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Which of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressed

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 15QP
Textbook Problem
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Which of the following mutations will result in cancer?

  1. a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein
  2. b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed
  3. c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional
  4. d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressed

Summary Introduction

Introduction: Cancer is caused due to a mutation in the genome of the cells. The mutation can be of different types namely single nucleotide, substitutions, and variations in gene copy number, insertions, deletions, and chromosome rearrangements. These variations cause an alteration in the gene sequence, resulting in the cells to inhibit the property of contact inhibition.

Explanation of Solution

Reason for correct answer:

The products of the tumor-suppressing gene are responsible for preventing the cell to grow unchecked and abnormally. The removal or inactivation of tumor suppressor genes causes uncontrolled division in cells. Cancer development through a tumor–suppressor gene requires both the alleles to be mutated.

Proto-oncogenes are the genes that are normally involved in the cell cycle of the cells as these genes code for the proteins that help in regulating the cell growth and cell division. Due to a dominant mutation in these genes, the product is overexpressed. This type of mutation is a dominant mutation and the presence of even a single gene will lead to cancer development.

Option a. is given as “homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein”

Option d. is given as “dominant mutation in a proto-oncogene in which the normal protein product is overexpressed”

Mutation in the tumor suppressor gene causes an alteration in the protein structure, making it nonfunctional. These proteins are responsible for checking the growth of cells...

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