Part 1 See Periodic Table O See Hint For the regulation of the purine synthesis pathway shown, what would happen if there were an excess of AMP? Choose one or more: O A Excess AMP would directly lead to decreased GDP levels, accelerating production of all purines in this pathway. O B. Excess AMP would directly lead to decreased ATP, thereby decreasing GMP production. O CExcess AMP would directly decrease guanine nucleotide production. O D.Excess AMP would directly block the production of more adenine nucleotides. Part 2 O See Hint Howdoes this regulatory mechanism keep the balance of adenine versus guanine nucleotides? Choose one or more: O A High levels of any purine inhibit glutamine-PRPP amidotransferase, preferentlally inhibiting one purine synthesis pathway over the other. O B. The triphosphate form of one purine is necessary for synthesis of the other purine. Thus as the level of GTP is reduced, the capacity to produce AMP is reduced (and vice versa). O C High monophosphate forms of one purine inhibit further synthesis of its respective pathway, but not the other purine pathway. O D.The diphosphate forms positively feed back, accelerating purine synthesis.

Part 1 See Periodic Table O See Hint For the regulation of the purine synthesis pathway shown, what would happen if there were an excess of AMP? Choose one or more: O A Excess AMP would directly lead to decreased GDP levels, accelerating production of all purines in this pathway. O B. Excess AMP would directly lead to decreased ATP, thereby decreasing GMP production. O CExcess AMP would directly decrease guanine nucleotide production. O D.Excess AMP would directly block the production of more adenine nucleotides. Part 2 O See Hint Howdoes this regulatory mechanism keep the balance of adenine versus guanine nucleotides? Choose one or more: O A High levels of any purine inhibit glutamine-PRPP amidotransferase, preferentlally inhibiting one purine synthesis pathway over the other. O B. The triphosphate form of one purine is necessary for synthesis of the other purine. Thus as the level of GTP is reduced, the capacity to produce AMP is reduced (and vice versa). O C High monophosphate forms of one purine inhibit further synthesis of its respective pathway, but not the other purine pathway. O D.The diphosphate forms positively feed back, accelerating purine synthesis.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter26: Synthesis And Degradation Of Nucleotides

Section: Chapter Questions

Problem 6P: Allosteric Regulation of Ribonucleotide Reductase by ATP and Deoxynucleotides Describe the...

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