7. Consider the reaction below n cns Ph си, HI ph H3C E, product A. The trans product shown is the only observed product of the reaction. Provide a mechanistic explanation as to why none of the cis product is formed. (You do not need to show transition states) ри H- Br си, Dr Br си CH3 EtONa ethanol ני Ez product B. Predict the major product if the conditions of the reaction are changed to potassium tert-butoxide in tert-butyl alcohol solvent.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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