20. When the ratio of ATP to AMP is low, PFK-1 is a. Activated b. Inhibited at an allosteric site C. Inhibited at its active site d. None of the above
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- 2. Which of the following statements is TRUE about phosphofructokinase-1? Select one: a. It is stimulated by AMP and ADP. b. It is inhibited by AMP and ADP. c. It is stimulated by citrate and ADP. d. It is stimulated by citrate and ATP.The effect of high levels of ADP is to__inv __ cellular respiration. increase the activity of specific enzymes decrease the activity of specific enzymes have no effect on the activity of specific enzymes slow down the pathway4. Hexokinase is kinase that catalyzes the phosphorylation of glucose by ATP to glucose-6-P, which can bind toits active site, blocking the access to ATP. Which of the following statements is/are correct regarding the typeof regulation?a) Phosphorylationb) Dephosphorylation.c) Feedback inhibition.d) Repression Explain each of the following option
- 5. Which of the following statements is/are correct regarding allosteric regulation?a) Allosteric effector controls the activity of an enzyme by irreversible binding.b) Allosteric effector binds to the regulatory sitec) Allosteric activator causes changes in the catalytic site enhancing the substrate binding.d) Allosteric inhibitor causes changes in the catalytic site decreasing the substrate binding. explain each optionThe effectiveness of allosteric effectors in regulating metabolic pathways is based on their ability to— interact with multiple substrate-binding sites on the target enzyme(s). interfere with competitive inhibitors. alter the concentration of the target enzyme(s). denature the target enzyme(s). change the conformation of the target enzyme(s).A drug with which of the following molecular mechanisms of action would be least likely to function as a DHFR inhibitor? Group of answer choices A) Block substrate from binding to the DHFR active site B) Alter folding to increase NADPH cofactor binding C) Increase DHFR degradation
- The active site of chymotrypsin indicates that the following residues are needed: a. Asp and Asp b. His and Cys c. Asp, His and Ser d. His and Zn2+ e. Asn, His and ThrA simple plot of V0 versus [S] is superior to a double-reciprocal plot (1/Vo versus 1/[S]) if you are trying to A. determine Vmax. B. detect allosteric regulation. C. determine the type of inhibition. D. determine the Km.Sketch the arrow pushing mechanism of the hydrolysis of phospho-serine by the emzyme phosphatase. The enzyme has a catalytic diad. Cys (pka 8.2) and glu (pka 4.3)
- When glucose reacts with ATP to form glucose-6-phosphate: a. the synthesis of glucose-6-phosphate is exergonic. b. ADP is at a higher energy level than ATP. c. glucose-6-phosphate is at a higher energy level than glucose. d. because ATP donates a phosphate to glucose, this is not a coupled reaction. e. the reaction is spontaneous.In signal transduction, which of the following is not a target protein? a. proteins that regulate gene activity b. hormones that activate the receptor c. enzymes of pathways d. transport proteins e. enzymes of cell reactionsWhat is the effect of an inhibitor binding an enzyme? The enzyme is degraded. The enzyme is activated. The enzyme is inactivated. The complex is transported out of the cell