A rare dominant mutation expressed at birth was studiedin humans. Records showed that six cases were discoveredin 40,000 live births. Family histories revealed that in twocases, the mutation was already present in one of the parents.Calculate the spontaneous mutation rate for this mutation.What are some underlying assumptions that may affect ourconclusions?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
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Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 10QP: If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense...
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A rare dominant mutation expressed at birth was studied
in humans. Records showed that six cases were discovered
in 40,000 live births. Family histories revealed that in two
cases, the mutation was already present in one of the parents.
Calculate the spontaneous mutation rate for this mutation.
What are some underlying assumptions that may affect our
conclusions?

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