A method for the determination of the corticosteroid methylprednisolone acetate in solutions obtained from pharmaceutical preparations yielded a mean value of 3.7 mg mL with a standard deviation of 0.3 mg mL. For quality control purposes, the relative uncertainty in the concentration should be no more than 3%. How many samples of each batch should be analyzed to ensure that the relative standard deviation does not exceed 9% at the 95% confidence level? samples

Fundamentals Of Analytical Chemistry
9th Edition
ISBN:9781285640686
Author:Skoog
Publisher:Skoog
Chapter8: Sampling, Standardization, And Calibration
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Problem 8.13QAP
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[References)
A method for the determination of the corticosteroid methylprednisolone acetate in solutions obtained from pharmaceutical preparations yielded a mean
value of 3.7 mg mL with a standard deviation of 0.3 mg mL. For quality control purposes, the relative uncertainty in the concentration should be
no more than 3%. How many samples of each batch should be analyzed to ensure that the relative standard deviation does not exceed 9% at the 95%
confidence level?
samples
Transcribed Image Text:[References) A method for the determination of the corticosteroid methylprednisolone acetate in solutions obtained from pharmaceutical preparations yielded a mean value of 3.7 mg mL with a standard deviation of 0.3 mg mL. For quality control purposes, the relative uncertainty in the concentration should be no more than 3%. How many samples of each batch should be analyzed to ensure that the relative standard deviation does not exceed 9% at the 95% confidence level? samples
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