6. As the pKa of a proton donor (acid) increases (becomes numerically larger), the nucleophilicity of its conjugate base:

Organic Chemistry: A Guided Inquiry
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Author:Andrei Straumanis
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Chapter27: Amines
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6. As the pKa of a proton donor (acid) increases (becomes numerically larger), the nucleophilicity
of its conjugate base:
Transcribed Image Text:6. As the pKa of a proton donor (acid) increases (becomes numerically larger), the nucleophilicity of its conjugate base:
Expert Solution
Step 1

1) High pKa value means weak acid, 

low pKa value means strong acid.

2)   Strong acid have weak conjugate base

and Weak acid have strong conjugate base.

And a conjugate base is always a stronger nucleophile.

 

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