A 42-year-old woman comes to the physician for a follow-up examination after two separate Pap smears have shown dysplastic epithelial cells. Results of a molecular diagnostic test show DNA that encodes high-risk versions of the human papillomavirus E6 and E7 proteins. The viral E6 protein binds to the cellular p53 tumor suppressor gene, causing it to be degraded. Which of the following best describes the mechanism by which the E6 protein causes cervical cancer? (A) Arrests the cell cycle (B) Enhances tissue invasion and metastasis (C) Inhibits telomerase expression (D) Prevents apoptosis (E) Sustains angiogenesis

A 42-year-old woman comes to the physician for a follow-up examination after two separate Pap smears have shown dysplastic epithelial cells. Results of a molecular diagnostic test show DNA that encodes high-risk versions of the human papillomavirus E6 and E7 proteins. The viral E6 protein binds to the cellular p53 tumor suppressor gene, causing it to be degraded. Which of the following best describes the mechanism by which the E6 protein causes cervical cancer? (A) Arrests the cell cycle (B) Enhances tissue invasion and metastasis (C) Inhibits telomerase expression (D) Prevents apoptosis (E) Sustains angiogenesis

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 15QP: Which of the following mutations will result in cancer? a. homozygous recessive mutation in a...

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Human Papillomaviruses has of many strains. Some of them cause warts while others can cause cancer. The question is why some strains cause cancer and others cause relatively harmless warts. Please mention the status of the viral genome (or parts of it), such as integrated or free, and the action of the viral oncogenes in terms of promoting cell division (when it would normally be controlled). And what proteins do the products of the viral oncogenes target? And also what is their normal function?
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The product of the human papillomavirous oncogene E7promotes cancer by emhancing expression of telomere inhibiting DNA damage repair pathways binding to Rb protein and preventing itd function ubiquitinating the tumor suppressor p53
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Which of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressed
Cancer-promoting mutations are likely to have different effects on the activity of proteins encoded byproto-oncogenes than they do on proteins encodedby tumor-suppressor genes. Explain.
Explain in general what is meant by a proto-oncogene and how they are involved in the formation of a tumor