3.Tris(hydroxymethyl)aminomethane [(HOCH2)3CNH2-Tris or THAM] is a weak base frequently used to prepare buffers in biochemistry. Its Kb is 1.2 x 10^-6 and pKb is 5.92. The corresponding pKa is 8.08, which is near the pH of the physiological buffers, and so it exhibits good buffering capacity at physiological pH. What weight of THAM must be taken with 100 mL of 0.50 M HCl to prepare 1L of a pH 7.90 buffer?

3.Tris(hydroxymethyl)aminomethane [(HOCH2)3CNH2-Tris or THAM] is a weak base frequently used to prepare buffers in biochemistry. Its Kb is 1.2 x 10^-6 and pKb is 5.92. The corresponding pKa is 8.08, which is near the pH of the physiological buffers, and so it exhibits good buffering capacity at physiological pH. What weight of THAM must be taken with 100 mL of 0.50 M HCl to prepare 1L of a pH 7.90 buffer?

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter20: Acidity And Pka Of Phenols

Section: Chapter Questions

Problem 3CTQ

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