(A) (B) hs-Fz/+ hs-Fz/+ +/+ Dsh A/+ Figure Q15-5 Pattern of hair growth on wing cells in genetically different Drosophila (Problem 15-17). (From C.G. Winter et al., Cell 105:81-91, 2001. With permission from Elsevier.) 3
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The Wnt planar polarity signaling pathway nor-
mally ensures that each wing cell in Drosophila has a sin-
gle hair. Overexpression of the Frizzled gene from a heat-
shock promoter (hs-Fz) causes multiple hairs to grow from
many cells (Figure Q15–5A). This
if hs-Fz is combined with a heterozygous deletion (DshΔ)
of the Dishevelled gene (Figure Q15–5B). Do these results
allow you to order the action of Frizzled and Dishevelled
in the signaling pathway? If so, what is the order? Explain
your reasoning
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