Help me please The sustained Merkel receptor complex touch response depends on activation of the ion channelPiezo2 and a complex interplay between the Merkel cells and the nerve fibers that innervate them.A) Describe how the sustained response is generated. B) Is there a way you could convert theresponse of complex from sustained to transient without altering Piezo2 by addition of an ionchannel to one of the cell types? Explain what type of channel, what cell type would express it andwhy it would work.

Hello. Since your question has multiple parts, we will solve first question for you. If you want…

Answered: A) Describe how the sustained response…

Science

Biology

A) Describe how the sustained response is generated. E

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section4.5: Intercellular Communication And Signal Transduction

Problem 3CYU: Outline the three general means by which binding of a water soluble extracellular chemical messenger...

See similar textbooks

Related questions

Q: Describe the local and systemic effects of inflammation.

A: Inflammation generally refers to the response of the tissue during an injury or damage. It is…

Q: Describe when inflammation is good and when it is bad

A: Animal physiology is the systematic study of the supporting features, roles, and processes of…

Q: Define the term inflammation?

A: The branch of science which deals with the different components of immune system is called…

Q: Describe an example of an ‘overreaction’ of the inflammatory response, including the specific…

A: The immune system of a body is broadly classified into innate and adaptive type. Innate immunity is…

Q: Describe two methods used to reduce the severity of atissue rejection reaction.

A: Tissue transplantation is a method adopted to repair damaged tissue by extracting the tissue cell…

Q: Explain what causes an allergic reaction.

A: An allergic reaction is a response generated by the immune system of the body. This causes various…

Q: Describe what will enhance utilization of drugs that are administered orally, topically, and…

A: Any substance on consumption that causes changes in the physiology and psychology of the person is…

Q: Describe the initial response system that is found in the primary responders to foreign matter.

A: The immune system is a well-developed system of higher animals that provides protection or defence…

Q: Define agglutinogen?

A: We know that Agglutinogen can cause the agglutination of cells that contain the antigen or particles…

Q: What are the cardinal signs of inflammation and what causes them?

A: Inflammation is a response which is triggered by damage to living tissues. Inflammatory reponse is a…

Q: Explain The local inflammatory events occurring in response to a wound?

A: Answer- Inflammation is the process which is a part of immune response at the site of infection to…

Q: All of the following are signs of inflammation except

A: Inflammation is a defense mechanism used by your body's white blood cells and the substances they…

Q: Define the term inflammation and explain their signs and symptoms.

A: BASIC INFORMATION DISEASE It is basically the illness of the body. This affects our bodily…

Q: Explain the inflammatory response

A: Answer: Introduction: Both infectious and non-infectious carriers and cell injury activate…

Q: Describe the processing and presentation of an intracellular antigen.

A: Antigen processing and presentation is an immunological process through which the antigen-presenting…

Q: Explain the differences between acute and chronic inflammation.

A: Inflammation is a body response to infections to protect tissues from injury or disease. The…

Q: Explain Excessive Inflammatory Responses?

A: Response evoked by the injury is termed inflammation. The inflammatory response is a defense…

Q: When immediate allergic response can occur ?

A: The immune system is one of the most important parts of our body. This system detects any foreign…

Q: Explain why allergic responses tend to recur.

A: Allergic reactions, also known as hypersensitive reactions. It occurs when our immune system starts…

Q: Differentiate local from systemic signs of malignantneoplasms and include an example of each.

A: Cancer refers to the condition characterized by abnormal growth of cells that have the potential to…

Q: Explain Cell Death Types along with associated diseases

A: When any abnormalities are arises within the cell then the cell shows different process that…

Q: Explain how cor pulmonale may develop.

A: Cor pulmonale is a condition that occurs due to pulmonary hypertension and it mainly occurs in the…

Q: Define emulsify

A: Emulsification has wide variety of uses like in pharmaceutical industries, chemical synthesis,…

Q: List the cardinal signs of inflammation and state thecause of each.

A: Inflammation can be defined as the process in which white blood cells attack pathogens invading the…

Q: Describe the clonal deletion.

A: The immune system is a sophisticated biological system that can recognize and accept self-cells…

Q: Define agglutinin

A: Immunoglobulins (Ig) are also designated as antibodies (Ag) and helps in killing the pathogenic…

Q: Explain agglutinogen?

A: Agglutinogen is a type of protein on the surfaces of RBC. They react with antibodies (agglutinins).…

Q: Define an autoimmune disease, and explain howthe causative mechanism differs from a normaldefense.

A: Autoimmunity is defined as the inability of the body to distinguish between self and non-self. This…

Q: b. Explain the pathogenesis of Hamid's condition. What is the most common cause of his condition?…

A: On the basis of history probable diagnosis is Diabetic foot with ulceration. Ans.B) Pathogenesis of…

Q: Define the types of the body response against microbes briefly ?

A: Our body has different mechanisms to fight against the disease-causing harmful microbes. Infection…

Q: Fever can indicate that

A: Innate immunity is present since birth. It is formed by four barriers. A) Physical barrier - It…

Q: Describe three types of adverse reactions.

A: 'A noxious and unanticipated adverse reaction to a medicine that occurs at levels routinely employed…

Q: Define inflammation, and discuss the basic steps involved, including the formation of exudate and…

A: Inflammation is a biological response of the immune system that can be triggered by a variety of…

Q: Define a fever, and describe how it occurs.

A: The normal body temperature of human body is 37°C. Some individuals will have a temperature lower…

Q: Describe the phagocytic function of mesangial cells.

A: Mesangial cells are specialty cells in the renal components of the glomerulus mesangium. They…

Q: Explain the effects of chronic inflammation.

A: *Chronic inflammation is a provocative condition that keeps going for a long period and includes…

Q: Explain the causes and effects of immunodeficiency

A: Immunodeficiency diseases are caused by a defect in one or more components of innate or adaptive…

Q: Give the clinical significance of bleeding time

A: KEY WORDS :- Bleeding time - It is the time till bleeding or blood flows till its stop.

Q: What signs and symptoms are associated with inflammation?

A: There are some factors such as: Pathogens, Damaged cells, Irritants These are harmful stimuli and…

Q: List the local signs and symptoms of inflammation.

A: Inflammation is the process when the body fight against the body from causing injury, infection and…

Q: Define the term: antigen

A: An immune response is a reaction that occurs within the body of an organism for the purpose of…

Q: Explain the relationship between inflammation andinfection.

A: Infection occurs when any infectious agent like bacteria, virus enters into the body and damage the…

Q: Define the term Cor pulmonale?

A: Biology terms are fundamental concepts and terms used in biology, which is the study of life and…

Question

Help me please

The sustained Merkel receptor complex touch response depends on activation of the ion channel
Piezo2 and a complex interplay between the Merkel cells and the nerve fibers that innervate them.
A) Describe how the sustained response is generated. B) Is there a way you could convert the
response of complex from sustained to transient without altering Piezo2 by addition of an ion
channel to one of the cell types? Explain what type of channel, what cell type would express it and
why it would work.

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

Clostridium tetani toxin blocks the exocytosis of GABA. A. What anatomical part of a pre-synaptic neuron would be affected by this? B. How would a post-synaptic neuron’s likelihood of experiencing an action potential be affected by this toxin? C. Explain, using at least TWO of the following terms: threshold, depolarization, repolarization, hyperpolarization, summation, IPSP, EPSP, exocytosis
explain in detail ephrin receptor EPHB2 receptor interaction with PDZ ligand. give full step by step explanantion.
A ligand binds two different receptors with a Kd value of 10−7 M for receptor 1 and a Kd value of 10−9 M for receptor 2. For which receptor does the ligand show the greater affinity? Calculate the fraction of receptors that have a bound ligand ([RL]/RT) in the case of receptor 1 and receptor 2 if the con- centration of free ligand is 10−8 M.
Briefly explain the difference between a receptor antagonist and a receptor inverse agonist. Describe both the resulting receptor conformation as well as the signal transduction.
An analog of cGMP, 8-Br-cGMP, will permeate cellular membranes, is only slowly degraded by a rod cell’s PDE activity, and is as effective as cGMP in opening the gated channel in the cell’s outer segment. If you suspended rod cells in a buffer containing a relatively high [8-Br-cGMP], then illuminatedthe cells while measuring their membrane potential, what would you observe?
The membrane potential in animal cells, but not in plants, depends largely on resting K+ channels. How do these channels contribute to the resting membrane potential? Why are these channels considered to be nongated channels? How do these channels achieve selectivity for K+ versus Na+, which is smaller than K+?
Name three features common to the activation of cytokine receptors and receptor tyrosine kinases. Name one difference with respect to the enzyme activity of these receptors.
How does the presence of basic amino acids within the S4 helix allow for voltage gating in thesechannels? Explain how cation movement across the membrane triggers these channels to open.
Based on our discussions for different members of the K+ channel family (which include Kv, KCa, HCN/CNG, Kir, and K2P), which of the following can bind to K+ channels, enhancing activation? Ca++/calmodulin Cyclic nucleotides (cAMP, cGMP) PIP2 All of the above
Cascading effect occurs when a signal is receive by the receptor ( " turned on" ) but how do cells turns off a signal?
Pathways involving G proteins provide an opportunityfor an increase in signal strength in the course of signaltransduction, a change referred to as amplification.How might this be beneficial in olfaction?
The tight binding sites required for ion selectivity should slow the progress of ions through a channel, yet ion channels achieve rapid rates of ion transport. How is this paradox resolved?