies (Pfizer, Moderna) uses mRNA coding for part of the spike protein of the virus. The virus uses the spike protein to invade human cells where it replicates. Is it surprising that the mRNA must be stabilized with chemicals that need ultra-cold or frozen storage to protect the mRNA from degradation before it causes human muscle cells to make the spike protein? Some Covid 19 vaccines in development use the adenovirus, a common vector used in gene therapies, to inject the mRNa for the spike protein into human muscle cells. Why might vaccines using a virus vector be more likely to need only refrigeration and not deep-cold storage, given what you know about viruses? Some older vaccines used a weakened strain of the pathogenic virus in the injection in the hope that the weakened virus would induce an immune response without causing disease. The virus vectors used in genetic engineering have all the harmful virus genes cut out and replaced with…Bacteria exposed to viruses incorporate sections of the virus’s DNA into the CRISPR array sequences in their genome. This mechanism allows bacteria to fight off the viruses, like an immune response: the information in CRISPR spacers served as “coordinates” for recognizing and cutting up invading DNA sequences. Describe what might happen under the conditions described after a bacteriophage infects a bacterial cell and releases its DNA into the bacterial cell. Explain why: The cas genes on the bacterial genome contains a frameshift deletion mutation that alters the function of the protein The bacteria will be unable to elicit an immune response and will succumb to the phase infection